Publications by authors named "Charles Minto"

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Association of intraoperative hypotension and cumulative norepinephrine dose with postoperative acute kidney injury in patients having noncardiac surgery: causal implications of the drug titration paradox. Br J Anaesth 2025; 134: 54-62.
Thomas W Schnider, Charles F Minto, Jamie W Sleigh

Br J Anaesth· January 2026

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Implementation transparency in target-controlled infusion systems: balancing innovation with verification.
Charles F Minto, Thomas W Schnider, Paul Sinclair

J Clin Monit Comput· December 2025

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Genome-wide Study on Propofol Requirements: Comment.
Thomas W Schnider, Talmage D Egan, Charles F Minto

Anesthesiology· March 2025

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Steady-state trumps accuracy: target-controlled infusion as a gain switch.
Talmage D Egan, Charles F Minto, Thomas W Schnider

Br J Anaesth· October 2024

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Drug Titration Paradox: Reply.
Charles F Minto, Talmage D Egan, Thomas W Schnider

Anesthesiology· August 2024

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Drug Titration Paradox: An Emerging Concept in Clinical Pharmacology.
Charles F Minto, Talmage D Egan, Thomas W Schnider

Anesthesiology· January 2024

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Variability of predicted propofol concentrations and measured sevoflurane concentrations during general anaesthesia: a single-centre retrospective cohort study.
Thomas W Schnider, Charles F Minto

Br J Anaesth· October 2023

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Mixed-effects models and the drug titration paradox.
Charles F Minto, Thomas W Schnider

CPT Pharmacometrics Syst Pharmacol· April 2023

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The drug titration paradox: more drug does not correlate with more effect in individual clinical data.
Thomas W Schnider, Charles F Minto, Martin Luginbühl, Talmage D Egan

Br J Anaesth· December 2022

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Beware the drug titration paradox. Comment on Br J Anaesth 2021; 127: 704-12.
Thomas W Schnider, Charles F Minto

Br J Anaesth· June 2022

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The Drug Titration Paradox: Correlation of More Drug With Less Effect in Clinical Data.
Thomas W Schnider, Charles F Minto, Miodrag Filipovic

Clin Pharmacol Ther· August 2021

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Clinical validation of pharmacokinetic and pharmacodynamic models for propofol infusion. Comment on Br J Anaesth 2021; 126: 386-94.
Thomas W Schnider, Charles F Minto, Talmage D Egan, Miodrag Filipovic

Br J Anaesth· May 2021

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Relationship Between Propofol Target Concentrations, Bispectral Index, and Patient Covariates During Anesthesia.
Thomas W Schnider, Charles F Minto, Talmage D Egan, Miodrag Filipovic

Anesth Analg· March 2021

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Moving from dose to concentration: as easy as TCI!
Talmage D Egan, Martin Westphal, Charles F Minto, Thomas W Schnider

Br J Anaesth· December 2020

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Patient Factors Affecting Bispectral Index During Total Intravenous Anesthesia With Target-Controlled Infusion.
Thomas W Schnider, Charles F Minto, Talmage D Egan, Miodrag Filipovic

Anesth Analg· September 2020

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Correlation between bispectral index and age-adjusted minimal alveolar concentration.
Thomas W Schnider, Charles F Minto, Talmage D Egan, Miodrag Filipovic

Br J Anaesth· January 2020

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Disposition of Remifentanil in Obesity: A New Pharmacokinetic Model Incorporating the Influence of Body Mass.
Tae Kyun Kim, Shinju Obara, Talmage D Egan, Charles F Minto, Luca La Colla

Anesthesiology· June 2017

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The Safety of Target-Controlled Infusions.
Thomas W Schnider, Charles F Minto, Michel M R F Struys, Anthony R Absalom

Anesth Analg· January 2016

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Context sensitive decrement times of remimazolam.
Thomas Schnider, Charles Minto

Anesth Analg· July 2013

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Response surface modelling of drug interactions.
Charles Minto, Jaap Vuyk

Adv Exp Med Biol· May 2004

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Age related changes of the PK-PD of intravenous anaesthetics.
Thomas W Schnider, Charles F Minto

Adv Exp Med Biol· May 2004

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Using the time of maximum effect site concentration to combine pharmacokinetics and pharmacodynamics.
Charles F Minto, Thomas W Schnider, Keith M Gregg, Thomas K Henthorn, Steven L Shafer

Anesthesiology· August 2003

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Efficient trial design for eliciting a pharmacokinetic-pharmacodynamic model-based response surface describing the interaction between two intravenous anesthetic drugs.
Timothy G Short, Tam Yuk Ho, Charles F Minto, Thomas W Schnider, Steven L Shafer

Anesthesiology· February 2002

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