Publications by authors named "Christian D Young"

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Identifying Pathogenic Contributors of Radiodermatitis Ameliorated by Smad7-Based Targeting in Canine and Mouse Models.
Yao Ke, Mary-Keara Boss, Braden Burdekin, Ben-Zheng Li, Li Bian, Christian D Young

Int J Radiat Oncol Biol Phys· November 2025

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Activation of PI3K and deletion of p53 in keratin 15-expressing mouse mammary cells induces tumor heterogeneity and plasticity modeling metaplastic breast cancer.
Khoa A Nguyen, Lauren E McLemore, Yao Ke, Lisa N DePledge, Lynelle P Smith, Christian D Young

J Pathol· October 2025

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B0092 tumor-bearing mice are a new model for the study of cachexia in head and neck cancer.
Patrick D Livingston, Ana Luiza Labbate Bonaldo, Nicholas A Jamnick, Natalia M Weinzierl, Caleb J Gammon, Christian D Young

Am J Physiol Cell Physiol· August 2025

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MHC class I upregulation contributes to the therapeutic response to radiotherapy in combination with anti-PD-L1/anti-TGF-β in squamous cell carcinomas with enhanced CD8 T cell memory-driven response.
Hanne T Lind, Spencer C Hall, Alexander A Strait, Jack B Goon, John D Aleman, Christian D Young

Cancer Lett· January 2025

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IL-22RA2 Is a SMAD7 Target Mediating the Alleviation of Dermatitis and Psoriatic Phenotypes in Mice.
Yao Ke, Ben-Zheng Li, Khoa Nguyen, Donna Wang, Suyan Wang, Christian D Young

J Invest Dermatol· November 2023

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Polymorphonuclear myeloid-derived suppressor cells and phosphatidylinositol-3 kinase gamma are critical to tobacco-mimicking oral carcinogenesis in mice.
Khoa A Nguyen, Lisa N DePledge, Li Bian, Yao Ke, Von Samedi, Christian D Young

J Immunother Cancer· September 2023

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Inducible nitric oxide synthase (iNOS)-activated Cxcr2 signaling in myeloid cells promotes TGFβ-dependent squamous cell carcinoma lung metastasis.
Xing Li, Yao Ke, Ariel L Hernandez, Jingjing Yu, Li Bian, Christian D Young

Cancer Lett· August 2023

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Revisiting laminin and extracellular matrix remodeling in metastatic squamous cell carcinoma: What have we learned after more than four decades of research?
John D Aleman, Christian D Young, Sana D Karam, Xiao-Jing Wang

Mol Carcinog· January 2023

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Epidermal growth factor receptor signaling in precancerous keratinocytes promotes neighboring head and neck cancer squamous cell carcinoma cancer stem cell-like properties and phosphoinositide 3-kinase inhibitor insensitivity.
Khoa A Nguyen, Madison J Keith, Stephen B Keysar, Spencer C Hall, Anamol Bimali, Christian D Young

Mol Carcinog· July 2022

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Therapeutic Intervention Using a Smad7-Based Tat Protein to Treat Radiation-Induced Oral Mucositis.
Mary-Keara Boss, Yao Ke, Li Bian, Lauren G Harrison, Ber-In Lee, Christian D Young

Int J Radiat Oncol Biol Phys· March 2022

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Distinct immune microenvironment profiles of therapeutic responders emerge in combined TGFβ/PD-L1 blockade-treated squamous cell carcinoma.
Alexander A Strait, Rachel A Woolaver, Spencer C Hall, Christian D Young, Sana D Karam

Commun Biol· August 2021

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Cancer-Associated Fibroblasts Facilitate Squamous Cell Carcinoma Lung Metastasis in Mice by Providing TGFβ-Mediated Cancer Stem Cell Niche.
Xueke Shi, Jingjing Luo, Kelsey J Weigel, Spencer C Hall, Danfeng Du, Christian D Young

Front Cell Dev Biol· August 2021

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Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts.
Xueke Shi, Christian D Young, Hongmei Zhou, Xiaojing Wang

Biomolecules· December 2020

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Cancer Cell CD44 Mediates Macrophage/Monocyte-Driven Regulation of Head and Neck Cancer Stem Cells.
Karina E Gomez, FangLong Wu, Stephen B Keysar, J Jason Morton, Bettina Miller, Christian D Young

Cancer Res· October 2020

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Deletion of p53 and Hyper-Activation of PIK3CA in Keratin-15 Stem Cells Lead to the Development of Spontaneous Squamous Cell Carcinoma.
Samantha M Y Chen, Bian Li, Andrew G Nicklawsky, Alexandra L Krinsky, Tonya Brunetti, Christian D Young

Int J Mol Sci· September 2020

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PARP Inhibition Enhances Radiotherapy of SMAD4-Deficient Human Head and Neck Squamous Cell Carcinomas in Experimental Models.
Ariel L Hernandez, Christian D Young, Li Bian, Kelsey Weigel, Kyle Nolan

Clin Cancer Res· June 2020

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Lessons learned from SMAD4 loss in squamous cell carcinomas.
Ariel L Hernandez, Christian D Young, Jing H Wang, Xiao-Jing Wang

Mol Carcinog· September 2019

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Smad7 Ameliorates TGF-β-Mediated Skin Inflammation and Associated Wound Healing Defects but Not Susceptibility to Experimental Skin Carcinogenesis.
Fulun Li, Li Bian, Shunsuke Iriyama, Zhe Jian, Bin Fan, Christian D Young

J Invest Dermatol· April 2019

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Correction: Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER Breast Cancer.
Luigi Formisano, Kimberly M Stauffer, Christian D Young, Neil E Bhola, Angel L Guerrero-Zotano

Clin Cancer Res· February 2019

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Smad7 Promotes Healing of Radiotherapy-Induced Oral Mucositis without Compromising Oral Cancer Therapy in a Xenograft Mouse Model.
Jingjing Luo, Li Bian, Melanie A Blevins, Dongyan Wang, Chao Liang, Christian D Young

Clin Cancer Res· January 2019

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An ERBB1-3 Neutralizing Antibody Mixture With High Activity Against Drug-Resistant HER2+ Breast Cancers With ERBB Ligand Overexpression.
Luis J Schwarz, Katherine E Hutchinson, Brent N Rexer, Mónica Valeria Estrada, Paula I Gonzalez Ericsson, Christian D Young

J Natl Cancer Inst· November 2017

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Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER Breast Cancer.
Luigi Formisano, Kimberly M Stauffer, Christian D Young, Neil E Bhola, Angel L Guerrero-Zotano

Clin Cancer Res· October 2017

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Genomic profiling of ER breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.
Jennifer M Giltnane, Katherine E Hutchinson, Thomas P Stricker, Luigi Formisano, Christian D Young

Sci Transl Med· August 2017

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Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis.
Meghan Morrison Joly, Michelle M Williams, Donna J Hicks, Bayley Jones, Violeta Sanchez, Christian D Young

Breast Cancer Res· June 2017

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Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancers.
Christian D Young, Carlos L Arteaga, Rebecca S Cook

Breast Cancer Res· December 2015

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