原論文はこちら Nature 2025 Geographic and age variations in mutational processes in colorectal cancer https://t.co/nnnb1mob6C 国内大腸がん、5割が細菌原因か 毒素で変異、若年発症増に関係も(共同通信) https://t.co/VHqY7KYGG9
Geographic and age variations in mutational processes in colorectal cancer.
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Apr 2025 – Sep 2025Where it's discussed
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News321 articles
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X / Twitter115 posts
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AI synopsis
What people are saying
Many discussions highlight the connection between early-life exposure to the bacteria colibactin and rising rates of colorectal cancer, with users using terms like 'game changer' and 'critical issue' to describe its consequences. Phrasing such as 'new insights into mutation processes' and 'needs urgent attention' suggests that the choice of words and passionate tone significantly enhance the overall urgency and importance that the community places on this research.
Most discussions show a moderate to strong support for the findings, indicating a general consensus about the relevance of the research.
There is high curiosity surrounding the publication, with many users expressing interest in its implications and findings.
Many posts reference specific aspects of the study, such as the mutagen colibactin, but some appear more casual in their commentary.
Participants generally believe that the publication has significant implications for understanding colorectal cancer incidence.
Abstract in brief
- Incidence rates of colorectal cancer vary across regions and have increased, particularly for early-onset cases in individuals under 50, which have doubled in the last 20 years.
- The study examined colorectal cancer genomes from 11 countries, revealing no major differences in unstable cancers but noted varying mutation burdens and patterns, especially in microsatellite-stable cases.
- A specific mutagen produced by bacteria (colibactin) was associated with higher mutation loads in countries with increased colorectal cancer rates and was significantly linked to early-onset cases, suggesting that early life exposure to this mutagen might be a factor in the rising incidence.
Top posts
Most liked on X and Blueskyコリバクチンを産生する菌を減らすには腸内環境を整えることが大切で、食物繊維や発酵食品を食べ、運動をして、禁煙や節酒を心がけることが重要。 Geographic and age variations in mutational processes in colorectal cancer. Nature https://t.co/WxBcj7Kw58
New IARC study shows that early exposure to certain gut bacteria may trigger genetic changes, increasing #colorectalcancer risk decades later, especially in those under 50. Unique mutational patterns across regions stress the need for tailored prevention: https://t.co/mLtg4LrEID
柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in colorectal cancer https://t.co/Z1Cc1hyKch #オープンアクセス @NccriOfficial @UTokyo_News @UCSanDiego https://t.co/14XkZac0k6
こちら原文 Geographic and age variations in mutational processes in colorectal cancer https://t.co/vB9I8UEWjW
柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #論文 Geographic and age variations in mutational processes in colorectal cancer https://t.co/Z1Cc1hyKch 閲覧用リンク:https://t.co/lox5NQDArX @NccriOfficial @UTokyo_News @UCSanDiego https://t.co/D4Ftij6LJE
All mentions
Colorectal Cancer: The Role of Colibactin in Early-Onset Cases
This video explores the incidence rates of colorectal cancer, particularly among individuals under 50, which have doubled recently. It examines the link between colibactin, a mutagen produced by bacteria, and increased…
Rising Colon Cancer Rates Among Younger Adults Explained
Colorectal cancer (CRC) is the second leading cause of cancer deaths in the U.S., with an increased incidence among those under 50. This video explores the statistics and trends, focusing on the disparities in diagnosis…
information sources: +Rebecca Siegel et al. (2020). https://t.co/eUvb5f5Rqp +Christina Bailey et al. (2015). https://t.co/ZgedsO3JXI +Marcos Díaz-Gay et al. (2025). https://t.co/6V9GF22QA3 +Axel Rosendahl Huber et al. (2024). https://t.co/TmA2QRtFo2
RT @hernangraffe: https://t.co/8uQSA9VDtm
https://t.co/8uQSA9VDtm
RT @ekocakavuk: Geographic and age variations in mutational processes in colorectal cancer | @Nature https://t.co/luMeKc3cPn
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in…
大腸がんの変異過程における地理的および年齢による差異 Geographic and age variations in mutational processes in colorectal cancer https://t.co/W9BeD6Xeh6 #Nature誌 #大腸がん #全ゲノム解析 #コリバクチン毒素 #国際共同研究 #国立がん研究センター https://t.co/apTnlwnIiw
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in…
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in…
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in…
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in…
柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in colorectal cancer https://t.co/Z1Cc1hyKch #オープンアクセス @NccriOfficial @UTokyo_News @UCSanDiego https://t.co/14XkZac0k6
Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/71TzrHutQO
Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/rPEDoAB8Fu
大腸がんの変異過程における地理的および年齢的変動 Geographic and age variations in mutational processes in colorectal cancer https://t.co/ISFz15onGT
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in…
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in…
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in…
柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in colorectal cancer https://t.co/Z1Cc1hyKch #オープンアクセス @NccriOfficial @UTokyo_News @UCSanDiego https://t.co/uz5IJ95CQF
RT @ygjumi: Geographic and age variations in mutational processes in colorectal cancer https://t.co/WX7iiDR5OJ
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #論文 Geographic and age variations in mutational processes in colo…
Geographic and age variations in mutational processes in colorectal cancer | Nature www.nature.com/articles/s41...
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #論文 Geographic and age variations in mutational processes in colo…
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #論文 Geographic and age variations in mutational processes in colo…
柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #論文 Geographic and age variations in mutational processes in colorectal cancer https://t.co/Z1Cc1hyKch 閲覧用リンク:https://t.co/lox5NQDArX @NccriOfficial @UTokyo_News @UCSanDiego https://t.co/D4Ftij6LJE
Geographic and age variations in mutational processes in colorectal cancer https://t.co/WX7iiDR5OJ
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in…
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in…
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in…
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in…
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in…
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in…
柴田 龍弘 氏、Ludmil B. Alexandrov 氏らの #大腸がん における変異に関する@Nature #OA #論文 Geographic and age variations in mutational processes in colorectal cancer https://t.co/Z1Cc1hyKch #オープンアクセス @NccriOfficial @UTokyo_News @UCSanDiego https://t.co/UrKn1vb3xy
Geographic and age variations in mutational processes in colorectal cancer #KolonKanseri #Colibactin #Kanser #Winally https://t.co/xzAogbYMz6
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov氏らの #大腸がん における変異に関する@Nature #論文 Geographic and age variations in mutational processes in color…
Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/Q26n1Fq8Xp
参考文献
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov氏らの #大腸がん における変異に関する@Nature #論文 Geographic and age variations in mutational processes in color…
RT @HiraokaYasushi: 原論文はこちら Nature 2025 Geographic and age variations in mutational processes in colorectal cancer https://t.co/nnnb1mob6C…
@Sankei_news Díaz-Gay, M., dos Santos, W., Moody, S. et al. Geographic and age variations in mutational processes in colorectal cancer. Nature (2025). https://t.co/crELIFK32z
RT @HiraokaYasushi: 原論文はこちら Nature 2025 Geographic and age variations in mutational processes in colorectal cancer https://t.co/nnnb1mob6C…
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov氏らの #大腸がん における変異に関する@Nature #論文 Geographic and age variations in mutational processes in color…
RT @HiraokaYasushi: 原論文はこちら Nature 2025 Geographic and age variations in mutational processes in colorectal cancer https://t.co/nnnb1mob6C…
RT @ygjumi: Geographic and age variations in mutational processes in colorectal cancer https://t.co/WX7iiDR5OJ
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov氏らの #大腸がん における変異に関する@Nature #論文 Geographic and age variations in mutational processes in color…
RT @NatureJapan: 柴田 龍弘 氏、Ludmil B. Alexandrov氏らの #大腸がん における変異に関する@Nature #論文 Geographic and age variations in mutational processes in color…
柴田 龍弘 氏、Ludmil B. Alexandrov氏らの #大腸がん における変異に関する@Nature #論文 Geographic and age variations in mutational processes in colorectal cancer https://t.co/Z1Cc1hzi1P 閲覧用リンク:https://t.co/lox5NQE8hv @NccriOfficial @UTokyo_News @UCSanDiego https://t.co/bFieDVGUOT
RT @HiraokaYasushi: 原論文はこちら Nature 2025 Geographic and age variations in mutational processes in colorectal cancer https://t.co/nnnb1mob6C…
23 April 2025
https://t.co/YuO7poT6cR
RT @ma31stm: Geographic and age variations in mutational processes in colorectal cancer. https://t.co/zm3bhs4TTG
Geographic and age variations in mutational processes in colorectal cancer. https://t.co/zm3bhs4TTG https://t.co/IS3Bq3oKOw
RT @HiraokaYasushi: 原論文はこちら Nature 2025 Geographic and age variations in mutational processes in colorectal cancer https://t.co/nnnb1mob6C…
RT @HiraokaYasushi: 原論文はこちら Nature 2025 Geographic and age variations in mutational processes in colorectal cancer https://t.co/nnnb1mob6C…
原論文はこちら Nature 2025 Geographic and age variations in mutational processes in colorectal cancer https://t.co/nnnb1mob6C 国内大腸がん、5割が細菌原因か 毒素で変異、若年発症増に関係も(共同通信) https://t.co/VHqY7KYGG9
Geographic and age variations in mutational processes in colorectal cancer https://t.co/WX7iiDR5OJ
こちら原文 Geographic and age variations in mutational processes in colorectal cancer https://t.co/vB9I8UEWjW
国際共同研究により大腸がんの全ゲノム解析を実施し日本人症例を解析 日本人大腸がん患者さんの5割に特徴的な腸内細菌による発がん要因を発見(2025/05/21) www.ncc.go.jp/jp/informati... にも記されているけど、 Geographic and age variations in mutational processes in colorectal cancer (2025/04/23) www.nature.com/articles/s41... が元ネタか。 bsky.app/profile/47ne...
これか。 Geographic and age variations in mutational processes in colorectal cancer https://t.co/kzf4hcisyr https://t.co/zlFqnFsTA0
RT @GlobalPHObserv: Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/AQzmCx2U75
RT @GlobalPHObserv: Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/AQzmCx2U75
RT @GlobalPHObserv: Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/AQzmCx2U75
Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/AQzmCx2U75
Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/LLwTTYvnL2
Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/LLwTTYvnL2
RT @erlesen: Geographic and age variations in mutational processes in colorectal cancer. Signatures SBS88 and ID18, caused by the bacteria-…
RT @IARCWHO: New IARC study shows that early exposure to certain gut bacteria may trigger genetic changes, increasing #colorectalcancer ris…
RT @AndrewW66619812: The paper in "Nature" the above "Guardian" article is based upon, & links to: “Geographic and age variations in mutat…
The paper in "Nature" the above "Guardian" article is based upon, & links to: “Geographic and age variations in mutational processes in colorectal cancer” 2/2 https://t.co/iseigMSQC7
RT @ichiipsy: コリバクチンを産生する菌を減らすには腸内環境を整えることが大切で、食物繊維や発酵食品を食べ、運動をして、禁煙や節酒を心がけることが重要。 Geographic and age variations in mutational processes i…
RT @DoctorHumber: El estudio de Díaz-Gay et al. (2025) publicado en Nature encontró que:
El estudio de Díaz-Gay et al. (2025) publicado en Nature encontró que:
RT @ichiipsy: コリバクチンを産生する菌を減らすには腸内環境を整えることが大切で、食物繊維や発酵食品を食べ、運動をして、禁煙や節酒を心がけることが重要。 Geographic and age variations in mutational processes i…
RT @ichiipsy: コリバクチンを産生する菌を減らすには腸内環境を整えることが大切で、食物繊維や発酵食品を食べ、運動をして、禁煙や節酒を心がけることが重要。 Geographic and age variations in mutational processes i…
RT @ichiipsy: コリバクチンを産生する菌を減らすには腸内環境を整えることが大切で、食物繊維や発酵食品を食べ、運動をして、禁煙や節酒を心がけることが重要。 Geographic and age variations in mutational processes i…
RT @ichiipsy: コリバクチンを産生する菌を減らすには腸内環境を整えることが大切で、食物繊維や発酵食品を食べ、運動をして、禁煙や節酒を心がけることが重要。 Geographic and age variations in mutational processes i…
コリバクチンを産生する菌を減らすには腸内環境を整えることが大切で、食物繊維や発酵食品を食べ、運動をして、禁煙や節酒を心がけることが重要。 Geographic and age variations in mutational processes in colorectal cancer. Nature https://t.co/WxBcj7Kw58
... cause that became more prevalent and is now waning. Infection seems to be a good candidate for something that changes over time in this way. Colibactin producing E Coli one possibility. pubmed.ncbi.nlm.nih.gov/40267983/ 3/3
Colorectal Cancer Is Changing—And It Might Start in Your Gut Supporting evidence: Díaz-Gay, M., dos Santos, W., Moody, S. et al.Geographic and age variations in mutational processes in colorectal cancer. Nature (2025). https://t.co/MTP7Q8qrE8 https://t.co/go1IjX3FkL
Geographic and age variations in mutational processes in colorectal cancer. Signatures SBS88 and ID18, caused by the bacteria-produced mutagen colibactin www.nature.com/articles/s41... Gefahr im Essen: Bakterien könnten Darmkrebs bei Jüngeren auslösen www.t-online.de/gesundheit/a...
Geographic and age variations in mutational processes in colorectal cancer. Signatures SBS88 and ID18, caused by the bacteria-produced mutagen colibactin https://t.co/PGgYPYlg3L Gefahr im Essen: Bakterien könnten Darmkrebs bei Jüngeren auslösen https://t.co/HJ6OMRws4z
Geographic and age variations in mutational processes in colorectal cancer Díaz-Gay, M., dos Santos, W., Moody, S. et al. Geographic and age variations in mutational processes in colorectal cancer. Nature (2025). https://t.co/p0hlhKXvWH https://t.co/mQJrACux3h
RT @IARCWHO: New IARC study shows that early exposure to certain gut bacteria may trigger genetic changes, increasing #colorectalcancer ris…
Geographic and age variations in mutational processes in colorectal cancer www.nature.com/articles/s41...
RT @IARCWHO: New IARC study shows that early exposure to certain gut bacteria may trigger genetic changes, increasing #colorectalcancer ris…
RT @IARCWHO: New IARC study shows that early exposure to certain gut bacteria may trigger genetic changes, increasing #colorectalcancer ris…
RT @IARCWHO: New IARC study shows that early exposure to certain gut bacteria may trigger genetic changes, increasing #colorectalcancer ris…
RT @IARCWHO: New IARC study shows that early exposure to certain gut bacteria may trigger genetic changes, increasing #colorectalcancer ris…
RT @IARCWHO: New IARC study shows that early exposure to certain gut bacteria may trigger genetic changes, increasing #colorectalcancer ris…
Early-life mutagenic exposure to 107 colibactin-producing bacteria may contribute to the rising incidence of early-onset colorectal Díaz-Gay, et al. Geographic & age variations in mutational processes in colorectal cancer. Nature (2025). https://t.co/hbLvXMLgCh
RT @IARCWHO: New IARC study shows that early exposure to certain gut bacteria may trigger genetic changes, increasing #colorectalcancer ris…
RT @IARCWHO: New IARC study shows that early exposure to certain gut bacteria may trigger genetic changes, increasing #colorectalcancer ris…
RT @IARCWHO: New IARC study shows that early exposure to certain gut bacteria may trigger genetic changes, increasing #colorectalcancer ris…
New IARC study shows that early exposure to certain gut bacteria may trigger genetic changes, increasing #colorectalcancer risk decades later, especially in those under 50. Unique mutational patterns across regions stress the need for tailored prevention: https://t.co/mLtg4LrEID
Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/m5k3uKozr8
RT @sangerinstitute: Read ‘Geographic and age variations in mutational processes in colorectal cancer’ from @UCSanDiego and @sangerinstitu…
Geographic and age variations in mutational processes in colorectal cancer https://t.co/DDSTGh3Jj2
RT @GlobalPHObserv: Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/AQzmCx2U75
RT @GlobalPHObserv: Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/AQzmCx2U75
RT @josepereag: Geographic and age-related variations in CRC mutational profiles, suggesting that early-life mutagenic exposure to colibact…
RT @josepereag: Geographic and age-related variations in CRC mutational profiles, suggesting that early-life mutagenic exposure to colibact…
RT @josepereag: Geographic and age-related variations in CRC mutational profiles, suggesting that early-life mutagenic exposure to colibact…
RT @weldeiry: Geographic and age variations in mutational processes in colorectal cancer https://t.co/ZqrHRieNyB
Geographic and age variations in mutational processes in colorectal cancer https://t.co/8DXE2mWZaJ
RT @josepereag: Geographic and age-related variations in CRC mutational profiles, suggesting that early-life mutagenic exposure to colibact…
Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/iESMP7D90r
Read ‘Geographic and age variations in mutational processes in colorectal cancer’ from @ucsandiego.bsky.social and @sangerinstitute.bsky.social and their collaborators in @nature.com, here: www.nature.com/articles/s41...
Read ‘Geographic and age variations in mutational processes in colorectal cancer’ from @UCSanDiego and @sangerinstitute and their collaborators in @Nature, here: https://t.co/2K6T585YH6
RT @josepereag: Geographic and age-related variations in CRC mutational profiles, suggesting that early-life mutagenic exposure to colibact…
Geographic and age-related variations in CRC mutational profiles, suggesting that early-life mutagenic exposure to colibactin-producing bacteria may contribute to the rising of #EOCRC. The importance of exploring geographical disparities among #EOCRC. https://t.co/F9iijPZW5B
'Geographic and age variations in mutational processes in colorectal cancer' www.nature.com/articles/s41...
RT @GlobalPHObserv: Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/AQzmCx2U75
Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/AQzmCx2U75
Geographic and age variations in mutational processes in colorectal cancer | Nature www.nature.com/articles/s41...
Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/rPEDoAAAPW
RT @hlcao: Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/wQp9f68b9T
Geographic and age variations in mutational processes in colorectal cancer | Nature https://t.co/wQp9f68b9T
RT @CancerGrand: Find the full paper, "Geographic and age variations in mutational processes in colorectal cancer", led by Ludmil Alexandro…
Geographic and age variations in mutational processes in colorectal cancer www.nature.com/articles/s41...
Geographic and age variations in mutational processes in colorectal cancer https://t.co/ZqrHRieNyB
RT @CancerGrand: Find the full paper, "Geographic and age variations in mutational processes in colorectal cancer", led by Ludmil Alexandro…
RT @CancerGrand: Find the full paper, "Geographic and age variations in mutational processes in colorectal cancer", led by Ludmil Alexandro…
RT @CancerGrand: Find the full paper, "Geographic and age variations in mutational processes in colorectal cancer", led by Ludmil Alexandro…
Find the full paper
Geographic and age variations in mutational processes in colorectal cancer | @Nature https://t.co/luMeKc3cPn
#Geographic and #age #variations in mutational processes in #colorectal #cancer, etidiohnew.blogspot.com/2025/04/geog...
Find the full paper, "Geographic and age variations in mutational processes in colorectal cancer", led by Ludmil Alexandrov @UCSanDiego, here: https://t.co/og8OK3VjWo
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