Publications by authors named "Chenglai Fu"

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Astrocyte-Specific Nrf2 Expression Transforms Neurotoxic Reactive Astrocytes to Neuroprotective Phenotype in 3xTg-AD Mice.
Shenrui Guo, Feng Wei, Hui Sun, Hongfu Jin, Weiwei Cheng, Chenglai Fu, Yafu Yin

Glia· January 2026

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Identification of key genes associated with atrial fibrillation and hypoxia using WGCNA and machine learning technology.
Chao Wang, Mardan Muradil, Jianbin Huang, Jie Cai, Fangbao Ding, Chenglai Fu

Front Cardiovasc Med· December 2025

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C9orf72 related poly-Glycine-Alanine promotes tau phosphorylation and cell death via ERK1/2 interaction in cellular models.
Jiahan Zhuang, Zixuan Zhang, Hongfu Jin, Ji Qi, Yuanyuan Chen, Chenglai Fu

Neuroscience· November 2025

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Inositol pyrophosphate kinases in health and disease.
Changchang Xing, Chao Wang, Yuanyuan Chen, Weiwei Cheng, Zhaolei Jiang, Chenglai Fu

FEBS Lett· October 2025

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Restoring glucose metabolism in Alzheimer's disease by targeting integrated stress response.
Hui Sun, Shenrui Guo, Hongfu Jin, Lin Ding, Yuanyuan Chen, Chenglai Fu, Yafu Yin

Neurotherapeutics· September 2025

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Early astrocyte-targeted intervention guided by F-SMBT-1 imaging attenuates disease progression in 3xTg-AD mice.
Shenrui Guo, Feng Wei, Yuge Chang, Shuqi Wu, Zhiyin Lou, Chenglai Fu, Yafu Yin

Eur J Nucl Med Mol Imaging· September 2025

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F-Fluorodeoxyglucose positron emission tomography/computed tomography in distinguishing pediatric clear cell sarcoma of the kidney from Wilms' tumor.
Hui Sun, Zhiyong Yang, Hongfu Jin, Yanfen Cui, Yafu Yin, Chenglai Fu

Pediatr Radiol· May 2025

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IP6K1 Rewires LKB1 Signaling to Mediate Hyperglycemic Endothelial Senescence.
Changchang Xing, Linhui Shi, Limei Zhu, Tim Aguirre, Ji Qi, Chenglai Fu

Diabetes· April 2025

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Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I.
Xiaoqi Liu, Zixuan Zhang, Tim Aguirre, Megan L Shipton, Lin Fu, David Furkert, Chenglai Fu

Metabolism· February 2025

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Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin.
Lin Fu, Jimin Du, David Furkert, Megan L Shipton, Xiaoqi Liu, Chenglai Fu

Cardiovasc Res· July 2024

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Metformin ameliorates mitochondrial damage induced by C9orf72 poly(GR) via upregulating AKT phosphorylation.
Yiyuan Feng, Zhongyun Xu, Hongfu Jin, Yuanyuan Chen, Chenglai Fu, Yafu Yin

J Cell Biochem· March 2024

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Functions, Mechanisms, and therapeutic applications of the inositol pyrophosphates 5PP-InsP and InsP in mammalian cells.
Ji Qi, Linhui Shi, Limei Zhu, Yuanyuan Chen, Hong Zhu, Chenglai Fu

J Cardiovasc Transl Res· February 2024

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Deleting IP6K1 stabilizes neuronal sodium-potassium pumps and suppresses excitability.
Hongfu Jin, Aili Liu, Alfred C Chin, Chenglai Fu, Hui Shen

Mol Brain· February 2024

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Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling.
Ji Qi, Weiwei Cheng, Zhe Gao, Yuanyuan Chen, Megan L Shipton, David Furkert, Chenglai Fu

Biomed Pharmacother· May 2023

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The inositol pyrophosphate 5-InsP drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85α.
Alfred C Chin, Zhe Gao, Andrew M Riley, David Furkert, Christopher Wittwer, Chenglai Fu

Sci Adv· October 2020

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Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2.
Feng Rao, Jiyoung Cha, Jing Xu, Risheng Xu, M Scott Vandiver, Chenglai Fu

Mol Cell· August 2020

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IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration.
Prasun Guha, Richa Tyagi, Sayan Chowdhury, Luke Reilly, Chenglai Fu

Cell Rep· March 2019

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Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover via interactions with dynein intermediate chain 2.
Tomas Rojas, Weiwei Cheng, Zhe Gao, Xiaoqi Liu, Yakun Wang, Chenglai Fu

Proc Natl Acad Sci U S A· February 2019

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Inositol Hexakisphosphate Kinase-2 in Cerebellar Granule Cells Regulates Purkinje Cells and Motor Coordination via Protein 4.1N.
Latika Nagpal, Chenglai Fu, Solomon H Snyder

J Neurosci· August 2018

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Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1.
Chenglai Fu, Tomas Rojas, Alfred C Chin, Weiwei Cheng, Isaac A Bernstein

Sci Rep· May 2018

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Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation.
Chenglai Fu, Richa Tyagi, Alfred C Chin, Tomas Rojas, Ruo-Jing Li

Circ Res· February 2018

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C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation.
Weiwei Cheng, Shaopeng Wang, Alexander A Mestre, Chenglai Fu, Andres Makarem

Nat Commun· January 2018

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Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.
Chenglai Fu, Jing Xu, Weiwei Cheng, Tomas Rojas, Alfred C Chin

Proc Natl Acad Sci U S A· February 2017

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Regulation of mTORC1 by lysosomal calcium and calmodulin.
Ruo-Jing Li, Jing Xu, Chenglai Fu, Jing Zhang, Yujun George Zheng

Elife· October 2016

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Inositol Hexakisphosphate Kinase-3 Regulates the Morphology and Synapse Formation of Cerebellar Purkinje Cells via Spectrin/Adducin.
Chenglai Fu, Jing Xu, Ruo-Jing Li, Joshua A Crawford, A Basit Khan

J Neurosci· August 2015

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