Publications by authors named "Chan Kit Lam"

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Quassinoids from Eurycoma longifolia Jack roots and their potential inhibitory activity against human benign prostatic hyperplasia cells (BPH-1) and testosterone-induced BPH rat model.
Mathias-Mathew Hipolith, Boon-Keat Khor, Yusuke Hirasawa, Vikneswaran Murugaiyah, Chong-Yew Lee, Kit-Lam Chan

Fitoterapia· April 2023

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Comparing the pharmacokinetics of 13α,21-dihydroeurycomanone and eurycomanone exclusively enriched in Eurycoma longifolia extracts and their spermatogenesis enhancement in andrographolide-induced oligospermia in rats.
Wan-Jie Chung, Kit-Lam Chan, Chong-Yew Lee

J Pharm Pharmacol· March 2021

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Differentially expressed genes on the growth of mouse Leydig cells treated with standardised Eurycoma longifolia extract.
Nor Amira Khurshid Ahmed, Shern Kwok Lim, Ganesh N Pandian, Hiroshi Sugiyama, Chong Yew Lee, Kit Lam Chan

Mol Med Rep· November 2020

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Black sea cucumber (Holothuria atra Jaeger, 1833) rescues Pseudomonas aeruginosa-infected Caenorhabditis elegans via reduction of pathogen virulence factors and enhancement of host immunity.
Wan-Ting Lee, Boon-Khai Tan, Su-Anne Eng, Gan Chee Yuen, Kit Lam Chan

Food Funct· September 2019

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The phytochemical and anti-inflammatory studies of Dillenia suffruticosa leaves.
Saifullah Abubakar, Majed Ahmed Al-Mansoub, Vikneswaran Murugaiyah, Kit-Lam Chan

Phytother Res· March 2019

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Multi-targeting aurones with monoamine oxidase and amyloid-beta inhibitory activities: Structure-activity relationship and translating multi-potency to neuroprotection.
Kok-Fui Liew, Elaine Hui-Chien Lee, Kit-Lam Chan, Chong-Yew Lee

Biomed Pharmacother· February 2019

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Antiadipogenic effects of a standardized quassinoids-enriched fraction and eurycomanone from Eurycoma longifolia.
D Balan, Kit-Lam Chan, D Murugan, Sazaly AbuBakar, Pooi-Fong Wong

Phytother Res· July 2018

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Polar Quassinoids in Standardized Eurycoma longifolia Extract Formulated into a Lipid-Based Solid Dispersion to Improve Rat Sperm Count.
Hai-Qiu Ma, Forough Ebrahimi, Bin-Seng Low, Nurzalina Abdul Karim Khan, Kit-Lam Chan

Phytother Res· December 2017

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Assessment of the Blood-Brain Barrier Permeability of Potential Neuroprotective Aurones in Parallel Artificial Membrane Permeability Assay and Porcine Brain Endothelial Cell Models.
Kok-Fui Liew, Nur Aziah Hanapi, Kit-Lam Chan, Siti R Yusof, Chong-Yew Lee

J Pharm Sci· February 2017

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1HNMR-Based Discriminatory Analysis of Eurycoma longifolia from Different Locations and Establishing a Profile for Primary Metabolites Identification and Quassinoids Quantification.
Forough Ebrahimi, Baharudin Ibrahim, Chin Hoe Teh, Vikneswaran Murugaiyah, Chan Kit Lam

Planta Med· January 2017

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Urinary NMR-based metabolomic analysis of rats possessing variable sperm count following orally administered Eurycoma longifolia extracts of different quassinoid levels.
Forough Ebrahimi, Baharudin Ibrahim, Chin-Hoe Teh, Vikneswaran Murugaiyah, Kit-Lam Chan

J Ethnopharmacol· April 2016

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The in vitro and in vivo anti-cancer activities of a standardized quassinoids composition from Eurycoma longifolia on LNCaP human prostate cancer cells.
Kind Leng Tong, Kit Lam Chan, Sazaly AbuBakar, Bin Seng Low, Hai Qiu Ma

PLoS One· March 2016

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Flavonoids and phenylethanoid glycosides from Lippia nodiflora as promising antihyperuricemic agents and elucidation of their mechanism of action.
Lee-Chuen Cheng, Vikneswaran Murugaiyah, Kit-Lam Chan

J Ethnopharmacol· December 2015

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Decreased expression of alpha-2-HS glycoprotein in the sera of rats treated with Eurycoma longifolia extract.
Yeng Chen, Wai-Mei Phang, Alan K-W Mu, Choon-Keat Chan, Bin-Seng Low, Kit-Lam Chan

Front Pharmacol· October 2015

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In vitro Xanthine Oxidase Inhibitory Studies of Lippia nodiflora and Isolated Flavonoids and Phenylethanoid Glycosides as Potential Uric Acid-lowering Agents.
Lee-Chuen Cheng, Vikneswaran Murugaiyah, Kit-Lam Chan

Nat Prod Commun· June 2015

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Blood-brain barrier permeable anticholinesterase aurones: synthesis, structure-activity relationship, and drug-like properties.
Kok-Fui Liew, Kit-Lam Chan, Chong-Yew Lee

Eur J Med Chem· April 2015

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A virtual screening approach for identifying plants with anti H5N1 neuraminidase activity.
Nur Kusaira Khairul Ikram, Jacob D Durrant, Muchtaridi Muchtaridi, Ayunni Salihah Zalaludin, Neny Purwitasari, Chan Kit Lam

J Chem Inf Model· February 2015

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Anti-tumor activity of Eurycoma longifolia root extracts against K-562 cell line: in vitro and in vivo study.
Omar Saeed Ali Al-Salahi, Dan Ji, Amin Malik Shah Abdul Majid, Chan Kit-Lam, Wan Zaidah Abdullah

PLoS One· September 2014

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Acute, reproductive toxicity and two-generation teratology studies of a standardized quassinoid-rich extract of Eurycoma longifolia Jack in Sprague-Dawley rats.
Bin-Seng Low, Prashanta Kumar Das, Kit-Lam Chan

Phytother Res· July 2014

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Isocorilagin, a cholinesterase inhibitor from Phyllanthus niruri.
Yee-Hui Koay, Alireza Basiri, Vikneswaran Murugaiyah, Kit-Lam Chan

Nat Prod Commun· April 2014

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Anti-angiogenic quassinoid-rich fraction from Eurycoma longifolia modulates endothelial cell function.
Omar Saeed Ali Al-Salahi, Chan Kit-Lam, Amin Malik Shah Abdul Majid, Fouad Saleih R Al-Suede, Sultan Ayesh Mohammed Saghir

Microvasc Res· November 2013

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Eurycomanone, the major quassinoid in Eurycoma longifolia root extract increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis.
Bin-Seng Low, Sy-Bing Choi, Habibah Abdul Wahab, Prashanta Kumar Das, Kit-Lam Chan

J Ethnopharmacol· August 2013

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Standardized quassinoid-rich Eurycoma longifolia extract improved spermatogenesis and fertility in male rats via the hypothalamic-pituitary-gonadal axis.
Bin-Seng Low, Prashanta Kumar Das, Kit-Lam Chan

J Ethnopharmacol· February 2013

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A response to the comments on the relevance of Eurycoma longifolia Jack to food and food chemistry.
Kit Lam Chan

Food Chem· October 2012

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