Publications by authors named "Caroline A Jefferies"

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PTPN22-CD45 dual phosphatase retrograde feedback enhances TCR signaling and autoimmunity.
Shen Yang, Eugenio Santelli, Carlos G Gonzalez, Wade T Johnson, Irene V Choi, Caroline A Jefferies

Sci Adv· September 2025

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Loss of Tripartite Motif-Containing Protein 21 and UVB-Induced Systemic Inflammation by Regulating DNA-Sensing Pathways.
Gantsetseg Tumurkhuu, Graziela Perri, Richard Moore, Lihong Huo, Arati Naveen Kumar, Caroline A Jefferies

Arthritis Rheumatol· June 2025

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Mx1-ing it up-Mitochondrial relay for interferon-dependent, unconventional IL-1β release in SLE monocytes.
Andrea Dorfleutner, Christian Stehlik, Caroline A Jefferies

Immunity· November 2024

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Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta.
Tania L Gonzalez, Bryn E Willson, Erica T Wang, Kent D Taylor, Allynson Novoa, Caroline A Jefferies

Biol Sex Differ· August 2024

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High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester†.
Tania L Gonzalez, Sahar Wertheimer, Amy E Flowers, Yizhou Wang, Chintda Santiskulvong, Caroline A Jefferies

Biol Reprod· May 2024

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High-throughput mRNA sequencing of human placenta shows sex differences across gestation.
Amy E Flowers, Tania L Gonzalez, Yizhou Wang, Chintda Santiskulvong, Ekaterina L Clark, Caroline A Jefferies

Placenta· May 2024

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α-Ketoglutarate-Dependent KDM6 Histone Demethylases and Interferon-Stimulated Gene Expression in Lupus.
Erica N Montano, Moumita Bose, Lihong Huo, Gantsetseg Tumurkhuu, Gabriela De Los Santos, Caroline A Jefferies

Arthritis Rheumatol· March 2024

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High-throughput mRNA-seq atlas of human placenta shows vast transcriptome remodeling from first to third trimester.
Tania L Gonzalez, Sahar Wertheimer, Amy E Flowers, Yizhou Wang, Chintda Santiskulvong, Caroline A Jefferies

bioRxiv· June 2023

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Evidence of premature lymphocyte aging in people with low anti-spike antibody levels after BNT162b2 vaccination.
Yapei Huang, Juliana E Shin, Alexander M Xu, Changfu Yao, Sandy Joung, Caroline A Jefferies

iScience· October 2022

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Neutrophils Contribute to ER Stress in Lung Epithelial Cells in the Pristane-Induced Diffuse Alveolar Hemorrhage Mouse Model.
Gantsetseg Tumurkhuu, Duygu Ercan Laguna, Richard E Moore, Jorge Contreras, Gabriela De Los Santos, Caroline A Jefferies

Front Immunol· March 2022

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Regulation of cGAS-STING Pathway - Implications for Systemic Lupus Erythematosus.
Audrey M Hagiwara, Richard E Moore, Daniel J Wallace, Mariko Ishimori, Caroline A Jefferies

Rheumatol Immunol Res· September 2021

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High-throughput miRNA sequencing of the human placenta: expression throughout gestation.
Tania L Gonzalez, Laura E Eisman, Nikhil V Joshi, Amy E Flowers, Di Wu, Caroline A Jefferies

Epigenomics· July 2021

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Type 1 Interferon Gene Signature Promotes RBC Alloimmunization in a Lupus Mouse Model.
June Young Lee, Emaan Madany, Najwa El Kadi, Sumaarg Pandya, Kessandra Ng, Caroline A Jefferies

Front Immunol· June 2021

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Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model.
Gantsetseg Tumurkhuu, Shuang Chen, Erica N Montano, Duygu Ercan Laguna, Gabriela De Los Santos, Caroline A Jefferies

Front Immunol· April 2021

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Herpes simplex virus 1 targets IRF7 via ICP0 to limit type I IFN induction.
David Shahnazaryan, Rana Khalil, Claire Wynne, Caroline A Jefferies, Joan Ní Gabhann-Dromgoole

Sci Rep· December 2020

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Regulating IRFs in IFN Driven Disease.
Caroline A Jefferies

Front Immunol· August 2020

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Nucleic Acid Sensors as Therapeutic Targets for Human Disease.
Sarah M McWhirter, Caroline A Jefferies

Immunity· July 2020

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miR-744-5p contributes to ocular inflammation in patients with primary Sjogrens Syndrome.
Qistina Pilson, Siobhan Smith, Caroline A Jefferies, Joan Ní Gabhann-Dromgoole, Conor C Murphy

Sci Rep· May 2020

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Macrophage MMP10 Regulates TLR7-Mediated Tolerance.
Maryam G Rohani, Elizabeth Dimitrova, Andrew Beppu, Ying Wang, Caroline A Jefferies

Front Immunol· October 2019

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Systemic IL-1β production as a consequence of corneal HSV-1 infection-contribution to the development of herpes simplex keratitis.
Joan Ní Gabhann-Dromgoole, Ciaran de Chaumont, David Shahnazaryan, Siobhán Smith, Conor Malone, Caroline A Jefferies

Int J Ophthalmol· September 2019

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TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages.
Yang Li, Sharmy J James, David H Wyllie, Claire Wynne, Agnes Czibula, Caroline A Jefferies

Proc Natl Acad Sci U S A· August 2019

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IL-16/miR-125a axis controls neutrophil recruitment in pristane-induced lung inflammation.
Siobhan Smith, Pei Wen Wu, Jane J Seo, Thilini Fernando, Mengyao Jin, Caroline A Jefferies

JCI Insight· August 2018

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The RNA binding protein La/SS-B promotes RIG-I-mediated type I and type III IFN responses following Sendai viral infection.
Rebecca Mahony, Lindsay Broadbent, Jacen S Maier-Moore, Ultan F Power, Caroline A Jefferies

Sci Rep· November 2017

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Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory actions in the colon.
Joseph B J Ward, Natalia K Lajczak, Orlaith B Kelly, Aoife M O'Dwyer, Ashwini K Giddam, Caroline A Jefferies

Am J Physiol Gastrointest Liver Physiol· June 2017

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MicroRNA-302d targets IRF9 to regulate the IFN-induced gene expression in SLE.
Siobhán Smith, Thilini Fernando, Pei Wen Wu, Jane Seo, Joan Ní Gabhann, Caroline A Jefferies

J Autoimmun· May 2017

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