Publications by authors named "Christopher Goldring"

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Targeting the tumor microenvironment in cholangiocarcinoma to improve immune checkpoint blockade: potential strategies and translational pre-clinical models.
Maria-Danae Jessel, Owen McGreevy, Lauryn McReynolds, Lekh N Dahal, Timothy Gilbert, Christopher E Goldring

Clin Transl Immunology· October 2025

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Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety.
Christopher E Goldring, Giusy Russomanno, Carmen Pin, Panuwat Trairatphisan, Kylie A Beattie

Nat Rev Drug Discov· October 2025

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A Preclinical Model of Human Liver Using Precision Cut Tissue Slice Culture.
Owen McGreevy, Timothy Gilbert, Maria-Danae Jessel, Mohammed Bosakhar, Stephen Fenwick, Christopher Goldring

F1000Res· August 2025

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Construction and Expression of Fc-FGF21 by Different Expression Systems and Comparison of Their Similarity and Difference with Efruxifermin by In Vitro and In Vivo Studies.
Xujia Wang, Qin Meng, Aijuan Jia, Yuehua Zhou, Dandan Song, Christopher Goldring

Appl Biochem Biotechnol· April 2025

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Response to "Acetaminophen should be a critical reference hepatotoxin for evaluating human-relevant in vitro models".
Lucia A Livoti, Rowena Sison-Young, Dennis Reddyhoff, Ciarán P Fisher, Iain Gardner, Christopher E Goldring

Toxicol Sci· April 2025

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The importance of preclinical models in cholangiocarcinoma.
Owen McGreevy, Mohammed Bosakhar, Timothy Gilbert, Marc Quinn, Stephen Fenwick, Christopher Goldring

Eur J Surg Oncol· February 2025

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Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models.
Lucia A Livoti, Rowena Sison-Young, Dennis Reddyhoff, Ciarán P Fisher, Iain Gardner, Christopher E Goldring

Toxicol Sci· January 2025

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A systems approach reveals species differences in hepatic stress response capacity.
Giusy Russomanno, Rowena Sison-Young, Lucia A Livoti, Hannah Coghlan, Rosalind E Jenkins, Christopher E Goldring

Toxicol Sci· October 2023

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Study design for development of novel safety biomarkers of drug-induced liver injury by the translational safety biomarker pipeline (TransBioLine) consortium: a study protocol for a nested case-control study.
Jane I Grove, Camilla Stephens, M Isabel Lucena, Raúl J Andrade, Sabine Weber, Christopher E P Goldring

Diagn Progn Res· September 2023

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Analysis of serum microRNA-122 in a randomized controlled trial of N-acetylcysteine for treatment of antituberculosis drug-induced liver injury.
Muhammed Shiraz Moosa, Giusy Russomanno, Jeffrey R Dorfman, Hannah Gunter, Chandni Patel, Christopher Goldring

Br J Clin Pharmacol· June 2023

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Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System.
Serat-E Ali, Xiaoli Meng, Laila Kafu, Sean Hammond, Qing Zhao, Christopher Goldring

Chem Res Toxicol· March 2023

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VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells.
Anil Kumar Mondru, Mohammad A Aljasir, Ahmed Alrumayh, Gopika N Nithianandarajah, Katie Ahmed, Christopher E P Goldring

Cells· March 2023

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Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity.
Ahmed Ghallab, Reham Hassan, Ute Hofmann, Adrian Friebel, Zaynab Hobloss, Christopher Goldring

J Hepatol· July 2022

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A MicroRNA Next-Generation-Sequencing Discovery Assay (miND) for Genome-Scale Analysis and Absolute Quantitation of Circulating MicroRNA Biomarkers.
Kseniya Khamina, Andreas B Diendorfer, Susanna Skalicky, Moritz Weigl, Marianne Pultar, Christopher E Goldring

Int J Mol Sci· January 2022

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The application of cytokeratin-18 as a biomarker for drug-induced liver injury.
Samantha Korver, Joanne Bowen, Kara Pearson, Raymond J Gonzalez, Neil French, Christopher Goldring

Arch Toxicol· November 2021

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Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration.
Benjamin K Y Chan, Mohamed Elmasry, Shiva S Forootan, Giusy Russomanno, Tobias M Bunday, Christopher E Goldring

Hepatology· August 2021

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Gene Signatures Reduce the Stress of Preclinical Drug Hepatotoxicity Screening.
Ian M Copple, B Kevin Park, Christopher E Goldring

Hepatology· July 2021

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Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification.
Lawrence Howell, Rosalind E Jenkins, Stephen Lynch, Carrie Duckworth, B Kevin Park, Christopher Goldring

Arch Toxicol· July 2021

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Current Perspective: 3D Spheroid Models Utilizing Human-Based Cells for Investigating Metabolism-Dependent Drug-Induced Liver Injury.
Christopher R Cox, Stephen Lynch, Christopher Goldring, Parveen Sharma

Front Med Technol· November 2020

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Safety perspectives on presently considered drugs for the treatment of COVID-19.
Sophie L Penman, Robyn T Kiy, Rebecca L Jensen, Christopher Beoku-Betts, Ana Alfirevic, Christopher E Goldring

Br J Pharmacol· October 2020

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Critical considerations for targeting colorectal liver metastases with nanotechnology.
Usman Arshad, Paul A Sutton, Marianne B Ashford, Kevin E Treacher, Neill J Liptrott, Christopher E Goldring

Wiley Interdiscip Rev Nanomed Nanobiotechnol· March 2020

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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Richard J Weaver, Eric A Blomme, Amy E Chadwick, Ian M Copple, Helga H J Gerets, Christopher E Goldring

Nat Rev Drug Discov· February 2020

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Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research.
Jonathan P Evans, Boleslaw K Winiarski, Paul A Sutton, Lorenzo Ressel, Carrie A Duckworth, Christopher E Goldring

Lab Anim· December 2019

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Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.
Jonathan P Evans, Boleslaw K Winiarski, Paul A Sutton, Robert P Jones, Lorenzo Ressel, Christopher E Goldring

Oncotarget· January 2019

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Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop.
Glyn Stacey, Peter Andrews, Curtis Asante, Ivana Barbaric, Jaqueline Barry, Christopher Goldring

Regen Med· December 2018

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