Publications by authors named "Charles Large"

Claim this Profile

Mentions over time

Mentions by platform

Video Views

252

Total Likes

323

Extended Reach

425,867

Social Features

155
K
Kv3 channel agonist ameliorates the phenotype of a mouse model of amyotrophic lateral sclerosis.
Manuela Marabita, Caterina Marchioretti, Aishwarya Aravamudhan, Simona Zito, Antonella Falconieri, Charles H Large

Acta Neuropathol Commun· July 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The binding and mechanism of a positive allosteric modulator of Kv3 channels.
Qiansheng Liang, Gamma Chi, Leonardo Cirqueira, Lianteng Zhi, Agostino Marasco, Charles H Large

Nat Commun· March 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy.
Huijie Feng, Jerome Clatot, Keisuke Kaneko, Marco Flores-Mendez, Eric R Wengert, Charles H Large

Cell Rep Med· February 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacological modulation of Kv3 voltage-gated potassium channels regulates fear discrimination and expression in a response-dependent manner.
Christine Stubbendorff, Ed Hale, Harriet L L Day, Jessica Smith, Giuseppe S Alvaro, Charles H Large

Prog Neuropsychopharmacol Biol Psychiatry· December 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The effects of AUT00206, a novel Kv3.1/3.2 potassium channel modulator, on task-based reward system activation: a test of mechanism in schizophrenia.
Stephen J Kaar, Ilinca Angelescu, Matthew M Nour, Tiago Reis Marques, Alice Sharman, Charles Large

Psychopharmacology (Berl)· October 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The effect of AUT00206, a Kv3 potassium channel modulator, on dopamine synthesis capacity and the reliability of [F]-FDOPA imaging in schizophrenia.
Ilinca Angelescu, Stephen J Kaar, Tiago Reis Marques, Faith Borgan, Mattia Veronesse, Charles Large

J Psychopharmacol· September 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
K
Kv3 Channels Contribute to the Excitability of Subpopulations of Spinal Cord Neurons in Lamina VII.
Pierce N Mullen, Nadia Pilati, Charles H Large, Jim Deuchars, Susan A Deuchars

eNeuro· April 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease.
Jie Yeap, Chaitra Sathyaprakash, Jamie Toombs, Jane Tulloch, Cristina Scutariu, Charles H Large

Brain Neurosci Adv· March 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Sparsely Distributed, Pre-synaptic Kv3 K Channels Control Spontaneous Firing and Cross-Unit Synchrony via the Regulation of Synaptic Noise in an Auditory Brainstem Circuit.
Timothy OIsen, Alberto Capurro, Maša Švent, Nadia Pilati, Charles Large

Front Cell Neurosci· September 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Effect of Kv3 channel modulators on auditory temporal resolution in aged Fischer 344 rats.
Natalia Rybalko, Jiří Popelář, Daniel Šuta, Jana Svobodová Burianová, Giuseppe S Alvaro, Charles H Large

Hear Res· March 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia.
David R Witty, Giuseppe Alvaro, Dominique Derjean, Gerard M P Giblin, Kevin Gunn, Charles Large

ACS Med Chem Lett· September 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Modulators of Kv3 Potassium Channels Rescue the Auditory Function of Fragile X Mice.
Lynda El-Hassar, Lei Song, Winston J T Tan, Charles H Large, Giuseppe Alvaro

J Neurosci· June 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: The QUIET-1 trial.
Deborah A Hall, Jaydip Ray, Jeannette Watson, Alice Sharman, John Hutchison, Charles H Large

Hear Res· June 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Evaluation of Possible Effects of a Potassium Channel Modulator on Temporal Processing by Cochlear Implant Listeners.
Robert P Carlyon, John M Deeks, François Guérit, Wiebke Lamping, Alexander J Billig, Charles H Large

J Assoc Res Otolaryngol· December 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Increased spontaneous firing rates in auditory midbrain following noise exposure are specifically abolished by a Kv3 channel modulator.
Lucy A Anderson, Lara L Hesse, Nadia Pilati, Warren M H Bakay, Giuseppe Alvaro, Charles H Large

Hear Res· August 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
K
Kv3 K currents contribute to spike-timing in dorsal cochlear nucleus principal cells.
Timothy Olsen, Alberto Capurro, Nadia Pilati, Charles H Large, Martine Hamann

Neuropharmacology· May 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Effects of AUT00063, a Kv3.1 channel modulator, on noise-induced hyperactivity in the dorsal cochlear nucleus.
Lyall Glait, Weiwen Fan, Gina Stillitano, Sharon Sandridge, Nadia Pilati, Charles Large

Hear Res· April 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Antimanic Efficacy of a Novel Kv3 Potassium Channel Modulator.
Puja K Parekh, Michelle M Sidor, Andrea Gillman, Darius Becker-Krail, Letizia Bettelini, Charles H Large

Neuropsychopharmacology· January 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacological modulation of Kv3.1 mitigates auditory midbrain temporal processing deficits following auditory nerve damage.
Anna R Chambers, Nadia Pilati, Pooja Balaram, Charles H Large, Leonard K Kaczmarek

Sci Rep· December 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons.
Maile R Brown, Lynda El-Hassar, Yalan Zhang, Giuseppe Alvaro, Charles H Large

J Neurophysiol· July 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
K
Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating.
Yalan Zhang, Xiao-Feng Zhang, Matthew R Fleming, Anahita Amiri, Lynda El-Hassar, Charles H Large

Cell· April 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons.
Marcelo D Rosato-Siri, Erika Zambello, Chiara Mutinelli, Nicoletta Garbati, Roberto Benedetti, Charles H Large

J Pharmacol Exp Ther· September 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Mechanisms contributing to central excitability changes during hearing loss.
Nadia Pilati, Matias J Ison, Matthew Barker, Mike Mulheran, Charles H Large

Proc Natl Acad Sci U S A· May 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: implications for clinical use.
Charles H Large, David M Sokal, Astrid Nehlig, Martin J Gunthorpe, Raman Sankar

Epilepsia· March 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis