Publications by authors named "Changdev G Gadhe"

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Mice deficient in TWIK-1 are more susceptible to kainic acid-induced seizures.
Ajung Kim, Yeonju Bae, Changdev G Gadhe, Hyun-Gug Jung, Esther Yang

iScience· January 2025

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A novel small molecule, CU05-1189, targeting the pleckstrin homology domain of PDK1 suppresses VEGF-mediated angiogenesis and tumor growth by blocking the Akt signaling pathway.
Jeongeun Park, Haiying Zhang, Hyun Jung Kwak, Changdev Gorakshnath Gadhe, Yeomyeong Kim

Front Pharmacol· November 2023

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Development of F-Labeled PET Tracer Candidates for Imaging of the Abelson Non-receptor Tyrosine Kinase in Parkinson's Disease.
E Johanna L Stéen, A Yeong Park, Wissam Beaino, Changdev Gorakshnath Gadhe, Esther Kooijman

J Med Chem· September 2023

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Glutamate Permeability of Chicken Best1.
Jung Moo Lee, Changdev Gorakshnath Gadhe, Hyunji Kang, Ae Nim Pae, C Justin Lee

Exp Neurobiol· October 2022

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Correction to "A Novel, Selective c-Abl Inhibitor, Compound 5, Prevents Neurodegeneration in Parkinson's Disease".
Seung-Hwan Kwon, Sangjune Kim, A Yeong Park, Saebom Lee, Changdev Gorakshnath Gadhe

J Med Chem· December 2021

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A Novel, Selective c-Abl Inhibitor, Compound 5, Prevents Neurodegeneration in Parkinson's Disease.
Seung-Hwan Kwon, Sangjune Kim, A Yeong Park, Saebom Lee, Changdev Gorakshnath Gadhe

J Med Chem· October 2021

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PyrPeg, a Blood-Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates.
Ji-Woo Choi, Yeon Ha Ju, Yunsook Choi, Seung Jae Hyeon, Changdev G Gadhe

ACS Chem Neurosci· June 2020

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Structure-activity relationships of fluorene compounds inhibiting HCV variants.
Hee Sun Kim, Youngsu You, Jaegon Mun, Changdev G Gadhe, Heejo Moon

Antiviral Res· February 2020

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Development of Oxadiazole-Based ODZ10117 as a Small-Molecule Inhibitor of STAT3 for Targeted Cancer Therapy.
Byung-Hak Kim, Haeri Lee, Yeonghun Song, Joon-Suk Park, Changdev G Gadhe

J Clin Med· November 2019

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Investigation of Molecular Details of Keap1-Nrf2 Inhibitors Using Molecular Dynamics and Umbrella Sampling Techniques.
Ashwini Machhindra Londhe, Changdev Gorakshnath Gadhe, Sang Min Lim, Ae Nim Pae

Molecules· November 2019

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3-Carene, a Phytoncide from Pine Tree Has a Sleep-enhancing Effect by Targeting the GABA-benzodiazepine Receptors.
Junsung Woo, Hyejin Yang, Minseok Yoon, Changdev G Gadhe, Ae Nim Pae

Exp Neurobiol· October 2019

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Development of an Aryloxazole Derivative as a Brain-Permeable Anti-Glioblastoma Agent.
Seulgi Shin, Sungsu Lim, Ji Yeon Song, Dohee Kim, Min Jeong Choi, Changdev G Gadhe

Pharmaceutics· September 2019

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Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain.
Hak Kyun Yang, Woo Seung Son, Keon Seung Lim, Gun Hee Kim, Eun Jeong Lim, Changdev G Gadhe

J Enzyme Inhib Med Chem· December 2018

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Novel 5,6-disubstituted pyrrolo[2,3-d]pyrimidine derivatives as broad spectrum antiproliferative agents: Synthesis, cell based assays, kinase profile and molecular docking study.
Ju-Hyeon Lee, Ashraf K El-Damasy, Seon Hee Seo, Changdev G Gadhe, Ae Nim Pae

Bioorg Med Chem· November 2018

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Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease.
Ji Woong Lim, Seok Kyu Kim, Seo Yun Choi, Dong Hoi Kim, Changdev G Gadhe

Eur J Med Chem· September 2018

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A novel tropomyosin-related kinase A inhibitor, KK5101 to treat pancreatic cancer.
Zhenghuan Fang, Boreum Han, Kyung Hee Jung, Ju-Hyeon Lee, Ashraf Kareem El-Damasy, Changdev G Gadhe

Cancer Lett· July 2018

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In silico characterization of binding mode of CCR8 inhibitor: homology modeling, docking and membrane based MD simulation study.
Changdev G Gadhe, Anand Balupuri, Seung Joo Cho

J Biomol Struct Dyn· June 2016

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Finding new scaffolds of JAK3 inhibitors in public database: 3D-QSAR models & shape-based screening.
Changdev G Gadhe, Eunhee Lee, Mi-Hyun Kim

Arch Pharm Res· November 2015

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Modeling study of phenylsulfonylfuroxan derivatives as P-gp inhibitors: a combined approach of CoMFA, CoMSIA and HQSAR.
Changdev G Gadhe, Anand Balupuri, Pavithra K Balasubramanian, Seung Joo Cho

Anticancer Agents Med Chem· June 2015

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Insights into the binding modes of CC chemokine receptor 4 (CCR4) inhibitors: a combined approach involving homology modelling, docking, and molecular dynamics simulation studies.
Changdev G Gadhe, Mi-hyun Kim

Mol Biosyst· February 2015

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A Protoberberine derivative HWY336 selectively inhibits MKK4 and MKK7 in mammalian cells: the importance of activation loop on selectivity.
Namil Kim, Jeongyeon Park, Changdev G Gadhe, Seung Joo Cho, Youngjin Oh

PLoS One· January 2015

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The nociceptin receptor (NOPR) and its interaction with clinically important agonist molecules: a membrane molecular dynamics simulation study.
Gugan Kothandan, Changdev G Gadhe, Anand Balupuri, Jagadeesan Ganapathy, Seung Joo Cho

Mol Biosyst· December 2014

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In silico study on indole derivatives as anti HIV-1 agents: a combined docking, molecular dynamics and 3D-QSAR study.
Anand Balupuri, Changdev G Gadhe, Pavithra K Balasubramanian, Gugan Kothandan, Seung Joo Cho

Arch Pharm Res· August 2014

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Novel ionophores with 2n-crown-n topology: anion sensing via pure aliphatic C-H···anion hydrogen bonding.
Genggongwo Shi, Changdev G Gadhe, Sung-Woo Park, Kwang S Kim, Jongmin Kang

Org Lett· January 2014

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In silico study of desmosdumotin as an anticancer agent: homology modeling, docking and molecular dynamics simulation approach.
Changdev G Gadhe, Gugan Kothandan, Seung Joo Cho

Anticancer Agents Med Chem· December 2013

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