Publications by authors named "Chester Brown"

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Clinical utility and cost-effectiveness of BeginNGS newborn screening by genome sequencing and standard newborn screening for severe childhood genetic diseases: an adaptive, international and comparative clinical trial.
Rebecca Reimers, Miranda Bailey, Chester Brown, Kee Chan, Tom Defay

BMJ Open· November 2025

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Multiple molecular diagnoses identified through genome sequencing in individuals with suspected rare disease.
Alka Malhotra, Erin Thorpe, Alison J Coffey, Revathi Rajkumar, Josephine Adjeman, Chester Brown

HGG Adv· July 2025

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Insights from the Biorepository and Integrative Genomics pediatric resource.
Silvia Buonaiuto, Franco Marsico, Akram Mohammed, Lokesh K Chinthala, Ernestine K Amos-Abanyie, Chester W Brown

Nat Commun· May 2025

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The Biorepository and Integrative Genomics resource for inclusive genomics: insights from a diverse pediatric and admixed cohort.
Silvia Buonaiuto, Franco Marsico, Akram Mohammed, Lokesh K Chinthala, Ernestine K Amos-Abanyie, Chester W Brown

medRxiv· February 2025

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The impact of clinical genome sequencing in a global population with suspected rare genetic disease.
Erin Thorpe, Taylor Williams, Chad Shaw, Evgenii Chekalin, Julia Ortega, Chester W Brown

Am J Hum Genet· July 2024

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Long-term non-progression and risk factors for disease progression among children living with HIV in Botswana and Uganda: A retrospective cohort study.
Samuel Kyobe, Grace Kisitu, Savannah Mwesigwa, John Farirai, Eric Katagirya, Chester Brown

Int J Infect Dis· February 2024

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An Overview of UBTF Neuroregression Syndrome.
Anneliesse A Braden, Jianfeng Xiao, Roderick Hori, Chester Brown, Mohammad Moshahid Khan

Brain Sci· February 2024

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Exogenous mitochondrial transfer increases energy expenditure and attenuates adiposity gains in mice with diet-induced obesity.
Maria Namwanje, Soumi Mazumdar, Amanda Stayton, Prisha S Patel, Christine Watkins, Chester Brown

bioRxiv· December 2023

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Effect of Whole-Genome Sequencing on the Clinical Management of Acutely Ill Infants With Suspected Genetic Disease: A Randomized Clinical Trial.

JAMA Pediatr· December 2021

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SMAD2 and SMAD3 differentially regulate adiposity and the growth of subcutaneous white adipose tissue.
Roshan Kumari, Maria Johnson Irudayam, Qusai Al Abdallah, Tamekia L Jones, Tahliyah S Mims, Chester W Brown

FASEB J· December 2021

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Case Report: An Infant With Kabuki Syndrome, Alobar Holoprosencephaly and Truncus Arteriosus: A Case for Whole Exome Sequencing in Neonates With Congenital Anomalies.
Rishika P Sakaria, Parul G Zaveri, Shannon Holtrop, Jie Zhang, Chester W Brown

Front Genet· November 2021

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Exome Sequencing Reveals a Putative Role for HLA-C*03:02 in Control of HIV-1 in African Pediatric Populations.
Samuel Kyobe, Savannah Mwesigwa, Grace P Kisitu, John Farirai, Eric Katagirya, Chester W Brown

Front Genet· August 2021

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Unmapped exome reads implicate a role for Anelloviridae in childhood HIV-1 long-term non-progression.
Savannah Mwesigwa, Lesedi Williams, Gaone Retshabile, Eric Katagirya, Gerald Mboowa, Chester W Brown

NPJ Genom Med· March 2021

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Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3.
Jessica A Hall, Deepti Ramachandran, Hyun C Roh, Joanna R DiSpirito, Thiago Belchior, Chester W Brown

Cell Metab· October 2020

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Further delineation of the clinical spectrum of KAT6B disorders and allelic series of pathogenic variants.
Li Xin Zhang, Gabrielle Lemire, Claudia Gonzaga-Jauregui, Sirinart Molidperee, Carolina Galaz-Montoya, Chester Brown

Genet Med· August 2020

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Phenotypic expansion of POGZ-related intellectual disability syndrome (White-Sutton syndrome).
Nurit Assia Batzir, Jennifer E Posey, Xiaofei Song, Zeynep Coban Akdemir, Jill A Rosenfeld, Chester W Brown

Am J Med Genet A· January 2020

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Spatially clustering de novo variants in CYFIP2, encoding the cytoplasmic FMRP interacting protein 2, cause intellectual disability and seizures.
Markus Zweier, Anaïs Begemann, Kirsty McWalter, Megan T Cho, Lucia Abela, Chester W Brown

Eur J Hum Genet· May 2019

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Complex Compound Inheritance of Lethal Lung Developmental Disorders Due to Disruption of the TBX-FGF Pathway.
Justyna A Karolak, Marie Vincent, Gail Deutsch, Tomasz Gambin, Benjamin Cogné, Chester W Brown

Am J Hum Genet· February 2019

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Standardizing return of participant results.
Jeffrey R Botkin, Paul S Appelbaum, Suzanne Bakken, Chester Brown, Wylie Burke

Science· November 2018

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Insulin Regulates Lipolysis and Fat Mass by Upregulating Growth/Differentiation Factor 3 in Adipose Tissue Macrophages.
Yun Bu, Katsuhide Okunishi, Satomi Yogosawa, Kouichi Mizuno, Maria Johnson Irudayam, Chester W Brown

Diabetes· September 2018

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De Novo Missense Variants in TRAF7 Cause Developmental Delay, Congenital Anomalies, and Dysmorphic Features.
Mari J Tokita, Chun-An Chen, David Chitayat, Ellen Macnamara, Jill A Rosenfeld, Chester W Brown

Am J Hum Genet· July 2018

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Correction: Combinatorial actions of Tgfβ and Activin ligands promote oligodendrocyte development and CNS myelination (doi:10.1242/dev.106492).
Dipankar J Dutta, Andleeb Zameer, John N Mariani, Jingya Zhang, Linnea Asp, Chester W Brown

Development· July 2018

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The Collaborative African Genomics Network (CAfGEN): Applying Genomic technologies to probe host factors important to the progression of HIV and HIV-tuberculosis infection in sub-Saharan Africa.
Gerald Mboowa, Savannah Mwesigwa, Eric Katagirya, Gaone Retshabile, Busisiwe C Mlotshwa, Chester W Brown

AAS Open Res· June 2018

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Whole-Exome Sequencing Reveals Uncaptured Variation and Distinct Ancestry in the Southern African Population of Botswana.
Gaone Retshabile, Busisiwe C Mlotshwa, Lesedi Williams, Savannah Mwesigwa, Gerald Mboowa, Chester W Brown

Am J Hum Genet· May 2018

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Use of Exome Sequencing for Infants in Intensive Care Units: Ascertainment of Severe Single-Gene Disorders and Effect on Medical Management.
Linyan Meng, Mohan Pammi, Anirudh Saronwala, Pilar Magoulas, Andrew Ray Ghazi, Chester Brown

JAMA Pediatr· December 2017

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