Publications by authors named "Christopher Heim"

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Enhancing Solubility in VHL-Based PROTACs: Optimized USP7 Degraders for Improved Developability.
Sophie Wittenburg, Maximilian R Zuleeg, Kirsten Peter, Patricia Lemnitzer, Rabea Voget, Christopher Heim

J Med Chem· August 2025

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Healthy working in inclusive companies - a study protocol of the GAIN project.
Fabian Holzgreve, Bettina Bredereck, Christopher Heim, Britta Weber, Rolf Ellegast

J Occup Med Toxicol· December 2023

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Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
Christian Steinebach, Aleša Bricelj, Arunima Murgai, Izidor Sosič, Luca Bischof, Christopher Heim

J Med Chem· November 2023

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Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design.
Robert Kuchta, Christopher Heim, Alexander Herrmann, Samuel Maiwald, Yuen Lam Dora Ng

RSC Chem Biol· March 2023

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Cereblon neo-substrate binding mimics the recognition of the cyclic imide degron.
Christopher Heim, Anna-Katharina Spring, Sören Kirchgäßner, Dirk Schwarzer, Marcus D Hartmann

Biochem Biophys Res Commun· February 2023

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Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines.
Mikhail Krasavin, Maria Adamchik, Andrey Bubyrev, Christopher Heim, Samuel Maiwald

Eur J Med Chem· January 2023

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Replacing the phthalimide core in thalidomide with benzotriazole.
Mikhail Krasavin, Andrey Bubyrev, Alexander Kazantsev, Christopher Heim, Samuel Maiwald

J Enzyme Inhib Med Chem· December 2022

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Identification and structural basis of C-terminal cyclic imides as natural degrons for cereblon.
Christopher Heim, Anna-Katharina Spring, Sören Kirchgäßner, Dirk Schwarzer, Marcus D Hartmann

Biochem Biophys Res Commun· December 2022

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PotN represents a novel energy-state sensing PII subfamily, occurring in firmicutes.
Zalina I Iskhakova, Darya E Zhuravleva, Christopher Heim, Marcus D Hartmann, Aleksandr V Laykov

FEBS J· September 2022

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Basic Motor Competencies of 6- to 8-Year-Old Primary School Children in 10 European Countries: A Cross-Sectional Study on Associations With Age, Sex, Body Mass Index, and Physical Activity.
Marina Wälti, Jeffrey Sallen, Manolis Adamakis, Fabienne Ennigkeit, Erin Gerlach, Christopher Heim

Front Psychol· April 2022

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High-resolution structures of the bound effectors avadomide (CC-122) and iberdomide (CC-220) highlight advantages and limitations of the MsCI4 soaking system.
Christopher Heim, Marcus D Hartmann

Acta Crystallogr D Struct Biol· March 2022

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Correction to "Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay".
Samuel Maiwald, Christopher Heim, Birte Hernandez Alvarez, Marcus D Hartmann

ACS Med Chem Lett· January 2022

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On the correlation of cereblon binding, fluorination and antiangiogenic properties of immunomodulatory drugs.
Christopher Heim, Samuel Maiwald, Christian Steinebach, Matthew K Collins, Jonathan Strope

Biochem Biophys Res Commun· January 2021

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Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay.
Samuel Maiwald, Christopher Heim, Birte Hernandez Alvarez, Marcus D Hartmann

ACS Med Chem Lett· January 2021

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De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives.
Christopher Heim, Dimanthi Pliatsika, Farnoush Mousavizadeh, Kerstin Bär, Birte Hernandez Alvarez

J Med Chem· July 2019

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Construct and correlates of basic motor competencies in primary school-aged children.
Christian Herrmann, Christopher Heim, Harald Seelig

J Sport Health Sci· January 2019

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Design-Considerations regarding Silicon/Graphite and Tin/Graphite Composite Electrodes for Lithium-Ion Batteries.
Manuel Otero, Christopher Heim, Ezequiel P M Leiva, Norbert Wagner, Andreas Friedrich

Sci Rep· October 2018

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Chemical Ligand Space of Cereblon.
Iuliia Boichenko, Kerstin Bär, Silvia Deiss, Christopher Heim, Reinhard Albrecht

ACS Omega· September 2018

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Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G.
Steffen Eipper, Robin Steiner, Adam Lesner, Marcin Sienczyk, David Palesch, Christopher Heim

PLoS One· August 2016

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The risk of involuntary firearms discharge.
Christopher Heim, Dietmar Schmidtbleicher, Eckhard Niebergall

Hum Factors· December 2006

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