Publications by authors named "Christopher Brower"

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BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43.
Yasar Arfat T Kasu, Akshaya Arva, Jess Johnson, Christin Sajan, Jasmin Manzano, Christopher S Brower

iScience· May 2022

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The Ligand of Ate1 is intrinsically disordered and participates in nucleolar phase separation regulated by Jumonji Domain Containing 6.
Akshaya Arva, Yasar Arfat T Kasu, Jennifer Duncan, Mosleh A Alkhatatbeh, Christopher S Brower

Proc Natl Acad Sci U S A· January 2021

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Beta-amyloid induces apoptosis of neuronal cells by inhibition of the Arg/N-end rule pathway proteolytic activity.
Olga I Kechko, Irina Yu Petrushanko, Christopher S Brower, Alexei A Adzhubei, Alexey A Moskalev

Aging (Albany NY)· August 2019

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The N Termini of TAR DNA-Binding Protein 43 (TDP43) C-Terminal Fragments Influence Degradation, Aggregation Propensity, and Morphology.
Yasar Arfat T Kasu, Samrawit Alemu, Angela Lamari, Nicole Loew, Christopher S Brower

Mol Cell Biol· October 2018

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Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays.
Brandon Wadas, Konstantin I Piatkov, Christopher S Brower, Alexander Varshavsky

J Biol Chem· September 2016

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Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway.
Yu-Jiao Liu, Chao Liu, ZeNan Chang, Brandon Wadas, Christopher S Brower

J Biol Chem· April 2016

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The Impact of College Student Financial Health on Other Dimensions of Health.
James E Bemel, Christopher Brower, Alyssa Chischillie, Jessica Shepherd

Am J Health Promot· March 2016

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Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats.
Christopher S Brower, Connor E Rosen, Richard H Jones, Brandon C Wadas, Konstantin I Piatkov

Proc Natl Acad Sci U S A· November 2014

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Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway.
Christopher S Brower, Konstantin I Piatkov, Alexander Varshavsky

Mol Cell· April 2013

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The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments.
Konstantin I Piatkov, Christopher S Brower, Alexander Varshavsky

Proc Natl Acad Sci U S A· July 2012

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Mouse Dfa is a repressor of TATA-box promoters and interacts with the Abt1 activator of basal transcription.
Christopher S Brower, Lucia Veiga, Richard H Jones, Alexander Varshavsky

J Biol Chem· May 2010

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Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations.
Christopher S Brower, Alexander Varshavsky

PLoS One· November 2009

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Glutamine-specific N-terminal amidase, a component of the N-end rule pathway.
Haiqing Wang, Konstantin I Piatkov, Christopher S Brower, Alexander Varshavsky

Mol Cell· June 2009

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Arginyltransferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms.
Rong-Gui Hu, Christopher S Brower, Haiqing Wang, Ilia V Davydov, Jun Sheng

J Biol Chem· October 2006

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A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.
Chieri Tomomori-Sato, Shigeo Sato, Tari J Parmely, Charles A S Banks, Irina Sorokina, Christopher S Brower

J Biol Chem· February 2004

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A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.
Shigeo Sato, Chieri Tomomori-Sato, Charles A S Banks, Tari J Parmely, Irina Sorokina, Christopher S Brower

J Biol Chem· December 2003

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Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.
Shigeo Sato, Chieri Tomomori-Sato, Charles A S Banks, Irina Sorokina, Tari J Parmely, Christopher S Brower

J Biol Chem· April 2003

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A molecular basis for stabilization of the von Hippel-Lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase.
Takumi Kamura, Christopher S Brower, Ronald C Conaway, Joan W Conaway

J Biol Chem· August 2002

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Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.
Christopher S Brower, Shigeo Sato, Chieri Tomomori-Sato, Takumi Kamura, Arnim Pause

Proc Natl Acad Sci U S A· August 2002

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Emerging roles of ubiquitin in transcription regulation.
Ronald C Conaway, Christopher S Brower, Joan Weliky Conaway

Science· May 2002

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