Publications by authors named "Christopher C Frye"

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Investigating the impact of synonymous gene recoding on a recombinantly expressed monoclonal antibody under different process parameters.
Nayiri M Kaissarian, Stephanie L Sandefur, Arnab Ghosh, Upendra K Katneni, Wendy Walton, Christopher C Frye

Bioeng Transl Med· May 2025

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Differential expression of miRNAs and functional role of mir-200a in high and low productivity CHO cells expressing an Fc fusion protein.
Laura Bryan, Michael Henry, Niall Barron, Clair Gallagher, Ronan M Kelly, Christopher C Frye

Biotechnol Lett· August 2021

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Mapping the molecular basis for growth related phenotypes in industrial producer CHO cell lines using differential proteomic analysis.
Laura Bryan, Michael Henry, Ronan M Kelly, Christopher C Frye, Matthew D Osborne

BMC Biotechnol· July 2021

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CRISPR/Cas12a-mediated CHO genome engineering can be effectively integrated at multiple stages of the cell line generation process for bioproduction.
Patrick G Schweickert, Ning Wang, Stephanie L Sandefur, Michael E Lloyd, Stephen F Konieczny, Christopher C Frye

Biotechnol J· April 2021

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Transcriptomic analysis of IgG4 Fc-fusion protein degradation in a panel of clonally-derived CHO cell lines using RNASeq.
Colin Clarke, Clair Gallagher, Ronan M Kelly, Michael Henry, Paula Meleady, Christopher C Frye

Biotechnol Bioeng· June 2019

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Elucidating the Impact of CHO Cell Culture Media on Tryptophan Oxidation of a Monoclonal Antibody Through Gene Expression Analyses.
Luhong He, Jairav X Desai, Jinxin Gao, Laurie B Hazeltine, Zhirui Lian, Christopher C Frye

Biotechnol J· October 2018

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Clonal variation in productivity and proteolytic clipping of an Fc-fusion protein in CHO cells: Proteomic analysis suggests a role for defective protein folding and the UPR.
Michael Henry, Clair Gallagher, Ronan M Kelly, Christopher C Frye, Matthew D Osborne

J Biotechnol· September 2018

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Effective and efficient characterization of Chinese hamster ovary production cell lines using automated intracellular staining and statistical modeling.
Lara E Krebs, Daniel M Bowden, Christopher M Bray, Margaret M Shaw, Christopher C Frye

Biotechnol Prog· May 2018

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Modulation of IgG1 immunoeffector function by glycoengineering of the GDP-fucose biosynthesis pathway.
Ronan M Kelly, Ronald L Kowle, Zhirui Lian, Beth A Strifler, Derrick R Witcher, Christopher C Frye

Biotechnol Bioeng· March 2018

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Evaluation of piggyBac-mediated CHO pools to enable material generation to support GLP toxicology studies.
Yashas Rajendra, Sowmya Balasubramanian, Neil A McCracken, Dawn L Norris, Zhirui Lian, Christopher C Frye

Biotechnol Prog· November 2017

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Bioreactor scale up and protein product quality characterization of piggyBac transposon derived CHO pools.
Yashas Rajendra, Sowmya Balasubramanian, Robert B Peery, James R Swartling, Neil A McCracken, Christopher C Frye

Biotechnol Prog· March 2017

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Polysorbates 20 and 80 Degradation by Group XV Lysosomal Phospholipase A2 Isomer X1 in Monoclonal Antibody Formulations.
Troii Hall, Stephanie L Sandefur, Christopher C Frye, Tammy L Tuley, Lihua Huang

J Pharm Sci· May 2016

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Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319.
Alexei Kharitonenkov, John M Beals, Radmila Micanovic, Beth A Strifler, Radhakrishnan Rathnachalam, Christopher C Frye

PLoS One· December 2013

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Development of a highly-efficient CHO cell line generation system with engineered SV40E promoter.
Lianchun Fan, Ibrahim Kadura, Lara E Krebs, Jeffery L Larson, Daniel M Bowden, Christopher C Frye

J Biotechnol· December 2013

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Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells.
Lianchun Fan, Ibrahim Kadura, Lara E Krebs, Christopher C Hatfield, Margaret M Shaw, Christopher C Frye

Biotechnol Bioeng· April 2012

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