Publications by authors named "Cheng-Kui Qu"

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Two genes, one culprit - a functional candidate validation of a SPATA7 deletion in dogs with day blindness/retinal degeneration.
Leonardo Murgiano, Jessica K Niggel, Kei Takahashi, Valérie L Dufour, Catharina R Grubaugh, Cheng-Kui Qu

PLoS Genet· December 2025

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Non-canonical dihydrolipoyl transacetylase promotes chemotherapy resistance via mitochondrial tetrahydrofolate signaling.
Jung Seok Hwang, JiHoon Kang, Jaehyun Kim, Kiyoung Eun, Sophia West, Cheng-Kui Qu

Nat Commun· October 2025

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Innate immune mechanisms hijacked by leukemia-initiating stem cells for selective advantage and immune evasion in Ptpn11-associated JMML.
Hong Zheng, Peng Zhao, Zhenya Tan, Wen-Mei Yu, Juwita Werner, Cheng-Kui Qu

Cell Rep· August 2025

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PRMT1-mediated metabolic reprogramming promotes leukemogenesis.
Hairui Su, Yong Sun, Han Guo, Chiao-Wang Sun, Qiuying Chen, Cheng-Kui Qu

Elife· August 2025

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Biomedical engineering and interdisciplinary research in shaping tomorrow's medicine.
Angela Chen, Carly Harris, Cheng-Kui Qu

iScience· July 2025

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Enhanced engraftment of human haematopoietic stem cells via mechanical remodelling mediated by the corticotropin-releasing hormone.
Mingming Wu, Haoxiang Yang, Senquan Liu, Lai Jiang, Tingting Liang, Cheng-Kui Qu

Nat Biomed Eng· May 2025

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Prototypical innate immune mechanism hijacked by leukemia-initiating mutant stem cells for selective advantage and immune evasion in Ptpn11-associated juvenile myelomonocytic leukemia.
Hong Zheng, Peng Zhao, Zhenya Tan, Wen-Mei Yu, Juwita Werner, Cheng-Kui Qu

Res Sq· August 2024

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SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis.
Surbhi Chouhan, Dhivya Sridaran, Cody Weimholt, Jingqin Luo, Tiandao Li, Cheng-Kui Qu

Nat Commun· July 2024

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Mitochondrial metabolic flexibility is critical for CD8 T cell antitumor immunity.
Chao Chen, Hong Zheng, Edwin M Horwitz, Satomi Ando, Koichi Araki, Cheng-Kui Qu

Sci Adv· December 2023

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AMPK activator-treated human cardiac spheres enhance maturation and enable pathological modeling.
Dong Li, Lawrence C Armand, Fangxu Sun, Hyun Hwang, David Wolfson, Cheng-Kui Qu

Stem Cell Res Ther· November 2023

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Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice.
Hong Zheng, Qianjin Li, Shanhu Li, Zhiguo Li, Marco Brotto, Cheng-Kui Qu

Elife· September 2023

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Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis.
Yuhan Yan, Chao Chen, Zhiguo Li, Jing Zhang, Narin Park, Cheng-Kui Qu

Sci Rep· December 2022

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Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells.
Rukang Zhang, Dong Chen, Hao Fan, Rong Wu, Jiayi Tu, Cheng-Kui Qu

Cell Chem Biol· July 2022

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JMML tumor cells disrupt normal hematopoietic stem cells by imposing inflammatory stress through overproduction of IL-1β.
Yuhan Yan, Lei Dong, Chao Chen, Kevin D Bunting, Qianjin Li, Cheng-Kui Qu

Blood Adv· January 2022

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Methylation of dual-specificity phosphatase 4 controls cell differentiation.
Hairui Su, Ming Jiang, Chamara Senevirathne, Srinivas Aluri, Tuo Zhang, Cheng-Kui Qu

Cell Rep· July 2021

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Decreased cell stiffness enhances leukemia development and progression.
Linping Hu, Fang Ni, Xinyi Wang, Meredith E Fay, Katherine M Young, Cheng-Kui Qu

Leukemia· September 2020

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Germline mutations: many roles in leukemogenesis.
Kevin Z Chen, Rafi Kazi, Christopher C Porter, Cheng-Kui Qu

Curr Opin Hematol· July 2020

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Targeting HIF-1α in combination with PPARα activation and postnatal factors promotes the metabolic maturation of human induced pluripotent stem cell-derived cardiomyocytes.
Cinsley Gentillon, Dong Li, Meixue Duan, Wen-Mei Yu, Marcela K Preininger, Cheng-Kui Qu

J Mol Cell Cardiol· July 2019

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Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
Fang Ni, Wen-Mei Yu, Xinyi Wang, Meredith E Fay, Katherine M Young, Cheng-Kui Qu

Cell Stem Cell· April 2019

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Critical role of ASCT2-mediated amino acid metabolism in promoting leukaemia development and progression.
Fang Ni, Wen-Mei Yu, Zhiguo Li, Douglas K Graham, Lingtao Jin, Cheng-Kui Qu

Nat Metab· March 2019

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Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2.
Xiaoqin Wu, Gang Xu, Xiaobo Li, Weiren Xu, Qianjin Li, Cheng-Kui Qu

J Med Chem· February 2019

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The tyrosine phosphatase Shp-2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration.
Jessica Gagné-Sansfacon, Ariane Langlois, Marie-Josée Langlois, Geneviève Coulombe, Sarah Tremblay, Cheng-Kui Qu

J Pathol· January 2019

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Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.
Yoshihiro Hayashi, Yue Zhang, Asumi Yokota, Xiaomei Yan, Jinqin Liu, Cheng-Kui Qu

Cancer Discov· November 2018

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Germline mutations in the bone marrow microenvironment and dysregulated hematopoiesis.
Lane H Miller, Cheng-Kui Qu, Melinda Pauly

Exp Hematol· October 2018

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Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development.
Hong Zheng, Wen-Mei Yu, Jinhua Shen, Sumin Kang, Dolores Hambardzumyan, Cheng-Kui Qu

Sci Adv· October 2018

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