Publications by authors named "Charles Sinclair"

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A linear ontogeny accounts for the development of naive, memory, and tumor-infiltrating regulatory T cells in mice.
Sanmoy Pathak, Thea Hogan, Sanket Rane, Yundi Huang, Claire Pearson, Charles Sinclair

Sci Immunol· June 2025

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A linear ontogeny accounts for the development of naive, memory and tumour-infiltrating regulatory T cells in mice.
Sanmoy Pathak, Thea Hogan, Sanket Rane, Yundi Huang, Charles Sinclair

bioRxiv· July 2024

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Applications of Flow Cytometry in Drug Discovery and Translational Research.
Sumana Ullas, Charles Sinclair

Int J Mol Sci· March 2024

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Longitudinal tracking of T cell lymphomas in mice using flow cytometry.
Elizabeth A Kuczynski, Larissa Carnevalli, Charles Sinclair

STAR Protoc· March 2023

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A preclinical model of peripheral T-cell lymphoma GATA3 reveals DNA damage response pathway vulnerability.
Elizabeth A Kuczynski, Giulia Morlino, Alison Peter, Anna M L Coenen-Stass, Jennifer I Moss, Charles Sinclair

EMBO Mol Med· June 2022

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Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer.
Alexey Revenko, Larissa S Carnevalli, Charles Sinclair, Ben Johnson, Alison Peter

J Immunother Cancer· April 2022

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The future of immune checkpoint combinations with tumor-targeted small molecule drugs.
Jaclyn Sceneay, Charles Sinclair

Emerg Top Life Sci· November 2021

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PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8 T-cell activity.
Larissa S Carnevalli, Charles Sinclair, Molly A Taylor, Pablo Morentin Gutierrez, Sophie Langdon

J Immunother Cancer· December 2018

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Combination of dual mTORC1/2 inhibition and immune-checkpoint blockade potentiates anti-tumour immunity.
Sophie Langdon, Adina Hughes, Molly A Taylor, Elizabeth A Kuczynski, Deanna A Mele, Charles Sinclair

Oncoimmunology· May 2018

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mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation.
Charles Sinclair, Gayathri Bommakanti, Luiz Gardinassi, Jens Loebbermann, Matthew Joseph Johnson

Science· September 2017

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A Zap70-dependent feedback circuit is essential for efficient selection of CD4 lineage thymocytes.
Charles Sinclair, Masahiro Ono, Benedict Seddon

Immunol Cell Biol· April 2015

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Differential requirement for IL-2 and IL-15 during bifurcated development of thymic regulatory T cells.
Daniel Marshall, Charles Sinclair, Sim Tung, Benedict Seddon

J Immunol· December 2014

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Overlapping and asymmetric functions of TCR signaling during thymic selection of CD4 and CD8 lineages.
Charles Sinclair, Benedict Seddon

J Immunol· June 2014

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Translating glycolytic metabolism to innate immunity in dendritic cells.
Mario Cortese, Charles Sinclair, Bali Pulendran

Cell Metab· May 2014

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Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system.
Charles Sinclair, Iren Bains, Andrew J Yates, Benedict Seddon

Proc Natl Acad Sci U S A· July 2013

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Implementation of nurse authorisation of blood components.
Elizabeth S Pirie, Charles Sinclair

Br J Nurs· February 2013

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The long-term survival potential of mature T lymphocytes is programmed during development in the thymus.
Charles Sinclair, Manoj Saini, Ina Schim van der Loeff, Shimon Sakaguchi, Benedict Seddon

Sci Signal· November 2011

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Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells.
Andrea J White, Kyoko Nakamura, William E Jenkinson, Manoj Saini, Charles Sinclair

J Immunol· October 2010

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Regulation of Zap70 expression during thymocyte development enables temporal separation of CD4 and CD8 repertoire selection at different signaling thresholds.
Manoj Saini, Charles Sinclair, Daniel Marshall, Mauro Tolaini, Shimon Sakaguchi

Sci Signal· March 2010

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Maximum achievable beam brightness from photoinjectors.
Ivan V Bazarov, Bruce M Dunham, Charles K Sinclair

Phys Rev Lett· March 2009

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Efficient temporal shaping of ultrashort pulses with birefringent crystals.
Shian Zhou, Dimitre Ouzounov, Heng Li, Ivan Bazarov, Bruce Dunham, Charles Sinclair

Appl Opt· December 2007

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