Publications by authors named "Chengkui Yang"

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Discovery of Zharp1-163 as a dual inhibitor of ferroptosis and necroptosis for the treatment of inflammatory disorders and kidney injury.
Yuting Ji, Shujing Du, Jingjing Li, Haikuo Ma, Xinhui Wang, Chengkui Yang

Cell Death Discov· August 2025

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Inhibition of lysosome-tethered Ragulator-Rag-3D complex restricts the replication of Enterovirus 71 and Coxsackie A16.
Xinhui Wang, Zhilin Hu, Wei Zhang, Shuwei Wu, Yongjin Hao, Chengkui Yang

J Cell Biol· December 2023

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Discovery of a novel RIPK2 inhibitor for the treatment of inflammatory bowel disease.
Yujun Lai, Xinhui Wang, Xue Sun, Shuwei Wu, Xin Chen, Chengkui Yang

Biochem Pharmacol· August 2023

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A novel RIPK1 inhibitor reduces GVHD in mice via a nonimmunosuppressive mechanism that restores intestinal homeostasis.
Xiaoliang Yu, Haikuo Ma, Bohan Li, Yuting Ji, Yayun Du, Chengkui Yang, Tao Yang

Blood· March 2023

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Discovery, optimization and evaluation of isothiazolo[5,4-b]pyridine derivatives as RIPK1 inhibitors with potent in vivo anti-SIRS activity.
Yongjin Hao, Chengkui Yang, Chang Shu, Zhanhui Li, Kaijiang Xia

Bioorg Chem· December 2022

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Interferon-mediated repression of miR-324-5p potentiates necroptosis to facilitate antiviral defense.
Xiaoyan Dou, Xiaoliang Yu, Shujing Du, Yu Han, Liang Li, Tao Yang, Chengkui Yang

EMBO Rep· August 2022

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Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity.
Zhanhui Li, Yongjin Hao, Chengkui Yang, Qing Yang, Shuwei Wu, Tao Yang

Eur J Med Chem· January 2022

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Discovery of a Potent RIPK3 Inhibitor for the Amelioration of Necroptosis-Associated Inflammatory Injury.
Kaijiang Xia, Fang Zhu, Chengkui Yang, Shuwei Wu, Yu Lin, Tao Yang

Front Cell Dev Biol· December 2020

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Endothelial Overexpression of Metallothionein Prevents Diabetes-Induced Impairment in Ischemia Angiogenesis Through Preservation of HIF-1α/SDF-1/VEGF Signaling in Endothelial Progenitor Cells.
Kai Wang, Xiaozhen Dai, Junhong He, Xiaoqing Yan, Chengkui Yang

Diabetes· August 2020

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Doxorubicin sensitizes cancer cells to Smac mimetic via synergistic activation of the CYLD/RIPK1/FADD/caspase-8-dependent apoptosis.
Chengkui Yang, Qiao Ran, Yifei Zhou, Shan Liu, Cong Zhao, Tao Yang

Apoptosis· June 2020

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Regulation of RIP3 by the transcription factor Sp1 and the epigenetic regulator UHRF1 modulates cancer cell necroptosis.
Chengkui Yang, Jun Li, Lu Yu, Zili Zhang, Feng Xu

Cell Death Dis· October 2017

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Aqueous synthesized quantum dots interfere with the NF-κB pathway and confer anti-tumor, anti-viral and anti-inflammatory effects.
Zhilin Hu, Bin Song, Lei Xu, Yiling Zhong, Fei Peng, Chengkui Yang

Biomaterials· November 2016

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Correction: Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
Kai Liu, Youli Jian, Xiaojuan Sun, Chengkui Yang, Zhiyang Gao, Yang Li, Chonglin Yang

J Cell Biol· March 2016

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Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1.
Xiaoliang Yu, Yun Li, Qin Chen, Chenhe Su, Zili Zhang, Chengkui Yang

J Virol· January 2016

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Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
Kai Liu, Youli Jian, Xiaojuan Sun, Chengkui Yang, Zhiyang Gao, Yang Li, Chonglin Yang

J Cell Biol· January 2016

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