Publications by authors named "Ching-Hsein Chen"

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miRNAs as potential biomarkers for early detection of prediabetes among obesity: a systematic review.
Brenda Wen Keng-Lim, Kelvin Yee Chen-Ng, Jia Yee-Lee, Ching Hsein-Chen, Wan Ling-Chang

Biosci Rep· December 2025

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Shikonin as a Dietary Phytochemical with Multi-Target Anti-Cancer Activities: From Molecular Mechanisms to Translational Applications.
Chun-Yik Lew, Yi-Teng Tang, Amanda Yee-Jing Lee, Zhi-Jian Chin, Wan-Ling Chang, Ching-Hsein Chen

Nutrients· September 2025

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Piperine Induces Apoptosis and Cell Cycle Arrest via Multiple Oxidative Stress Mechanisms and Regulation of PI3K/Akt and MAPK Signaling in Colorectal Cancer Cells.
Wan-Ling Chang, Jyun-Yu Peng, Chain-Lang Hong, Pei-Ching Li, Soi Moi Chye, Ching-Hsein Chen

Antioxidants (Basel)· July 2025

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Virus-like Particles-Based Vaccine to Combat Neurodegenerative Diseases.
Luis Wei Cheng Lim, Jia Yee Lee, Ching Hsein Chen, Kenny Gah Leong Voon, Rhun Yian Koh

Curr Pharm Biotechnol· October 2024

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Parecoxib Enhances Resveratrol against Human Colorectal Cancer Cells through Akt and TXNDC5 Inhibition and MAPK Regulation.
Wan-Ling Chang, Kai-Chien Yang, Jyun-Yu Peng, Chain-Lang Hong, Pei-Ching Li, Ching-Hsein Chen

Nutrients· September 2024

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Parecoxib and 5-Fluorouracil Synergistically Inhibit EMT and Subsequent Metastasis in Colorectal Cancer by Targeting PI3K/Akt/NF-κB Signaling.
Wan-Ling Chang, Jyun-Yu Peng, Chain-Lang Hong, Pei-Ching Li, Fung-Jou Lu, Ching-Hsein Chen

Biomedicines· July 2024

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Parecoxib expresses anti-metastasis effect through inhibition of epithelial-mesenchymal transition and the Wnt/β-catenin signaling pathway in human colon cancer DLD-1 cell line.
Chung Hang Wong, Wan-Ling Chang, Fung-Jou Lu, Yi-Wen Liu, Jyun-Yu Peng, Ching-Hsein Chen

Environ Toxicol· November 2022

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Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF-B Pathway.
Jen-Tsung Yang, I-Neng Lee, Fung-Jou Lu, Chiu-Yen Chung, Ming-Hsueh Lee, Yu-Ching Cheng, Kuo-Tai Chen, Ching-Hsein Chen

J Immunol Res· July 2018

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Anti-angiogenic effect of hexahydrocurcumin in rat corneal neovascularization.
Chien-Neng Kuo, Ching-Hsein Chen, San-Ni Chen, Jou-Cheng Huang, Li-Ju Lai, Chung-Yi Chen

Int Ophthalmol· April 2018

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Yellow and green pigments from L. seed oil induce cell death in colon and lung cancer cells.
Chiawen Hsieh, Yun-Wei Lin, Ching-Hsein Chen, Wenjun Ku, Fuching Ma

Oncol Lett· April 2018

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The interaction of arsenic and N-butyl-N-(4-hydroxybutyl)nitrosamine on urothelial carcinogenesis in mice.
Yuan-Chang Dai, Shou-Chieh Wang, Mohammad Mezbahul Haque, Wei-Han Lin, Lei-Chen Lin, Ching-Hsein Chen

PLoS One· October 2017

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Anti-oxidative Responses on Hepatic Tissue of Zebrafish (Danio rerio) in a Short Duration of Sub-lethal Concentrations of Cadmium Exposure.
Su Mei Wu, Li-Hsin Shu, Jia-Hao Liu, Ching Hsein Chen

Bull Environ Contam Toxicol· May 2017

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Folate Deficiency Triggered Apoptosis of Synoviocytes: Role of Overproduction of Reactive Oxygen Species Generated via NADPH Oxidase/Mitochondrial Complex II and Calcium Perturbation.
Hung-Chih Hsu, Wen-Ming Chang, Jin-Yi Wu, Chin-Chin Huang, Fung-Jou Lu, Kai-Hua Chen, Ching-Hsein Chen

PLoS One· July 2016

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Synergistic antioxidant activity of resveratrol with genistein in high-glucose treated Madin-Darby canine kidney epithelial cells.
Chishih Chu, Fung-Jou Lu, Rang-Hui Yeh, Zih-Ling Li, Ching-Hsein Chen

Biomed Rep· March 2016

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Anti-oxidative responses of zebrafish (Danio rerio) gill, liver and brain tissues upon acute cold shock.
Su Mei Wu, Jia-Hao Liu, Li-Hsin Shu, Ching Hsein Chen

Comp Biochem Physiol A Mol Integr Physiol· September 2015

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An oxidative stress mechanism of shikonin in human glioma cells.
Jen-Tsung Yang, Zih-Ling Li, Jin-Yi Wu, Fung-Jou Lu, Ching-Hsein Chen

PLoS One· December 2014

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Folate deficiency triggers an oxidative-nitrosative stress-mediated apoptotic cell death and impedes insulin biosynthesis in RINm5F pancreatic islet β-cells: relevant to the pathogenesis of diabetes.
Hung-Chih Hsu, Jeng-Fong Chiou, Yu-Huei Wang, Chia-Hui Chen, Shin-Yi Mau, Ching-Hsein Chen

PLoS One· August 2014

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Shikonin suppresses the migratory ability of hepatocellular carcinoma cells.
Po-Li Wei, Chao-Chiang Tu, Ching-Hsein Chen, Yuan-Soon Ho, Chun-Te Wu, Wei-Yu Chen

J Agric Food Chem· August 2013

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Inhibition of corneal neovascularization with the combination of bevacizumab and plasmid pigment epithelium-derived factor-synthetic amphiphile INTeraction-18 (p-PEDF-SAINT-18) vector in a rat corneal experimental angiogenesis model.
Chien-Neng Kuo, Chung-Yi Chen, San-Ni Chen, Lin-Cheng Yang, Li-Ju Lai, Miao-Fen Chen, Ching-Hsein Chen

Int J Mol Sci· April 2013

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Propyl gallate inhibits TPA-induced inflammation via the nuclear factor-κB pathway in human THP-1 monocytes.
Hung-Chih Hsu, Wan-Chen Lin, Pey-Jium Chang, Chang-Zern Hong, Ching-Hsein Chen

Exp Ther Med· March 2013

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GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells.
Yu-Jia Chang, Yi-Ping Huang, Zih-Ling Li, Ching-Hsein Chen

PLoS One· November 2012

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Cell cycle regulation by bevacizumab in ARPE-19 human retinal pigment epithelial cells.
Chien-Neng Kuo, Chung-Yi Chen, Chien-Hsiung Lai, Li-Ju Lai, Pei-Chen Wu, Ching-Hsein Chen

Mol Med Rep· October 2012

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Novel multiple apoptotic mechanism of shikonin in human glioma cells.
Ching-Hsein Chen, Miao-Ling Lin, Ping-Lin Ong, Jen-Tsung Yang

Ann Surg Oncol· September 2012

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Anti-Cancer Effects of Protein Extracts from Calvatia lilacina, Pleurotus ostreatus and Volvariella volvacea.
Jin-Yi Wu, Chi-Hung Chen, Wen-Huei Chang, King-Thom Chung, Yi-Wen Liu, Ching-Hsein Chen

Evid Based Complement Alternat Med· November 2011

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Enhancement of temozolomide-induced apoptosis by valproic acid in human glioma cell lines through redox regulation.
Ching-Hsein Chen, Yu-Jia Chang, Maurice S B Ku, King-Thom Chung, Jen-Tsung Yang

J Mol Med (Berl)· March 2011

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