Publications by authors named "Christopher E Keefer"

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The Comparison of Machine Learning and Mechanistic In Vitro-In Vivo Extrapolation Models for the Prediction of Human Intrinsic Clearance.
Christopher E Keefer, George Chang, Li Di, Nathaniel A Woody, David A Tess

Mol Pharm· November 2023

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In-Silico Extraction of Design Ideas Using MMPA-by-QSAR and its Application on ADME Endpoints.
Alexios Koutsoukas, George Chang, Christopher E Keefer

J Chem Inf Model· January 2019

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In Silico Absorption, Distribution, Metabolism, Excretion, and Pharmacokinetics (ADME-PK): Utility and Best Practices. An Industry Perspective from the International Consortium for Innovation through Quality in Pharmaceutical Development.
Franco Lombardo, Prashant V Desai, Rieko Arimoto, Kelly E Desino, Holger Fischer, Christopher E Keefer

J Med Chem· November 2017

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The use of matched molecular series networks for cross target structure activity relationship translation and potency prediction.
Christopher E Keefer, George Chang

Medchemcomm· November 2017

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A multi-endpoint matched molecular pair (MMP) analysis of 6-membered heterocycles.
George Chang, Kim Huard, Gregory W Kauffman, Antonia F Stepan, Christopher E Keefer

Bioorg Med Chem· January 2017

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Evaluating the differences in cycloalkyl ether metabolism using the design parameter "lipophilic metabolism efficiency" (LipMetE) and a matched molecular pairs analysis.
Antonia F Stepan, Gregory W Kauffman, Christopher E Keefer, Patrick R Verhoest, Martin Edwards

J Med Chem· September 2013

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Interpretable, probability-based confidence metric for continuous quantitative structure-activity relationship models.
Christopher E Keefer, Gregory W Kauffman, Rishi Raj Gupta

J Chem Inf Model· February 2013

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Systematic and pairwise analysis of the effects of aromatic halogenation and trifluoromethyl substitution on human liver microsomal clearance.
Hao Sun, Christopher E Keefer, Dennis O Scott

Drug Metab Lett· December 2011

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Extraction of tacit knowledge from large ADME data sets via pairwise analysis.
Christopher E Keefer, George Chang, Gregory W Kauffman

Bioorg Med Chem· June 2011

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