Publications by authors named "Charles Pyke"

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Liraglutide upregulates the Cftr gene and regulates the mucus transcriptome profile in Brunner's glands in mice.
Louise Marie Voetmann, Bidda Rolin, Rikke Kaae Kirk, Lotte Bjerre Knudsen, Myrte Merkestein, Charles Pyke

Clin Transl Med· November 2025

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Mapping atherogenesis mechanisms in smooth muscle cells by targeting genes linked to coronary artery disease.
Julián Albarrán-Juárez, Anton Markov, Anne Louise Jensen, Peter Loof Møller, Anna Katarzyna Uryga, Charles Pyke

iScience· November 2025

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A comprehensive spatio-cellular map of the human hypothalamus.
John A Tadross, Lukas Steuernagel, Georgina K C Dowsett, Katherine A Kentistou, Sofia Lundh, Charles Pyke

Nature· March 2025

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Author Correction: A comprehensive spatio-cellular map of the human hypothalamus.
John A Tadross, Lukas Steuernagel, Georgina K C Dowsett, Katherine A Kentistou, Sofia Lundh, Charles Pyke

Nature· March 2025

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Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis.
Tore Bleckwehl, Anne Babler, Merel Tebens, Sidrah Maryam, Michael Nyberg, Charles Pyke

Nat Cardiovasc Res· January 2025

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Smooth muscle-specific deletion of cellular communication network factor 2 causes severe aorta malformation and atherosclerosis.
Jannik H Larsen, Julie S Hegelund, Matilde K Pedersen, Cecilie M Andersson, Caroline A Lindegaard, Charles Pyke

Cardiovasc Res· December 2024

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coexpressing neurons modulate the suppression of food intake and body weight by a GLP-1/leptin dual agonist.
Joseph Polex-Wolf, Kristine Deibler, Wouter Frederik Johan Hogendorf, Sarah Bau, Tine Glendorf, Charles Pyke

Sci Transl Med· December 2024

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A systematic evaluation of state-of-the-art deconvolution methods in spatial transcriptomics: insights from cardiovascular disease and chronic kidney disease.
Alban Obel Slabowska, Charles Pyke, Henning Hvid, Leon Eyrich Jessen, Simon Baumgart

Front Bioinform· March 2024

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The intestinal permeability marker FITC-dextran 4kDa should be dosed according to lean body mass in obese mice.
Louise M Voetmann, Bidda Rolin, Rikke K Kirk, Charles Pyke, Axel K Hansen

Nutr Diabetes· January 2023

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Semaglutide treatment attenuates vessel remodelling in ApoE-/- mice following vascular injury and blood flow perturbation.
Ditte Marie Jensen, Gry Freja Skovsted, Mathilde Frederikke Bjørn Bonde, Jacob Fog Bentzon, Bidda Rolin, Charles Pyke

Atheroscler Plus· August 2022

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In vitro cell cultures of Brunner's glands from male mouse to study GLP-1 receptor function.
Louise M Voetmann, Christina R Underwood, Bidda Rolin, Axel K Hansen, Rikke K Kirk, Charles Pyke

Am J Physiol Cell Physiol· June 2022

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Glucagon-Like Peptide-1 Regulates the Proopiomelanocortin Neurons of the Arcuate Nucleus both Directly and Indirectly via Presynaptic Action.
Zoltán Péterfi, Anett Szilvásy-Szabó, Erzsébet Farkas, Yvette Ruska, Charles Pyke

Neuroendocrinology· January 2022

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Expression Profile of the GLP-1 Receptor in the Gastrointestinal Tract and Pancreas in Adult Female Mice.
Kaare V Grunddal, Elisa P Jensen, Cathrine Ørskov, Daniel B Andersen, Johanne A Windeløv, Charles Pyke

Endocrinology· January 2022

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A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing.
Georgina K C Dowsett, Brian Y H Lam, John A Tadross, Irene Cimino, Debra Rimmington, Charles Pyke

Mol Metab· November 2021

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Liraglutide Improves the Kidney Function in a Murine Model of Chronic Kidney Disease.
Maria E Ougaard, Frederikke E Sembach, Henrik E Jensen, Charles Pyke, Lotte B Knudsen

Nephron· October 2021

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Activation of the renal GLP-1R leads to expression of in the renal vascular tree.
Katrine Dahl Bjørnholm, Maria Elm Ougaard, Gry Freja Skovsted, Lotte Bjerre Knudsen, Charles Pyke

Endocrinol Diabetes Metab· July 2021

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A genetic map of the mouse dorsal vagal complex and its role in obesity.
Mette Q Ludwig, Wenwen Cheng, Desiree Gordian, Julie Lee, Sarah J Paulsen, Charles Pyke

Nat Metab· April 2021

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Automated ISH for Validated Histological Mapping of Lowly Expressed Genes.
Charles Pyke

Methods Mol Biol· March 2021

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Decreased expression of the GLP-1 receptor after segmental artery injury in mice.
Katrine Dahl Bjørnholm, Gro Klitgaard Povlsen, Maria Elm Ougaard, Charles Pyke, Günaj Rakipovski

J Endocrinol· March 2021

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Distribution and ultrastructural localization of the glucagon-like peptide-1 receptor (GLP-1R) in the rat brain.
Erzsébet Farkas, Anett Szilvásy-Szabó, Yvette Ruska, Richárd Sinkó, Morten Grønbech Rasch, Charles Pyke

Brain Struct Funct· January 2021

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Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission.
Marie A Bentsen, Dylan M Rausch, Zaman Mirzadeh, Kenjiro Muta, Jarrad M Scarlett, Charles Pyke

Nat Commun· September 2020

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Semaglutide lowers body weight in rodents via distributed neural pathways.
Sanaz Gabery, Casper G Salinas, Sarah J Paulsen, Jonas Ahnfelt-Rønne, Tomas Alanentalo, Charles Pyke

JCI Insight· March 2020

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Long-acting CCK analogue NN9056 lowers food intake and body weight in obese Göttingen Minipigs.
Berit Ø Christoffersen, Rikke Bjerring Skyggebjerg, Anne Bugge, Rikke Kaae Kirk, Bill Vestergaard, Charles Pyke

Int J Obes (Lond)· February 2020

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Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist.
Stephen T Buckley, Tine A Bækdal, Andreas Vegge, Stine J Maarbjerg, Charles Pyke

Sci Transl Med· November 2018

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Glucagon-like peptide-1 receptor expression in the human eye.
Josephine B Hebsgaard, Charles Pyke, Emre Yildirim, Lotte B Knudsen, Steffen Heegaard

Diabetes Obes Metab· September 2018

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