Publications by authors named "Changfa Fan"

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A novel immunocompetent transgenic mouse model of DHF reveals Syk-mediated Th2-polarized cytokine storm as a key driver of vascular leakage.
YuYa Wang, Wei Yang, YuanSong Yang, HuiHui Cheng, Rui Xiong, ChangFa Fan

Emerg Microbes Infect· December 2025

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Rapid generation of a murine RSV infectious model by transducing a conditional knock-in mouse harboring human IGF1 receptor with adenoviral vector.
Rui Xiong, Yong Wu, Yuya Wang, Zhe Qu, Yanwei Yang, Changfa Fan

Antiviral Res· December 2025

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A novel carcinogenic mouse model by site-directed insertion of tandem human HRAS large DNA fragment into 15E1 site.
Susu Liu, Yanwei Yang, Guitao Huo, Hao Yang Zhao, Chen Ling, Changfa Fan

Animal Model Exp Med· November 2025

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CVA16 infection causes neurological injury by engaging TLR2/MYD88/TNF-α/CXCL1 signalling pathway in hSCARB2 knock-in mice.
Yu Wang, Yong Wu, Yuya Wang, Rui Xiong, Chen Ling, Changfa Fan

Antiviral Res· May 2025

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Correction: Fan et al. A Human DPP4-Knockin Mouse's Susceptibility to Infection by Authentic and Pseudotyped MERS-CoV. 2018, , 448.
Changfa Fan, Xi Wu, Qiang Liu, Qianqian Li, Susu Liu

Viruses· March 2025

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Progress and challenges in development of animal models for dengue virus infection.
Wang Yuya, Yang Yuansong, Liu Susu, Ling Chen, Wu Yong, Fan Changfa

Emerg Microbes Infect· December 2024

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SUGP2 p.(Arg639Gln) variant is involved in the pathogenesis of hemochromatosis via the CIRBP/BMPER signaling pathway.
Yanmeng Li, Anjian Xu, Susu Liu, Wei Zhang, Donghu Zhou, Changfa Fan

Am J Hematol· September 2024

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Enterovirus A71 2A-S125A acts as an attenuated vaccine candidate, indicating a universal approach in developing enterovirus vaccines.
Peng Zhang, Wenjia Zou, Rui Xiong, Yong Wu, Changfa Fan

J Med Virol· August 2024

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The inoculum dose of Zika virus can affect the viral replication dynamics, cytokine responses and survival rate in immunocompromised AG129 mice.
Yuhuan Yan, Hao Yang, Yun Yang, Junbin Wang, Yanan Zhou, Changfa Fan

Mol Biomed· August 2024

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Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor.
Luo-Yuan Xia, Xue-Feng Wang, Xiao-Ming Cui, Yi-Ming Zhang, Zhen-Fei Wang, Chang-Fa Fan, Fang-Xu Li

Sci China Life Sci· July 2024

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Overexpression of wild-type HRAS drives non-alcoholic steatohepatitis to hepatocellular carcinoma in mice.
Chen Ling, Su-Su Liu, Yu-Ya Wang, Gui-Tao Huo, Yan-Wei Yang, Chang-Fa Fan

Zool Res· May 2024

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Development of a Bioluminescent Imaging Mouse Model for SARS-CoV-2 Infection Based on a Pseudovirus System.
Xi Wu, Nana Fang, Ziteng Liang, Jianhui Nie, Sen Lang, Changfa Fan

Vaccines (Basel)· June 2023

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Novel hKDR mouse model depicts the antiangiogenesis and apoptosis-promoting effects of neutralizing antibodies targeting vascular endothelial growth factor receptor 2.
Yuan Cao, Chunyun Sun, Guitao Huo, Huiyu Wang, Yong Wu, Changfa Fan

Cancer Sci· January 2023

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Phosphorylation of enteroviral 2A at Ser/Thr125 benefits its proteolytic activity and viral pathogenesis.
Yuya Wang, Wenjia Zou, Yan Niu, Sanyuan Wang, Bangtao Chen, Changfa Fan

J Med Virol· January 2023

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A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein.
Wei Pang, Ying Lu, Yan-Bo Zhao, Fan Shen, Chang-Fa Fan

Cell Res· December 2022

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Long-Term Infection and Pathogenesis in a Novel Mouse Model of Human Respiratory Syncytial Virus.
Rui Xiong, Rui Fu, Yong Wu, Xi Wu, Yuan Cao, Changfa Fan

Viruses· August 2022

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Animal models for COVID-19: advances, gaps and perspectives.
Changfa Fan, Yong Wu, Xiong Rui, Yuansong Yang, Chen Ling

Signal Transduct Target Ther· July 2022

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Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies.
Miao-Miao Zhao, Yun Zhu, Li Zhang, Gongxun Zhong, Linhua Tai, Changfa Fan

Cell Discov· June 2022

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Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells.
Weiqi Hong, Jingyun Yang, Jun Zou, Zhenfei Bi, Cai He, Changfa Fan

Cell Mol Immunol· May 2022

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Generation of a uniform thymic malignant lymphoma model with C57BL/6J gene deficient mice.
Susu Liu, Jianjun Lyu, Qianqian Li, Xi Wu, Yanwei Yang, Changfa Fan

J Toxicol Pathol· January 2022

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A new nairo-like virus associated with human febrile illness in China.
Yan-Chun Wang, Zhengkai Wei, Xiaolong Lv, Shuzheng Han, Zedong Wang, Changfa Fan

Emerg Microbes Infect· December 2021

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A practical method for evaluating the efficacy of EVA-71 vaccine using a hSCARB2 knock-in mouse model.
Yong Wu, Zhe Qu, Rui Xiong, Yanwei Yang, Susu Liu, Changfa Fan

Emerg Microbes Infect· December 2021

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The Infection and Pathogenicity of SARS-CoV-2 Variant B.1.351 in hACE2 Mice.
Qi Chen, Xing-Yao Huang, Ying Tian, Changfa Fan, Mengxu Sun

Virol Sin· October 2021

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Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2.
Ling Zhu, Yong-Qiang Deng, Rong-Rong Zhang, Zhen Cui, Chun-Yun Sun, Chang-Fa Fan

Natl Sci Rev· March 2021

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