Publications by authors named "Christopher D Link"

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Multielectrode array characterization of human induced pluripotent stem cell derived neurons in co-culture with primary human astrocytes.
Maddie R Lemieux, Bernhard Freigassner, Jessica L Hanson, Zahra Thathey, Mark R Opp, Christopher D Link

PLoS One· June 2024

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Multielectrode array characterization of human induced pluripotent stem cell derived neurons in co-culture with primary human astrocytes.
Maddie R Lemieux, Bernhard Freigassner, Zahra Thathey, Mark R Opp, Charles A Hoeffer, Christopher D Link

bioRxiv· March 2024

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TDP-43 knockdown in mouse model of ALS leads to dsRNA deposition, gliosis, and neurodegeneration in the spinal cord.
Ryan A Milstead, Christopher D Link, Zuoshang Xu, Charles A Hoeffer

Cereb Cortex· May 2023

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The reverse transcriptase inhibitor 3TC protects against age-related cognitive dysfunction.
Devin Wahl, Meghan E Smith, Cali M McEntee, Alyssa N Cavalier, Shelby C Osburn, Christopher D Link

Aging Cell· May 2023

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Identifying an Optimal Neuroinflammation Treatment Using a Nanoligomer Discovery Engine.
Sadhana Sharma, Curtis Borski, Jessica Hanson, Micklaus A Garcia, Christopher D Link

ACS Chem Neurosci· December 2022

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Amyloid beta acts synergistically as a pro-inflammatory cytokine.
Thomas J LaRocca, Alyssa N Cavalier, Christine M Roberts, Maddie R Lemieux, Pooja Ramesh, Christopher D Link

Neurobiol Dis· November 2021

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Application of a bioinformatic pipeline to RNA-seq data identifies novel virus-like sequence in human blood.
Marko Melnick, Patrick Gonzales, Thomas J LaRocca, Yuping Song, Joanne Wuu, Christopher D Link

G3 (Bethesda)· September 2021

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Is There a Brain Microbiome?
Christopher D Link

Neurosci Insights· May 2021

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The gut microbiome-derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging.
Vienna E Brunt, Thomas J LaRocca, Amy E Bazzoni, Zachary J Sapinsley, Jill Miyamoto-Ditmon, Christopher D Link

Geroscience· February 2021

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Heat shock in C. elegans induces downstream of gene transcription and accumulation of double-stranded RNA.
Marko Melnick, Patrick Gonzales, Joseph Cabral, Mary A Allen, Robin D Dowell, Christopher D Link

PLoS One· December 2019

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TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes.
Thomas J LaRocca, Andrea Mariani, Linda R Watkins, Christopher D Link

Neurobiol Dis· December 2019

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Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation.
David Guerrero-Gómez, José Antonio Mora-Lorca, Beatriz Sáenz-Narciso, Francisco José Naranjo-Galindo, Fernando Muñoz-Lobato, Christopher D Link

Cell Death Differ· September 2019

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α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer's disease.
Dylan Shea, Cheng-Chieh Hsu, Timothy M Bi, Natasha Paranjapye, Matthew Carter Childers, Christopher D Link

Proc Natl Acad Sci U S A· April 2019

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Heterochromatin anomalies and double-stranded RNA accumulation underlie poly(PR) toxicity.
Yong-Jie Zhang, Lin Guo, Patrick K Gonzales, Tania F Gendron, Yanwei Wu, Christopher D Link

Science· February 2019

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Neurodegeneration, Heterochromatin, and Double-Stranded RNA.
Tassa K Saldi, Patrick K Gonzales, Thomas J LaRocca, Christopher D Link

J Exp Neurosci· February 2019

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In vivo induction of membrane damage by β-amyloid peptide oligomers.
Carl Julien, Colson Tomberlin, Christine M Roberts, Aumbreen Akram, Gretchen H Stein, Christopher D Link

Acta Neuropathol Commun· November 2018

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The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2.
Tassa K Saldi, Patrick Gonzales, Alfonso Garrido-Lecca, Vishantie Dostal, Christine M Roberts, Christopher D Link

Mol Cell Biol· August 2018

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Transcriptome analysis of genetically matched human induced pluripotent stem cells disomic or trisomic for chromosome 21.
Patrick K Gonzales, Christine M Roberts, Virginia Fonte, Connor Jacobsen, Gretchen H Stein, Christopher D Link

PLoS One· July 2018

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RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome.
Briana Van Treeck, David S W Protter, Tyler Matheny, Anthony Khong, Christopher D Link

Proc Natl Acad Sci U S A· March 2018

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Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients.
Mercedes Prudencio, Patrick K Gonzales, Casey N Cook, Tania F Gendron, Lillian M Daughrity, Christopher D Link

Hum Mol Genet· September 2017

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Sedimentation Velocity Analysis with Fluorescence Detection of Mutant Huntingtin Exon 1 Aggregation in Drosophila melanogaster and Caenorhabditis elegans.
Surin A Kim, Victoria F D'Acunto, Bashkim Kokona, Jennifer Hofmann, Nicole R Cunningham, Christopher D Link

Biochemistry· September 2017

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Caenorhabditis elegans as a model system to study post-translational modifications of human transthyretin.
Andrea Henze, Thomas Homann, Isabelle Rohn, Michael Aschner, Christopher D Link

Sci Rep· November 2016

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Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts.
Nicholas J Kramer, Yari Carlomagno, Yong-Jie Zhang, Sandra Almeida, Casey N Cook, Christopher D Link

Science· August 2016

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DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans.
Erin Munkácsy, Maruf H Khan, Rebecca K Lane, Megan B Borror, Jae H Park, Christopher D Link

PLoS Genet· July 2016

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C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins.
Yong-Jie Zhang, Tania F Gendron, Jonathan C Grima, Hiroki Sasaguri, Karen Jansen-West, Christopher D Link

Nat Neurosci· May 2016

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