Publications by authors named "Chase L Beisel"

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An updated evolutionary classification of CRISPR-Cas systems including rare variants.
Kira S Makarova, Sergey A Shmakov, Yuri I Wolf, Pascal Mutz, Han Altae-Tran, Chase L Beisel

Nat Microbiol· December 2025

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A resurrected ancestor of Cas12a expands target access and substrate recognition for nucleic acid editing and detection.
Ylenia Jabalera, Igor Tascón, Sara Samperio, Jorge P López-Alonso, Monika Gonzalez-Lopez, Chase L Beisel

Nat Biotechnol· October 2025

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Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes.
Darshana Gupta, Constantinos Patinios, Harris V Bassett, Anuja Kibe, Scott P Collins, Chase L Beisel

Nat Biotechnol· September 2025

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YprA family helicases provide the missing link between diverse prokaryotic immune systems.
Ryan T Bell, Thomas Gaudin, Yi Wu, Sofya K Garushyants, Harutyun Sahakyan, Chase L Beisel

bioRxiv· September 2025

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PAM-interacting domain turn-helix 51 motifs can improve Cas9-SpRY activity.
Reto Eggenschwiler, Thomas Hoffmann, Oleg Dmytrenko, Mika Opitz, Marlene Ackel-Zakour, Chase L Beisel

Nucleic Acids Res· August 2025

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Cas9-independent tracrRNA cytotoxicity in .
Adini Q Arifah, Justin M Vento, Isabella Kurrer, Tatjana Achmedov, Chase L Beisel

Microlife· July 2025

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Streamlined and efficient genome editing in Cupriavidus necator H16 using an optimised SIBR-Cas system.
Simona Della Valle, Enrico Orsi, Sjoerd C A Creutzburg, Luc F M Jansen, Evangelia-Niki Pentari, Chase L Beisel

Trends Biotechnol· June 2025

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Purification and in vivo, cell-free, and in vitro characterization of CRISPR-Cas12a2.
Friso T Schut, Thomson Hallmark, Oleg Dmytrenko, Ryan N Jackson, Chase L Beisel

Methods Enzymol· May 2025

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Disparate mechanisms counteract extraneous CRISPR RNA production in type II-C CRISPR-Cas systems.
Maximilian Feussner, Angela Migur, Alexander Mitrofanov, Omer S Alkhnbashi, Rolf Backofen, Chase L Beisel

Microlife· May 2025

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AcrVIB1 inhibits CRISPR-Cas13b immunity by promoting unproductive crRNA binding accessible to RNase attack.
Katharina G Wandera, Stefan Schmelz, Angela Migur, Anuja Kibe, Peer Lukat, Chase L Beisel

Mol Cell· March 2025

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Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes.
Constantinos Patinios, Darshana Gupta, Harris V Bassett, Scott P Collins, Charlotte Kamm, Chase L Beisel

bioRxiv· November 2024

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Phages to the rescue: in situ editing of the gut microbiota.
Charlotte Kamm, Chase L Beisel

Trends Microbiol· October 2024

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Ten Years of the Synthetic Biology Summer Course at Cold Spring Harbor Laboratory.
Karmella A Haynes, Lauren B Andrews, Chase L Beisel, James Chappell, Christian E Cuba Samaniego

ACS Synth Biol· September 2024

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MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in the Drosophila gut during inflammation.
Aranzazu Arias-Rojas, Adini Q Arifah, Georgia Angelidou, Belal Alshaar, Ursula Schombel, Chase L Beisel

PLoS Pathog· August 2024

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A cell-free transcription-translation pipeline for recreating methylation patterns boosts DNA transformation in bacteria.
Justin M Vento, Deniz Durmusoglu, Tianyu Li, Constantinos Patinios, Sean Sullivan, Chase L Beisel

Mol Cell· July 2024

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Phage anti-CRISPR control by an RNA- and DNA-binding helix-turn-helix protein.
Nils Birkholz, Kotaro Kamata, Maximilian Feussner, Max E Wilkinson, Christian Cuba Samaniego, Chase L Beisel

Nature· July 2024

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TracrRNA reprogramming enables direct PAM-independent detection of RNA with diverse DNA-targeting Cas12 nucleases.
Chunlei Jiao, Natalia L Peeck, Jiaqi Yu, Mohammad Ghaem Maghami, Sarah Kono, Chase L Beisel

Nat Commun· July 2024

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Systematic interrogation of CRISPR antimicrobials in Klebsiella pneumoniae reveals nuclease-, guide- and strain-dependent features influencing antimicrobial activity.
Elena Vialetto, Solange Miele, Moran G Goren, Jiaqi Yu, Yanying Yu, Chase L Beisel

Nucleic Acids Res· June 2024

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Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans.
Fabienne Benz, Sarah Camara-Wilpert, Jakob Russel, Katharina G Wandera, Rimvydė Čepaitė, Chase L Beisel

Cell Host Microbe· June 2024

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A Hitchhiker's guide to CRISPR editing tools in bacteria : CRISPR can help unlock the bacterial world, but technical and regulatory barriers persist.
Nicolas Krink, Pablo Iván Nikel, Chase L Beisel

EMBO Rep· April 2024

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Expanding the flexibility of base editing for high-throughput genetic screens in bacteria.
Sandra Gawlitt, Scott P Collins, Yanying Yu, Samuel A Blackman, Lars Barquist, Chase L Beisel

Nucleic Acids Res· April 2024

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An adapted method for Cas9-mediated editing reveals the species-specific role of β-glucoside utilization driving competition between species.
Éva D H Almási, Nele Knischewski, Lisa Osbelt, Uthayakumar Muthukumarasamy, Youssef El Mouali, Chase L Beisel

J Bacteriol· March 2024

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CRISPR-based screening of small RNA modulators of bile susceptibility in .
Gianluca Prezza, Chunyu Liao, Sarah Reichardt, Chase L Beisel, Alexander J Westermann

Proc Natl Acad Sci U S A· February 2024

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Interrogating two extensively self-targeting Type I CRISPR-Cas systems in Xanthomonas albilineans reveals distinct anti-CRISPR proteins that block DNA degradation.
Franziska Wimmer, Frank Englert, Katharina G Wandera, Omer S Alkhnbashi, Scott P Collins, Chase L Beisel

Nucleic Acids Res· January 2024

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Improved prediction of bacterial CRISPRi guide efficiency from depletion screens through mixed-effect machine learning and data integration.
Yanying Yu, Sandra Gawlitt, Lisa Barros de Andrade E Sousa, Erinc Merdivan, Marie Piraud, Chase L Beisel

Genome Biol· January 2024

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