Publications by authors named "Christopher Hellen"

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Structural Studies of Nedicistrovirus IRES-Driven, Initiation Factor-independent Translation Shed Light on Key Steps of Eukaryotic Translation Elongation.
Swastik De, Clara G Altomare, Irina S Abaeva, Prikshat Dadhwal, Priyanka Garg, Christopher U T Hellen

bioRxiv· September 2025

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The translation initiation factor DHX29 appears to pull on mRNA in a direction opposite to scanning.
Da Cui, Tatyana Pestova, Christopher Hellen, Amedee des Georges

bioRxiv· July 2025

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The mechanism of ribosomal recruitment during translation initiation on Type 2 IRESs.
Sayan Bhattacharjee, Irina S Abaeva, Zuben P Brown, Yani Arhab, Hengameh Fallah, Christopher U T Hellen

bioRxiv· June 2025

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Inconsistencies in the published rabbit ribosomal rRNAs: a proposal for uniformity in sequence and site numbering.
Swastik De, Michelle Zhou, Zuben P Brown, Raymond N Burton-Smith, Yaser Hashem, Christopher U T Hellen

RNA· May 2025

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The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin.
Irina S Abaeva, Alexander G Bulakhov, Christopher U T Hellen, Tatyana V Pestova

Genes Dev· May 2025

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Viral Strategies and Cellular Countermeasures That Regulate mRNA Access to the Translation Apparatus.
Christopher U T Hellen

Viruses· May 2025

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Superkiller complex problems expose a cancer-cell vulnerability.
Christopher U T Hellen, Tatyana V Pestova

Nature· February 2025

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Inconsistencies in the published rabbit ribosomal rRNAs: a proposal for uniformity in sequence and site numbering.
Swastik De, Michelle Zhou, Zuben P Brown, Raymond N Burton-Smith, Yaser Hashem, Christopher U T Hellen

bioRxiv· October 2024

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The ribosome-associated quality control factor TCF25 imposes K48 specificity on Listerin-mediated ubiquitination of nascent chains by binding and specifically orienting the acceptor ubiquitin.
Irina S Abaeva, Alexander G Bulakhov, Christopher U T Hellen, Tatyana V Pestova

bioRxiv· October 2024

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Translation of Overlapping Open Reading Frames Promoted by Type 2 IRESs in Avian Calicivirus Genomes.
Yani Arhab, Tatyana V Pestova, Christopher U T Hellen

Viruses· September 2024

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Ribosomal collision is not a prerequisite for ZNF598-mediated ribosome ubiquitination and disassembly of ribosomal complexes by ASCC.
Anna Miścicka, Alexander G Bulakhov, Kazushige Kuroha, Alexandra Zinoviev, Christopher U T Hellen

Nucleic Acids Res· May 2024

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Genetic mechanisms underlying the structural elaboration and dissemination of viral internal ribosomal entry sites.
Irina S Abaeva, Tatyana V Pestova, Christopher U T Hellen

bioRxiv· April 2024

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The structure and mechanism of action of a distinct class of dicistrovirus intergenic region IRESs.
Irina S Abaeva, Christina Young, Reid Warsaba, Nadiyah Khan, Lan Vy Tran, Christopher U T Hellen

Nucleic Acids Res· September 2023

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In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g.
Irina S Abaeva, Yani Arhab, Anna Miścicka, Christopher U T Hellen, Tatyana V Pestova

Genes Dev· September 2023

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Initiation of translation on nedicistrovirus and related intergenic region IRESs by their factor-independent binding to the P site of 80S ribosomes.
Anna Miścicka, Kristen Lu, Irina S Abaeva, Tatyana V Pestova, Christopher U T Hellen

RNA· July 2023

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reconstitution of SARS CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g.
Irina S Abaeva, Yani Arhab, Anna Miścicka, Christopher U T Hellen, Tatyana V Pestova

bioRxiv· May 2023

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Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
Zuben P Brown, Irina S Abaeva, Swastik De, Christopher U T Hellen, Tatyana V Pestova

EMBO J· August 2022

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Horizontal gene transfer as a mechanism for the promiscuous acquisition of distinct classes of IRES by avian caliciviruses.
Yani Arhab, Anna Miścicka, Tatyana V Pestova, Christopher U T Hellen

Nucleic Acids Res· January 2022

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Functional role and ribosomal position of the unique N-terminal region of DHX29, a factor required for initiation on structured mammalian mRNAs.
Trevor R Sweeney, Vidya Dhote, Ewelina Guca, Christopher U T Hellen, Yaser Hashem

Nucleic Acids Res· December 2021

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A translation enhancer element from black beetle virus engages yeast eIF4G1 to drive cap-independent translation initiation.
Brandon M Trainor, Arnab Ghosh, Dimitri G Pestov, Christopher U T Hellen, Natalia Shcherbik

Sci Rep· January 2021

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In Vitro Characterization of the Activity of the Mammalian RNA Exosome on mRNAs in Ribosomal Translation Complexes.
Alexandra Zinoviev, Christopher U T Hellen, Tatyana V Pestova

Methods Mol Biol· December 2020

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The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism.
Irina S Abaeva, Quentin Vicens, Anthony Bochler, Heddy Soufari, Angelita Simonetti, Christopher U T Hellen

Cell Rep· December 2020

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Dissemination of Internal Ribosomal Entry Sites (IRES) Between Viruses by Horizontal Gene Transfer.
Yani Arhab, Alexander G Bulakhov, Tatyana V Pestova, Christopher U T Hellen

Viruses· June 2020

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Extraction of mRNA from Stalled Ribosomes by the Ski Complex.
Alexandra Zinoviev, Rustam K Ayupov, Irina S Abaeva, Christopher U T Hellen, Tatyana V Pestova

Mol Cell· March 2020

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Two classes of EF1-family translational GTPases encoded by giant viruses.
Alexandra Zinoviev, Kazushige Kuroha, Tatyana V Pestova, Christopher U T Hellen

Nucleic Acids Res· June 2019

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