Publications by authors named "Christian Leumann"

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Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in / double deficient X-linked agammaglobulinemia model.
Burcu Bestas, H Yesid Estupiñán, Qing Wang, Shabnam Kharazi, Chenfei He, Christian J Leumann

RSC Chem Biol· May 2025

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The Multiple Challenges of Handling Scientific Integrity in the Swiss Higher Education System.
Christian J Leumann

Chimia (Aarau)· September 2024

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7',5'-alpha-bicyclo-DNA: new chemistry for oligonucleotide exon splicing modulation therapy.
Damien Evéquoz, Ingrid E C Verhaart, Davy van de Vijver, Wolfgang Renner, Annemieke Aartsma-Rus, Christian J Leumann

Nucleic Acids Res· December 2021

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Enzymatic synthesis of biphenyl-DNA oligonucleotides.
Pascal Röthlisberger, Fabienne Levi-Acobas, Christian J Leumann, Marcel Hollenstein

Bioorg Med Chem· June 2020

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Lowering Mutant Huntingtin Using Tricyclo-DNA Antisense Oligonucleotides As a Therapeutic Approach for Huntington's Disease.
Marine Imbert, Florence Blandel, Christian Leumann, Luis Garcia, Aurelie Goyenvalle

Nucleic Acid Ther· October 2019

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Synthesis and Enzymatic Characterization of Sugar-Modified Nucleoside Triphosphate Analogs.
Stella Diafa, Damien Evéquoz, Christian J Leumann, Marcel Hollenstein

Methods Mol Biol· September 2019

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Compatibility of 5-ethynyl-2'F-ANA UTP with in vitro selection for the generation of base-modified, nuclease resistant aptamers.
Fabienne Levi-Acobas, Adam Katolik, Pascal Röthlisberger, Thomas Cokelaer, Ivo Sarac, Christian J Leumann

Org Biomol Chem· September 2019

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NMR solution structure of tricyclo-DNA containing duplexes: insight into enhanced thermal stability and nuclease resistance.
Andrei Istrate, Silke Johannsen, Alena Istrate, Roland K O Sigel, Christian J Leumann

Nucleic Acids Res· May 2019

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Synthesis, biophysical properties, and RNase H activity of 6'-difluoro[4.3.0]bicyclo-DNA.
Sibylle Frei, Adam K Katolik, Christian J Leumann

Beilstein J Org Chem· January 2019

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6'-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations.
Sibylle Frei, Andrei Istrate, Christian J Leumann

Beilstein J Org Chem· December 2018

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Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center.
Jessica Willi, Pascal Küpfer, Damien Evéquoz, Guillermo Fernandez, Assaf Katz, Christian Leumann

Nucleic Acids Res· February 2018

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What Hinders Electron Transfer Dissociation (ETD) of DNA Cations?
Yvonne Hari, Christian J Leumann, Stefan Schürch

J Am Soc Mass Spectrom· December 2017

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Efficacy and Safety Profile of Tricyclo-DNA Antisense Oligonucleotides in Duchenne Muscular Dystrophy Mouse Model.
Karima Relizani, Graziella Griffith, Lucía Echevarría, Faouzi Zarrouki, Patricia Facchinetti, Christian Leumann

Mol Ther Nucleic Acids· September 2017

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2'β-Fluoro-Tricyclo Nucleic Acids (2'F-tc-ANA): Thermal Duplex Stability, Structural Studies, and RNase H Activation.
Alena Istrate, Adam Katolik, Andrei Istrate, Christian J Leumann

Chemistry· August 2017

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Probing the Backbone Topology of DNA: Synthesis and Properties of 7',5'-Bicyclo-DNA.
Damien Evéquoz, Christian J Leumann

Chemistry· June 2017

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Enzymatic Synthesis of 7',5'-Bicyclo-DNA Oligonucleotides.
Stella Diafa, Damien Evéquoz, Christian J Leumann, Marcel Hollenstein

Chem Asian J· June 2017

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Efficient SMN Rescue following Subcutaneous Tricyclo-DNA Antisense Oligonucleotide Treatment.
Valérie Robin, Graziella Griffith, John-Paul L Carter, Christian J Leumann, Luis Garcia

Mol Ther Nucleic Acids· June 2017

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Corrigendum: Modulation of Excess Electron Transfer through LUMO Gradients in DNA Containing Phenanthrenyl Base Surrogates.
Pascal Roethlisberger, Veerabhadrarao Kaliginedi, Christian J Leumann

Chemistry· April 2017

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Modulation of Excess Electron Transfer through LUMO Gradients in DNA Containing Phenanthrenyl Base Surrogates.
Pascal Roethlisberger, Veerabhadrarao Kaliginediand, Christian J Leumann

Chemistry· February 2017

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The Contribution of the Activation Entropy to the Gas-Phase Stability of Modified Nucleic Acid Duplexes.
Yvonne Hari, Branislav Dugovič, Alena Istrate, Annabel Fignolé, Christian J Leumann

J Am Soc Mass Spectrom· July 2016

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Therapeutic Potential of Tricyclo-DNA antisense oligonucleotides.
Aurelie Goyenvalle, Christian Leumann, Luis Garcia

J Neuromuscul Dis· May 2016

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3CAPS - a structural AP-site analogue as a tool to investigate DNA base excision repair.
David Schuermann, Simon P Scheidegger, Alain R Weber, Magnar Bjørås, Christian J Leumann

Nucleic Acids Res· March 2016

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Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides.
Kariem Ezzat, Yoshitsugu Aoki, Taeyoung Koo, Graham McClorey, Leif Benner, Christian Leumann

Nano Lett· July 2015

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The effect of RNA base lesions on mRNA translation.
Alessandro Calabretta, Pascal A Küpfer, Christian J Leumann

Nucleic Acids Res· May 2015

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2'-Fluorination of tricyclo-DNA controls furanose conformation and increases RNA affinity.
Alena Istrate, Michal Medvecky, Christian J Leumann

Org Lett· April 2015

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