Publications by authors named "Christian Werno"

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Micrometastasis-derived models enable drug testing for early-stage, high-risk melanoma patients.
Kathrin Weidele, Christian Werno, Steffi Treitschke, Catherine Botteron, Martin Hoffmann

EMBO Mol Med· December 2025

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Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients.
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Christian Werno

Mol Oncol· July 2025

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MCSP metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization.
Severin Guetter, Courtney König, Huiqin Koerkel-Qu, Aleksandra Markiewicz, Sebastian Scheitler, Christian Werno

Nat Cancer· June 2025

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TheraVision: Engineering platform technology for the development of oncolytic viruses based on herpes simplex virus type 1.
Christina Funk, Nadja Uhlig, Zsolt Ruzsics, Florentin Baur, Matthias Peindl, Christian Werno

Mol Ther Oncol· March 2024

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Ex vivo expansion of lung cancer-derived disseminated cancer cells from lymph nodes identifies cells associated with metastatic progression.
Steffi Treitschke, Kathrin Weidele, Adithi Ravikumar Varadarajan, Giancarlo Feliciello, Jens Warfsmann, Christian Werno

Int J Cancer· November 2023

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Single-cell microRNA sequencing method comparison and application to cell lines and circulating lung tumor cells.
Sarah M Hücker, Tobias Fehlmann, Christian Werno, Kathrin Weidele, Florian Lüke

Nat Commun· July 2021

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Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency.
Melanie Werner-Klein, Ana Grujovic, Christoph Irlbeck, Milan Obradović, Martin Hoffmann, Christian Werno

Nat Commun· October 2020

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Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma.
Melanie Werner-Klein, Sebastian Scheitler, Martin Hoffmann, Isabelle Hodak, Klaus Dietz, Christian Werno

Nat Commun· February 2018

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Early dissemination seeds metastasis in breast cancer.
Hedayatollah Hosseini, Milan M S Obradović, Martin Hoffmann, Kathryn L Harper, Maria Soledad Sosa, Christian Werno

Nature· December 2016

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Immune humanization of immunodeficient mice using diagnostic bone marrow aspirates from carcinoma patients.
Melanie Werner-Klein, Judith Proske, Christian Werno, Katharina Schneider, Hans-Stefan Hofmann

PLoS One· June 2015

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Knockout of HIF-1α in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses.
Christian Werno, Heidi Menrad, Andreas Weigert, Nathalie Dehne, Sergij Goerdt

Carcinogenesis· October 2010

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A combination of hypoxia and lipopolysaccharide activates tristetraprolin to destabilize proinflammatory mRNAs such as tumor necrosis factor-alpha.
Christian Werno, Tobias Schmid, Steffen E Schnitzer, Kathrin Peters, Larissa Milke

Am J Pathol· September 2010

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Roles of hypoxia-inducible factor-1alpha (HIF-1alpha) versus HIF-2alpha in the survival of hepatocellular tumor spheroids.
Heidi Menrad, Christian Werno, Tobias Schmid, Ekaterini Copanaki, Thomas Deller

Hepatology· June 2010

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Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype.
Andreas Weigert, Susanne Schiffmann, Divya Sekar, Stephanie Ley, Heidi Menrad, Christian Werno

Int J Cancer· November 2009

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The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1alpha in macrophages via sphingosine-1-phosphate and transforming growth factor-beta.
Barbara Herr, Jie Zhou, Christian Werno, Heidi Menrad, Dmitry Namgaladze

Blood· September 2009

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A23187, ionomycin and thapsigargin upregulate mRNA of HIF-1alpha via endoplasmic reticulum stress rather than a rise in intracellular calcium.
Christian Werno, Jie Zhou, Bernhard Brüne

J Cell Physiol· June 2008

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