Publications by authors named "Christopher D Lima"

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Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase.
Vladimir Baytshtok, Michael A DiMattia, Christopher D Lima

Nat Commun· July 2025

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Chemical Tools for Probing the Ub/Ubl Conjugation Cascades.
Tomasz Kochańczyk, Michael Fishman, Christopher D Lima

Chembiochem· January 2025

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Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase.
Vladimir Baytshtok, Michael A DiMattia, Christopher D Lima

bioRxiv· December 2024

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Structural basis for transthiolation intermediates in the ubiquitin pathway.
Tomasz Kochańczyk, Zachary S Hann, Michaelyn C Lux, Avelyn Mae V Delos Reyes, Cheng Ji, Christopher D Lima

Nature· September 2024

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Design and Semisynthesis of Biselectrophile-Functionalized Ubiquitin Probes To Investigate Transthioesterification Reactions.
Avelyn Mae V Delos Reyes, Michaelyn C Lux, Zachary S Hann, Cheng Ji, Tomasz Kochańczyk, Christopher D Lima

Org Lett· June 2024

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SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex.
Hyein G Lee, Abigail A Lemmon, Christopher D Lima

Proc Natl Acad Sci U S A· January 2023

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Methods to assess helicase and translocation activities of human nuclear RNA exosome and RNA adaptor complexes.
M Rhyan Puno, Christopher D Lima

Methods Enzymol· August 2022

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Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex.
M Rhyan Puno, Christopher D Lima

Cell· June 2022

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YTHDC2 control of gametogenesis requires helicase activity but not mA binding.
Yuhki Saito, Ben R Hawley, M Rhyan Puno, Shreya N Sarathy, Christopher D Lima

Genes Dev· February 2022

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DNA asymmetry promotes SUMO modification of the single-stranded DNA-binding protein RPA.
Laurent Cappadocia, Tomasz Kochańczyk, Christopher D Lima

EMBO J· November 2021

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RNA helicases are hubs that orchestrate exosome-dependent 3'-5' decay.
Eva-Maria Weick, Christopher D Lima

Curr Opin Struct Biol· April 2021

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Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome.
Mom Das, Dimitrios Zattas, John C Zinder, Elizabeth V Wasmuth, Julien Henri, Christopher D Lima

Proc Natl Acad Sci U S A· April 2021

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Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions.
John Ginn, Xiuju Jiang, Shan Sun, Mayako Michino, David J Huggins, Christopher D Lima

ACS Infect Dis· February 2021

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Strategies for Generating RNA Exosome Complexes from Recombinant Expression Hosts.
Eva-Maria Weick, John C Zinder, Christopher D Lima

Methods Mol Biol· December 2020

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Reconstitution of S. cerevisiae RNA Exosome Complexes Using Recombinantly Expressed Proteins.
John C Zinder, Christopher D Lima

Methods Mol Biol· December 2020

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Reconstitution of the Schizosaccharomyces pombe RNA Exosome.
Kurt Januszyk, Christopher D Lima

Methods Mol Biol· December 2020

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Reconstitution of the Human Nuclear RNA Exosome.
Kurt Januszyk, Eva-Maria Weick, Christopher D Lima

Methods Mol Biol· December 2020

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Substrate selectivity by the exonuclease Rrp6p.
Armend Axhemi, Elizabeth V Wasmuth, Christopher D Lima, Eckhard Jankowsky

Proc Natl Acad Sci U S A· January 2020

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SnapShot: The RNA Exosome.
M Rhyan Puno, Eva-Maria Weick, Mom Das, Christopher D Lima

Cell· September 2019

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Crystal structure of the Schizosaccharomyces pombe U7BR E2-binding region in complex with Ubc7.
Zachary S Hann, Meredith B Metzger, Allan M Weissman, Christopher D Lima

Acta Crystallogr F Struct Biol Commun· August 2019

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Structural basis for adenylation and thioester bond formation in the ubiquitin E1.
Zachary S Hann, Cheng Ji, Shaun K Olsen, Xuequan Lu, Michaelyn C Lux, Christopher D Lima

Proc Natl Acad Sci U S A· July 2019

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Strategies to Trap Enzyme-Substrate Complexes that Mimic Michaelis Intermediates During E3-Mediated Ubiquitin-Like Protein Ligation.
Frederick C Streich, Christopher D Lima

Methods Mol Biol· May 2019

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Discovery and engineering of enhanced SUMO protease enzymes.
Yue-Ting K Lau, Vladimir Baytshtok, Tessa A Howard, Brooke M Fiala, JayLee M Johnson, Christopher D Lima

J Biol Chem· August 2018

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Structural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex.
M Rhyan Puno, Christopher D Lima

Proc Natl Acad Sci U S A· June 2018

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Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex.
Eva-Maria Weick, M Rhyan Puno, Kurt Januszyk, John C Zinder, Michael A DiMattia, Christopher D Lima

Cell· June 2018

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