Publications by authors named "Christopher D Steele"

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Geographic and age variations in mutational processes in colorectal cancer.
Marcos Díaz-Gay, Wellington Dos Santos, Sarah Moody, Mariya Kazachkova, Ammal Abbasi, Christopher D Steele, Raviteja Vangara, Sergey Senkin, Jingwei Wang, Stephen Fitzgerald

Nature· July 2025

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Chromothripsis and ecDNA initiated by N4BP2 nuclease fragmentation of cytoplasm-exposed chromosomes.
Ksenia Krupina, Alexander Goginashvili, Michael W Baughn, Stephen Moore, Christopher D Steele

Science· December 2025

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The mutagenic forces shaping the genomes of lung cancer in never smokers.
Marcos Díaz-Gay, Tongwu Zhang, Phuc H Hoang, Charles Leduc, Marina K Baine, Christopher D Steele

Nature· August 2025

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HRProfiler Detects Homologous Recombination Deficiency in Breast and Ovarian Cancers Using Whole-Genome and Whole-Exome Sequencing Data.
Ammal Abbasi, Christopher D Steele, Erik N Bergstrom, Azhar Khandekar, Akanksha Farswan

Cancer Res· July 2025

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Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis.
Cameron Durfee, Erik N Bergstrom, Marcos Díaz-Gay, Yufan Zhou, Nuri Alpay Temiz, Christopher D Steele

Res Sq· June 2025

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Geographic and age-related variations in mutational processes in colorectal cancer.
Marcos Díaz-Gay, Wellington Dos Santos, Sarah Moody, Mariya Kazachkova, Ammal Abbasi, Christopher D Steele

medRxiv· February 2025

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Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis.
Cameron Durfee, Erik N Bergstrom, Marcos Díaz-Gay, Yufan Zhou, Nuri Alpay Temiz, Christopher D Steele

bioRxiv· January 2025

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Detecting HRD in whole-genome and whole-exome sequenced breast and ovarian cancers.
Ammal Abbasi, Christopher D Steele, Erik N Bergstrom, Azhar Khandekar, Akanksha Farswan

medRxiv· July 2024

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The mutagenic forces shaping the genomic landscape of lung cancer in never smokers.
Marcos Díaz-Gay, Tongwu Zhang, Phuc H Hoang, Azhar Khandekar, Wei Zhao, Christopher D Steele

medRxiv· May 2024

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Visualizing and exploring patterns of large mutational events with SigProfilerMatrixGenerator.
Azhar Khandekar, Raviteja Vangara, Mark Barnes, Marcos Díaz-Gay, Ammal Abbasi, Christopher D Steele

BMC Genomics· August 2023

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Mitotic tethering enables inheritance of shattered micronuclear chromosomes.
Prasad Trivedi, Christopher D Steele, Franco K C Au, Ludmil B Alexandrov, Don W Cleveland

Nature· June 2023

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Genomic Patterns of Malignant Peripheral Nerve Sheath Tumor (MPNST) Evolution Correlate with Clinical Outcome and Are Detectable in Cell-Free DNA.
Isidro Cortes-Ciriano, Christopher D Steele, Katherine Piculell, Alyaa Al-Ibraheemi, Vanessa Eulo

Cancer Discov· March 2023

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Visualizing and exploring patterns of large mutational events with SigProfilerMatrixGenerator.
Azhar Khandekar, Raviteja Vangara, Mark Barnes, Marcos Díaz-Gay, Ammal Abbasi, Christopher D Steele

bioRxiv· February 2023

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Uncovering novel mutational signatures by extraction with SigProfilerExtractor.
S M Ashiqul Islam, Marcos Díaz-Gay, Yang Wu, Mark Barnes, Raviteja Vangara, Christopher D Steele

Cell Genom· November 2022

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An overview of mutational and copy number signatures in human cancer.
Christopher D Steele, Nischalan Pillay, Ludmil B Alexandrov

J Pathol· July 2022

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Signatures of copy number alterations in human cancer.
Christopher D Steele, Ammal Abbasi, S M Ashiqul Islam, Amy L Bowes, Azhar Khandekar

Nature· June 2022

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Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma.
Matt Lechner, Yoko Takahashi, Mario Turri-Zanoni, Jacklyn Liu, Nicholas Counsell, Christopher D Steele

Eur J Cancer· February 2022

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Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA.
Erik N Bergstrom, Jens Luebeck, Mia Petljak, Azhar Khandekar, Mark Barnes, Christopher D Steele

Nature· February 2022

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Therapeutic vulnerability to PARP1,2 inhibition in RB1-mutant osteosarcoma.
Georgia Zoumpoulidou, Carlos Alvarez-Mendoza, Caterina Mancusi, Ritika-Mahmuda Ahmed, Milly Denman, Christopher D Steele

Nat Commun· December 2021

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Whole-genome sequencing of single circulating tumor cells from neuroendocrine neoplasms.
Alexa Childs, Christopher D Steele, Clare Vesely, Francesca M Rizzo, Leah Ensell

Endocr Relat Cancer· August 2021

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Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy.
Matt Lechner, Volker H Schartinger, Christopher D Steele, Wen Long Nei, Marc Lucas Ooft

Nat Commun· January 2021

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H3K27me3 expression and methylation status in histological variants of malignant peripheral nerve sheath tumours.
Iben Lyskjaer, Daniel Lindsay, Roberto Tirabosco, Christopher D Steele, Patrick Lombard

J Pathol· October 2020

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The genomics of undifferentiated sarcoma of soft tissue: Progress, challenges and opportunities.
Christopher D Steele, Nischalan Pillay

Semin Cancer Biol· April 2020

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Undifferentiated pleomorphic sarcomas with PRDM10 fusions have a distinct gene expression profile.
Jakob Hofvander, Florian Puls, Nischalan Pillay, Christopher D Steele, Adrienne M Flanagan

J Pathol· December 2019

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Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways.
Christopher D Steele, Maxime Tarabichi, Dahmane Oukrif, Amy P Webster, Hongtao Ye

Cancer Cell· March 2019

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