Publications by authors named "Christo Muller"

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Pharmacological activation of Nrf2: Cardioprotective effects of statins and metformin against dyslipidemia-induced oxidative stress.
Sinenhlanhla X H Mthembu, Sithandiwe E Mazibuko-Mbeje, Khanyisani Ziqubu, Sonia Silvestri, Patrick Orlando, Christo J F Muller

Atherosclerosis· October 2025

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Effects of Baobab fruit powder on gut and cardiometabolic health in obesity-Protocol for a randomised placebo-controlled trial.
Sylvia Riedel, Keren de Buys, Abegail M Tshivhase, Amy E Mendham, Pieter Venter, Christo J F Muller

PLoS One· August 2025

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Prolonged exposure to simvastatin affects coenzyme Q status leading to impaired mitochondrial respiratory capacity and reduced viability of cultured cardiac cells.
Sinenhlanhla X H Mthembu, Sithandiwe E Mazibuko-Mbeje, Sonia Silvestri, Patrick Orlando, Bongani B Nkambule, Christo J F Muller

Toxicol In Vitro· June 2025

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Upstream SARS-CoV-2 variant surveillance at Breede Valley municipality using wastewater-based epidemiology.
Kholofelo Malemela, Noluxabiso Mangwana, Stephanie Dias, Jyoti Rajan Sharma, Pritika Ramharack, Christo Muller

Sci Total Environ· June 2025

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Supplementation with aspalathin and sulforaphane protects cultured cardiac cells against dyslipidemia-associated oxidative damage.
Sinenhlanhla X H Mthembu, Sithandiwe E Mazibuko-Mbeje, Sonia Silvestri, Patrick Orlando, Bongani B Nkambule, Christo J F Muller

Metabol Open· March 2025

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Blood-Based DNA Methylation Biomarkers to Identify Risk and Progression of Cardiovascular Disease.
Tarryn Willmer, Lawrence Mabasa, Jyoti Sharma, Christo J F Muller, Rabia Johnson

Int J Mol Sci· March 2025

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The Effect of Metformin and Hydrochlorothiazide on Cytochrome P450 3A4 Metabolism of Ivermectin: Insights from In Silico Experimentation.
Thuli R Mtambo, Kgothatso E Machaba, Nireshni Chellan, Pritika Ramharack, Christo J F Muller

Int J Mol Sci· November 2024

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One Year of Wastewater Surveillance in South Africa Supporting COVID-19 Clinical Findings Across Two Waves of Infection.
Renée Street, Angela Mathee, Tarylee Reddy, Nomfundo T Mahlangeni, Noluxabiso Mangwana, Christo Muller

Microorganisms· November 2024

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Low levels and partial exposure to palmitic acid improves mitochondrial function and the oxidative status of cultured cardiomyoblasts.
Sinenhlanhla X H Mthembu, Sithandiwe E Mazibuko-Mbeje, Sonia Silvestri, Patrick Orlando, Fabio Marcheggiani, Christo J F Muller

Toxicol Rep· June 2024

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Afriplex GRTTM extract attenuates hepatic steatosis in an in vitro model of NAFLD.
Kwazi Gabuza, Thendo I Mabuda, Oelfah Patel, Noxolo Khuboni, Ruzayda van Aarde, Christo J F Muller

PLoS One· April 2024

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Potential regulatory role of PGC-1α within the skeletal muscle during metabolic adaptations in response to high-fat diet feeding in animal models.
Sinenhlanhla X H Mthembu, Sithandiwe E Mazibuko-Mbeje, Khanyisani Ziqubu, Ndivhuwo Muvhulawa, Fabio Marcheggiani, Christo J F Muller

Pflugers Arch· March 2024

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Pancreatic beta cell regenerative potential of Zanthoxylum chalybeum Engl. Aqueous stem bark extract.
Clare Njoki Kimani, Helmuth Reuter, Sanet Henriët Kotzé, Pieter Venter, Pritika Ramharack, Christo John Frederick Muller

J Ethnopharmacol· February 2024

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A high fat, high sugar diet induces hepatic Peroxisome proliferator-activated receptor gamma coactivator 1-alpha promoter hypermethylation in male Wistar rats.
Yoonus Abrahams, Tarryn Willmer, Oelfah Patel, Ebrahim Samodien, Christo J F Muller

Biochem Biophys Res Commun· November 2023

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Sulforaphane: A nutraceutical against diabetes-related complications.
Sinenhlanhla X H Mthembu, Sithandiwe E Mazibuko-Mbeje, Marakiya T Moetlediwa, Ndivhuwo Muvhulawa, Sonia Silvestri, Christo J F Muller

Pharmacol Res· October 2023

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Regeneration of Pancreatic Beta Cells by Modulation of Molecular Targets Using Plant-Derived Compounds: Pharmacological Mechanisms and Clinical Potential.
Clare Njoki Kimani, Helmuth Reuter, Sanet Henriët Kotzé, Christo John Fredrick Muller

Curr Issues Mol Biol· July 2023

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Wastewater-based SARS-CoV-2 airport surveillance: key trends at the Cape Town International Airport.
Sizwe Nkambule, Rabia Johnson, Angela Mathee, Nomfundo Mahlangeni, Candice Webster, Christo Muller

J Water Health· March 2023

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Impact of dyslipidemia in the development of cardiovascular complications: Delineating the potential therapeutic role of coenzyme Q.
Sinenhlanhla X H Mthembu, Patrick Orlando, Sonia Silvestri, Khanyisani Ziqubu, Sithandiwe E Mazibuko-Mbeje, Christo J F Muller

Biochimie· January 2023

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Using Wastewater Surveillance to Compare COVID-19 Outbreaks during the Easter Holidays over a 2-Year Period in Cape Town, South Africa.
Nomfundo Mahlangeni, Renée Street, Suranie Horn, Angela Mathee, Noluxabiso Mangwana, Christo Muller

Viruses· January 2023

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Sewage surveillance of SARS-CoV-2 at student campus residences in the Western Cape, South Africa.
Noluxabiso Mangwana, Edward Archer, Christo J F Muller, Wolfgang Preiser, Gideon Wolfaardt

Sci Total Environ· December 2022

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Identification of Antidiabetic Compounds from the Aqueous Extract of Leaves.
Vinesh Maharaj, Chidinma Christiana Ezeofor, Dashnie Naidoo Maharaj, Christo J F Muller, Nnini Jennifer Obonye

Molecules· November 2022

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Delineating the Spread and Prevalence of SARS-CoV-2 Omicron Sublineages (BA.1-BA.5) and Deltacron Using Wastewater in the Western Cape, South Africa.
Rabia Johnson, Noluxabiso Mangwana, Jyoti R Sharma, Christo J F Muller, Kholofelo Malemela

J Infect Dis· October 2022

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In vitro and in vivo hepatotoxicity study of Afriplex™ GRT through an inflammatory response.
Kwazikwakhe B Gabuza, Ntandoyenkosi Buthelezi, Abidemi Paul Kappo, Thendo I Mabuda, Rebamang Mosa, Christo J F Muller

Toxicol Rep· October 2022

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Aspalathin-rich green rooibos tea in combination with glyburide and atorvastatin enhances lipid metabolism in a mouse model.
Oelfah Patel, Christo J F Muller, Elizabeth Joubert, Bernd Rosenkranz, Johan Louw

Front Clin Diabetes Healthc· October 2022

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Aspalathus linearis suppresses cell survival and proliferation of enzalutamide-resistant prostate cancer cells via inhibition of c-Myc and stability of androgen receptor.
Bi-Juan Wang, Shih-Han Huang, Cheng-Li Kao, Christo J F Muller, Ya-Pei Wang

PLoS One· July 2022

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The Effect of Phytochemicals and Food Bioactive Compounds on Diabetes.
Kazumi Yagasaki, Christo J F Muller

Int J Mol Sci· July 2022

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