Publications by authors named "Chris Chumsae"

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Integrated SegFlow, µSIA, and UPLC for Online Sialic Acid Quantitation of Glycoproteins Directly from Bioreactors.
Letha Chemmalil, Tanmay Kulkarni, Mathura Raman, Priya Singh, Yueming Qian, Chris Chumsae

Eng Life Sci· January 2025

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Attribute Analytics Performance Metrics from the MAM Consortium Interlaboratory Study.
Trina Mouchahoir, John E Schiel, Rich Rogers, Alan Heckert, Benjamin J Place, Chris M Chumsae

J Am Soc Mass Spectrom· September 2022

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Global intercompany assessment of ICIEF platform comparability for the characterization of therapeutic proteins.
Seth Madren, Will McElroy, Kristin Schultz-Kuszak, Boris Boumajny, Yao Shu, Chris Chumsae

Electrophoresis· May 2022

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New Peak Detection Performance Metrics from the MAM Consortium Interlaboratory Study.
Trina Mouchahoir, John E Schiel, Rich Rogers, Alan Heckert, Benjamin J Place, Chris M Chumsae

J Am Soc Mass Spectrom· April 2021

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PULSE SPR: A High Throughput Method to Evaluate the Domain Stability of Antibodies.
Li Zhou, Jun Zhang, Enrico DiGiammarino, Amol Kavishwar, Bo Yan, Chris Chumsae

Anal Chem· October 2018

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Detection of Alkynes via Click Chemistry with a Brominated Coumarin Azide by Simultaneous Fluorescence and Isotopic Signatures in Mass Spectrometry.
Lihua Yang, Chris Chumsae, Jenifer B Kaplan, Kevin Ryan Moulton, Dongdong Wang

Bioconjug Chem· September 2017

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When Good Intentions Go Awry: Modification of a Recombinant Monoclonal Antibody in Chemically Defined Cell Culture by Xylosone, an Oxidative Product of Ascorbic Acid.
Chris Chumsae, Patrick Hossler, Haly Raharimampionona, Yu Zhou, Sean McDermott

Anal Chem· August 2015

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Comparison of the in vitro and in vivo stability of a succinimide intermediate observed on a therapeutic IgG1 molecule.
David Ouellette, Chris Chumsae, Anca Clabbers, Czeslaw Radziejewski, Ivan Correia

MAbs· April 2015

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Discovery of a chemical modification by citric acid in a recombinant monoclonal antibody.
Chris Chumsae, Liqiang Lisa Zhou, Yang Shen, Jessica Wohlgemuth, Emma Fung

Anal Chem· September 2014

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Expression of antibodies using single open reading frame (sORF) vector design: Demonstration of manufacturing feasibility.
Wendy R Gion, Rachel A Davis-Taber, Dean A Regier, Emma Fung, Limary Medina, Chris M Chumsae

MAbs· January 2014

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Arginine modifications by methylglyoxal: discovery in a recombinant monoclonal antibody and contribution to acidic species.
Chris Chumsae, Kathreen Gifford, Wei Lian, Hongcheng Liu, Czeslaw H Radziejewski

Anal Chem· December 2013

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Quantitation of a recombinant monoclonal antibody in monkey serum by liquid chromatography-mass spectrometry.
Hongcheng Liu, Anton V Manuilov, Chris Chumsae, Michelle L Babineau, Edit Tarcsa

Anal Biochem· July 2011

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Effect of the light chain C-terminal serine residue on disulfide bond susceptibility of human immunoglobulin G1λ.
Hongcheng Liu, Suju Zhong, Chris Chumsae, Czeslaw Radziejewski, Chung-Ming Hsieh

Anal Biochem· January 2011

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Ranking the susceptibility of disulfide bonds in human IgG1 antibodies by reduction, differential alkylation, and LC-MS analysis.
Hongcheng Liu, Chris Chumsae, Georgeen Gaza-Bulseco, Karen Hurkmans, Czeslaw H Radziejewski

Anal Chem· June 2010

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Domain-level stability of an antibody monitored by reduction, differential alkylation, and mass spectrometry analysis.
Hongcheng Liu, Chris Chumsae, Georgeen Gaza-Bulseco, Eric R Goedken

Anal Biochem· May 2010

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Analysis of reduced monoclonal antibodies using size exclusion chromatography coupled with mass spectrometry.
Hongcheng Liu, Georgeen Gaza-Bulseco, Chris Chumsae

J Am Soc Mass Spectrom· December 2009

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Localization and quantitation of free sulfhydryl in recombinant monoclonal antibodies by differential labeling with 12C and 13C iodoacetic acid and LC-MS analysis.
Tao Xiang, Chris Chumsae, Hongcheng Liu

Anal Chem· October 2009

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Identification and localization of unpaired cysteine residues in monoclonal antibodies by fluorescence labeling and mass spectrometry.
Chris Chumsae, Georgeen Gaza-Bulseco, Hongcheng Liu

Anal Chem· August 2009

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Effect of the conserved oligosaccharides of recombinant monoclonal antibodies on the separation by protein A and protein G chromatography.
Georgeen Gaza-Bulseco, Keith Hickman, Sara Sinicropi-Yao, Karen Hurkmans, Chris Chumsae

J Chromatogr A· March 2009

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Glutamine deamidation of a recombinant monoclonal antibody.
Hongcheng Liu, Georgeen Gaza-Bulseco, Chris Chumsae

Rapid Commun Mass Spectrom· December 2008

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Heterogeneity of monoclonal antibodies.
Hongcheng Liu, Georgeen Gaza-Bulseco, Dinesh Faldu, Chris Chumsae, Joanne Sun

J Pharm Sci· July 2008

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Effect of methionine oxidation of a recombinant monoclonal antibody on the binding affinity to protein A and protein G.
Georgeen Gaza-Bulseco, Sagar Faldu, Karen Hurkmans, Chris Chumsae, Hongcheng Liu

J Chromatogr B Analyt Technol Biomed Life Sci· July 2008

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Structural effect of deglycosylation and methionine oxidation on a recombinant monoclonal antibody.
Hongcheng Liu, Georgeen Gaza-Bulseco, Tao Xiang, Chris Chumsae

Mol Immunol· February 2008

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Mass spectrometry analysis of in vitro nitration of a recombinant human IgG1 monoclonal antibody.
Hongcheng Liu, Georgeen Gaza-Bulseco, Chris Chumsae, Czeslaw H Radziejewski

Rapid Commun Mass Spectrom· February 2008

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Characterization of the glycosylation state of a recombinant monoclonal antibody using weak cation exchange chromatography and mass spectrometry.
Georgeen Gaza-Bulseco, Ashley Bulseco, Chris Chumsae, Hongcheng Liu

J Chromatogr B Analyt Technol Biomed Life Sci· February 2008

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