Publications by authors named "Changhai Lei"

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Phenolic-Rich Grape Exosome-Like Nanoparticles: Evidence of Multivesicular Body Pathway Secretion and Therapeutic Effect on Oral Inflammation.
Xinya Zheng, Hongru Ai, Fangxing Lin, Yaping Zhou, Gangyao Li, Changhai Lei

FASEB J· January 2026

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Protective effects of an Fc-engineered PD-L1 fusion protein in a spontaneous abortion model and a Th17 cell-induced pregnancy loss model.
Guangyao Li, Tiantian Wang, Dan Tan, Yamin Jin, Xuemei Zhou, Changhai Lei

Front Pharmacol· December 2025

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Dual-target immunotherapies in NSCLC: a systematic review and meta-analysis of randomized clinical trials.
Yike Zhang, Haozhe Wang, Xinyue Yang, Changhai Lei

Front Immunol· September 2025

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T-Cell-Dependent Bispecific IgGs Protect Aged Mice From Lethal SARS-CoV-2 Infection.
Wenyan Fu, Wei Zhang, Zhongshuai You, Guangyao Li, Chuqi Wang, Changhai Lei

Adv Sci (Weinh)· April 2025

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Development and characterization of a novel neutralizing scFv vectored immunoprophylaxis against botulinum toxin type A.
Yongpeng Wei, Guangyao Li, Zhuo Wang, Kewen Qian, Shuyi Zhang, Changhai Lei

J Drug Target· December 2024

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Exosomes derived from cancer cells relieve inflammatory bowel disease in mice.
Shuyi Zhang, Guangyao Li, Kewen Qian, Yitan Zou, Xinya Zheng, Changhai Lei

J Drug Target· November 2024

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Exosomes: the next frontier in vaccine development and delivery.
Dan Tan, Guangyao Li, Wenyan Fu, Changhai Lei

Front Immunol· July 2024

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The therapeutic potential of exosomes in immunotherapy.
Guangyao Li, Shuyi Zhang, Yitan Zou, Hongru Ai, Xinya Zheng, Changhai Lei

Front Immunol· July 2024

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Small extracellular vesicles purification and scale-up.
Xinya Zheng, Hongru Ai, Kewen Qian, Guangyao Li, Shuyi Zhang, Changhai Lei

Front Immunol· March 2024

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Bispecific antibodies targeting EGFR/Notch enhance the response to talazoparib by decreasing tumour-initiating cell frequency.
Wenyan Fu, Guangyao Li, Changhai Lei, Kewen Qian, Shuyi Zhang

Theranostics· July 2023

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Engineered soluble ACE2 receptor: Responding to change with change.
Guangyao Li, Kewen Qian, Shuyi Zhang, Wenyan Fu, Jian Zhao, Changhai Lei

Front Immunol· February 2023

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The roles of small extracellular vesicles in cancer and immune regulation and translational potential in cancer therapy.
Kewen Qian, Wenyan Fu, Tian Li, Jian Zhao, Changhai Lei

J Exp Clin Cancer Res· September 2022

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Synthetic libraries of immune cells displaying a diverse repertoire of chimaeric antigen receptors as a potent cancer immunotherapy.
Wenyan Fu, Changhai Lei, Chuqi Wang, Zetong Ma, Tian Li

Nat Biomed Eng· July 2022

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Generation and functional characterization of CAR exosomes.
Chuqi Wang, Wenyan Fu, Changhai Lei, Shi Hu

Methods Cell Biol· April 2022

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Therapeutic antibodies under development for SARS-CoV-2.
Zetong Ma, MengMei Zhu, Shuyi Zhang, Kewen Qian, Chuqi Wang, Changhai Lei

View (Beijing)· March 2022

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TIGIT-Fc as a Potential Therapeutic Agent for Fetomaternal Tolerance.
Wenyan Fu, Renfei Cai, Zetong Ma, Tian Li, Changhai Lei

Front Immunol· September 2021

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TIGIT-Fc Promotes Antitumor Immunity.
Xian Shen, Wenyan Fu, Yongpeng Wei, Junle Zhu, Yue Yu, Changhai Lei

Cancer Immunol Res· September 2021

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CAR Macrophages for SARS-CoV-2 Immunotherapy.
Wenyan Fu, Changhai Lei, Zetong Ma, Kewen Qian, Tian Li

Front Immunol· August 2021

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Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig.
Changhai Lei, Kewen Qian, Tian Li, Sheng Zhang, Wenyan Fu

Nat Commun· April 2020

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CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity.
Wenyan Fu, Changhai Lei, Shuowu Liu, Yingshu Cui, Chuqi Wang

Nat Commun· September 2019

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Targeting RyR2 with a phosphorylation site-specific nanobody reverses dysfunction of failing cardiomyocytes in rats.
Tian Li, Yafeng Shen, Fangxing Lin, Wenyan Fu, Shuowu Liu, Changhai Lei

FASEB J· June 2019

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Treatment of murine lupus with TIGIT-Ig.
Shuowu Liu, Lizhu Sun, Chuqi Wang, Yingshu Cui, Yuee Ling, Changhai Lei

Clin Immunol· June 2019

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EGFR/Notch Antagonists Enhance the Response to Inhibitors of the PI3K-Akt Pathway by Decreasing Tumor-Initiating Cell Frequency.
Wenyan Fu, Changhai Lei, Yue Yu, Shuowu Liu, Tian Li

Clin Cancer Res· May 2019

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Cardiac adenovirus-associated viral Presenilin 1 gene delivery protects the left ventricular function of the heart via regulating RyR2 function in post-ischaemic heart failure.
Tian Li, Yafeng Shen, Li Su, Xiaoyan Fan, Fangxing Lin, Changhai Lei

J Drug Target· December 2018

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Conditionally targeted deletion of PSEN1 leads to diastolic heart dysfunction.
Xiao-Wei Song, Qing-Ning Yuan, Ying Tang, Mi Cao, Ya-Feng Shen, Chang-Hai Lei

J Cell Physiol· February 2018

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