Publications by authors named "Charles Craik"

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Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models.
Luca Lizzadro, Jiapeng Li, Taha Y Taha, Gilles Degotte, Tyler C Detomasi, Charles S Craik

J Med Chem· January 2026

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Post-vaccination SARS-CoV-2 neutralizing antibodies in pregnant women receiving biologics for inflammatory bowel disease.
Donna E Leet, Jing Jin, Charles S Craik, Michael G Kattah, Millie D Long

PLoS One· December 2025

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Precision Labeling of Native Antibodies with Lock Coupling.
Yazhi Liu, Isha Nadig, Abijeet Singh Mehta, Shih-Wei Chuo, Yen H Ho, Charles S Craik

J Am Chem Soc· December 2025

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Identifying protease-activated targets and exploring therapeutic applications.
Deokhee Kang, Charles S Craik

Expert Opin Ther Targets· October 2025

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Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors.
Bryan J Fraser, Nicholas J Young, Brian J Bender, Stefan Gahbauer, Olzhas Ilyassov, Charles S Craik

J Med Chem· October 2025

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Antibody Reveals Conformational Latch Controlling Herpesvirus Proteases.
Marcell Zimanyi, Kaitlin R Hulce, Markus-Frederik Bohn, Jordan Norman, Peter J Rohweder, Charles S Craik

bioRxiv· October 2025

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On-Resin Assembly of Macrocyclic Inhibitors of May1: A Pathway to Potent Antifungal Agents.
Robin Kryštůfek, Václav Verner, Pavel Šácha, Martin Hadzima, Filip Trajhan, Charles S Craik

J Med Chem· May 2025

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Structures of Fab-stabilized CHIP reveal a conformational switch important in E3 ligase and chaperone functions.
Aparna Unnikrishnan, Dong Hee Chung, Emily J Connelly, Shih-Wei Chuo, Shweta Devi, Charles S Craik

bioRxiv· May 2025

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Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus M inhibitors with potent in vivo efficacy.
Tyler C Detomasi, Gilles Degotte, Sijie Huang, Rahul K Suryawanshi, Amy Diallo, Charles S Craik

Sci Adv· April 2025

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Recombinant antibodies inhibit enzymatic activity of the E3 ubiquitin ligase CHIP via multiple mechanisms.
Dong Hee Chung, Emily J Connelly, Aparna Unnikrishnan, Shih-Wei Chuo, Kristin Wucherer, Charles S Craik

J Biol Chem· March 2025

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Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.
Aakriti Jain, Isaac Heremans, Gilles Rademaker, Tyler C Detomasi, Peter Rohweder, Charles S Craik

Science· March 2025

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Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C-MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies.
Apurva Pandey, Peter J Rohweder, Lieza M Chan, Chayanid Ongpipattanakul, Dong Hee Chung, Charles S Craik

Cancer Res· January 2025

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Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.
Aakriti Jain, Isaac Heremans, Gilles Rademaker, Tyler C Detomasi, Grace A Hernandez, Charles S Craik

bioRxiv· December 2024

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Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP.
Cory M Nadel, Saugat Pokhrel, Kristin Wucherer, Abby Oehler, Aye C Thwin, Charles S Craik

Nat Commun· September 2024

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Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin.
Matthew W Mahoney, Jonathan Helander, Anoopjit S Kooner, Mariah Norman, Vishnu C Damalanka, Charles S Craik

Protein Sci· August 2024

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Imaging the Granzyme Mediated Host Immune Response to Viral and Bacterial Pathogens Using Positron Emission Tomography.
Apurva Pandey, Shalini Chopra, Simon J Cleary, Marina López-Álvarez, Fiona M Quimby, Charles S Craik

ACS Infect Dis· June 2024

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Structural basis of prostaglandin efflux by MRP4.
Sergei Pourmal, Evan Green, Ruchika Bajaj, Ilan E Chemmama, Giselle M Knudsen, Charles S Craik

Nat Struct Mol Biol· April 2024

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Proteases influence colony aggregation behavior in Vibrio cholerae.
Tyler C Detomasi, Allison E Batka, Julie S Valastyan, Molly A Hydorn, Charles S Craik

J Biol Chem· December 2023

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Preparing for the next pandemic.
Brian K Shoichet, Charles S Craik

Science· November 2023

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Rare antibody phage isolation and discrimination (RAPID) biopanning enables identification of high-affinity antibodies against challenging targets.
Dong Hee Chung, Sophie Kong, Nicholas J Young, Shih-Wei Chuo, Jamie V Shiah, Charles S Craik

Commun Biol· October 2023

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Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors.
Elissa A Fink, Conner Bardine, Stefan Gahbauer, Isha Singh, Tyler C Detomasi, Charles S Craik

Protein Sci· August 2023

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Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP.
Cory M Nadel, Kristin Wucherer, Abby Oehler, Aye C Thwin, Koli Basu, Charles S Craik

bioRxiv· August 2023

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The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT).
Cory M Nadel, Aye C Thwin, Matthew Callahan, Kanghyun Lee, Emily Connelly, Charles S Craik

J Mol Biol· June 2023

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Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors.
Priyanka Rashmi, Tara K Sigdel, Dmitry Rychkov, Izabella Damm, Andrea Alice Da Silva, Charles S Craik

Ann Transl Med· June 2023

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A Prototype Assay Multiplexing SARS-CoV-2 3CL-Protease and Angiotensin-Converting Enzyme 2 for Saliva-Based Diagnostics in COVID-19.
Vallabh Suresh, Daniel A Sheik, Tyler C Detomasi, Tianqi Zhao, Theresa Zepeda, Charles S Craik

Biosensors (Basel)· June 2023

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