Publications by authors named "Christof Zitt"

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A phase 1b/2 study evaluating efficacy and safety of MP0250, a designed ankyrin repeat protein (DARPin) simultaneously targeting vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), in combination with bortezomib and dexamethasone, in patients with relapsed or refractory multiple myeloma.
Stefan Knop, Monika Szarejko, Norbert Grząśko, Sara Bringhen, Karolin Trautmann-Grill, Christof Zitt

EJHaem· October 2024

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The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell-Mediated Killing of AML Leukemic Stem Cells.
Matteo Bianchi, Christian Reichen, Amelie Croset, Stefanie Fischer, Aline Eggenschwiler, Christof Zitt

Cancer Immunol Res· July 2024

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Ensovibep, a SARS-CoV-2 antiviral designed ankyrin repeat protein, is safe and well tolerated in healthy volunteers: Results of a first-in-human, ascending single-dose Phase 1 study.
Nina Stojcheva, Stacy Gladman, Marianne Soergel, Christof Zitt, Roxana Drake

Br J Clin Pharmacol· July 2023

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Viral clearance, pharmacokinetics and tolerability of ensovibep in patients with mild to moderate COVID-19: A phase 2a, open-label, single-dose escalation study.
Manon L M Prins, Johan L van der Plas, Maurits F J M Vissers, Cécile L Berends, Gaby Tresch, Christof Zitt

Br J Clin Pharmacol· March 2023

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The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
Sylvia Rothenberger, Daniel L Hurdiss, Marcel Walser, Francesca Malvezzi, Jennifer Mayor, Christof Zitt

Nat Biotechnol· December 2022

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A Case of Sustained Tumor Regression With MP0274, a Novel DARPin Therapeutic Targeting Human Epidermal Growth Factor Receptor 2 Signaling, in Metastatic Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer After Prior Trastuzumab and Pertuzumab.
Stefanie Fischer, Thorsten O Götze, Aurelius Omlin, Richard D Baird, Keith M Dawson, Christof Zitt

JCO Precis Oncol· November 2022

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First-in-Human Phase I Study of MP0250, a First-in-Class DARPin Drug Candidate Targeting VEGF and HGF, in Patients With Advanced Solid Tumors.
Richard D Baird, Constanza Linossi, Mark Middleton, Simon Lord, Adrian Harris, Christof Zitt

J Clin Oncol· January 2021

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Design and characterization of MP0250, a tri-specific anti-HGF/anti-VEGF DARPin® drug candidate.
H Kaspar Binz, Talitha R Bakker, Douglas J Phillips, Andreas Cornelius, Christof Zitt

MAbs· July 2018

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Half-life extension using serum albumin-binding DARPin® domains.
Daniel Steiner, Frieder W Merz, Ivo Sonderegger, Maya Gulotti-Georgieva, Denis Villemagne, Christof Zitt

Protein Eng Des Sel· September 2017

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Structure-activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action.
Yithachu Thur, Amit Bhalerao, Zaki Munshi, Nisha Pansare, Klaus Mann, Christof Zitt

Bioorg Med Chem Lett· December 2012

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Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells.
Hongli Dong, Christof Zitt, Cornelia Auriga, Armin Hatzelmann, Paul M Epstein

Biochem Pharmacol· February 2010

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Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.
Daniel Peter, S L Catherine Jin, Marco Conti, Armin Hatzelmann, Christof Zitt

J Immunol· April 2007

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PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes.
Natascha Hermann-Kleiter, Nikolaus Thuille, Christa Pfeifhofer, Thomas Gruber, Michaela Schäfer, Christof Zitt

Blood· June 2006

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Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2.
Christof Zitt, Bettina Strauss, Eva C Schwarz, Nicola Spaeth, Georg Rast

J Biol Chem· March 2004

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Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD.
Inka Heiner, Jörg Eisfeld, Christian R Halaszovich, Edith Wehage, Eberhard Jüngling, Christof Zitt

Biochem J· May 2003

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Structural domains required for channel function of the mouse transient receptor potential protein homologue TRP1beta.
Michael Engelke, Olaf Friedrich, Petra Budde, Christina Schäfer, Ursula Niemann, Christof Zitt

FEBS Lett· July 2002

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Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose.
Edith Wehage, Jörg Eisfeld, Inka Heiner, Eberhard Jüngling, Christof Zitt

J Biol Chem· June 2002

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The TRP family of cation channels: probing and advancing the concepts on receptor-activated calcium entry.
Christof Zitt, Christian R Halaszovich, Andreas Lückhoff

Prog Neurobiol· March 2002

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