Publications by authors named "Christof Haffner"

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Inhaled nitric oxide suppresses neuroinflammation in experimental ischemic stroke.
Rebecca I Sienel, Uta Mamrak, Janina Biller, Stefan Roth, Andreas Zellner, Christof Haffner

J Neuroinflammation· December 2023

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The emerging role of the HTRA1 protease in brain microvascular disease.
Christof Haffner

Front Dement· April 2023

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Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates.
Andreas Zellner, Stephan A Müller, Barbara Lindner, Nathalie Beaufort, Annemieke J M Rozemuller, Christof Haffner

Acta Neuropathol Commun· January 2022

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Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities.
Rainer Malik, Nathalie Beaufort, Simon Frerich, Benno Gesierich, Marios K Georgakis, Christof Haffner

Brain· October 2021

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Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability.
Yaw Asare, Thomas A Campbell-James, Yury Bokov, Lydia Luya Yu, Matthias Prestel, Christof Haffner

Circ Res· August 2020

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TMEM147 interacts with lamin B receptor, regulates its localization and levels, and affects cholesterol homeostasis.
Andri Christodoulou, Giannis Maimaris, Andri Makrigiorgi, Evelina Charidemou, Christian Lüchtenborg, Christof Haffner

J Cell Sci· August 2020

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Proteostasis in Cerebral Small Vessel Disease.
Christof Haffner

Front Neurosci· November 2019

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The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of via E2F3 and Rb1.
Matthias Prestel, Caroline Prell-Schicker, Tom Webb, Rainer Malik, Barbara Lindner, Monika Rex-Haffner, Christof Haffner

Stroke· October 2019

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Novel mutation in in a family with diffuse white matter lesions and inflammatory features.
Amin Ziaei, Xiaohong Xu, Leila Dehghani, Carine Bonnard, Andreas Zellner, Christof Haffner

Neurol Genet· August 2019

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CADASIL brain vessels show a HTRA1 loss-of-function profile.
Andreas Zellner, Eva Scharrer, Thomas Arzberger, Chio Oka, Valérie Domenga-Denier, Christof Haffner

Acta Neuropathol· July 2018

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Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke.
Stefan Roth, Vikramjeet Singh, Steffen Tiedt, Lisa Schindler, Georg Huber, Christof Haffner

Sci Transl Med· March 2018

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The choroid plexus is a key cerebral invasion route for T cells after stroke.
Gemma Llovera, Corinne Benakis, Gaby Enzmann, Ruiyao Cai, Thomas Arzberger, Christof Haffner

Acta Neuropathol· December 2017

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CADASIL, CARASIL, CARASAL: The linguistic subtleties of cerebral small vessel disease.
Christof Haffner, Harry V Vinters

Neurology· October 2016

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Therapeutic NOTCH3 cysteine correction in CADASIL using exon skipping: in vitro proof of concept.
Julie W Rutten, Hans G Dauwerse, Dorien J M Peters, Andrew Goldfarb, Hanka Venselaar, Christof Haffner

Brain· April 2016

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Genetic factors in cerebral small vessel disease and their impact on stroke and dementia.
Christof Haffner, Rainer Malik, Martin Dichgans

J Cereb Blood Flow Metab· January 2016

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Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease.
Edgard Verdura, Dominique Hervé, Eva Scharrer, Maria Del Mar Amador, Lucie Guyant-Maréchal, Christof Haffner

Brain· August 2015

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Response to Letter Regarding Article, "Cysteine-Sparing CADASIL Mutations in NOTCH3 Show Proaggregatory Properties In Vitro".
Frank Arne Wollenweber, Christof Haffner, Marco Duering

Stroke· June 2015

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A novel HTRA1 exon 2 mutation causes loss of protease activity in a Pakistani CARASIL patient.
Zhaleh Khaleeli, Zane Jaunmuktane, Nathalie Beaufort, Henry Houlden, Christof Haffner

J Neurol· May 2015

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Reply to Liu et al.: Loss of TGF-β signaling in CARASIL pathogenesis.
Nathalie Beaufort, Eva Scharrer, Vanda Lux, Michael Ehrmann, Christof Haffner

Proc Natl Acad Sci U S A· April 2015

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Cysteine-sparing CADASIL mutations in NOTCH3 show proaggregatory properties in vitro.
Frank Arne Wollenweber, Patrizia Hanecker, Anna Bayer-Karpinska, Rainer Malik, Hansjörg Bäzner, Christof Haffner

Stroke· March 2015

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Deficiency of the stroke relevant HDAC9 gene attenuates atherosclerosis in accord with allele-specific effects at 7p21.1.
Sepiede Azghandi, Caroline Prell, Sander W van der Laan, Manuela Schneider, Rainer Malik, Christof Haffner

Stroke· January 2015

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Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling.
Nathalie Beaufort, Eva Scharrer, Elisabeth Kremmer, Vanda Lux, Michael Ehrmann, Christof Haffner

Proc Natl Acad Sci U S A· November 2014

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Sequestration of latent TGF-β binding protein 1 into CADASIL-related Notch3-ECD deposits.
Jessica Kast, Patrizia Hanecker, Nathalie Beaufort, Armin Giese, Anne Joutel, Christof Haffner

Acta Neuropathol Commun· August 2014

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Co-aggregate formation of CADASIL-mutant NOTCH3: a single-particle analysis.
Marco Duering, Anna Karpinska, Stefanie Rosner, Franziska Hopfner, Martin Zechmeister, Christof Haffner

Hum Mol Genet· August 2011

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Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex.
Ulf Dettmer, Peer-Hendrik Kuhn, Claudia Abou-Ajram, Stefan F Lichtenthaler, Marcus Krüger, Christof Haffner

J Biol Chem· August 2010

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