Publications by authors named "Christopher Huston"

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Organoid-based system and reporter for the study of sexual reproduction.
Bethany R Korwin-Mihavics, Emmett A Dews, Peter Miller, Alexandra Cameron, Bruno Martorelli di Genova, Christopher D Huston

Microbiol Spectr· August 2025

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A propidium iodide-based screen of the "Bug Box" against reveals potent inhibitors.
Emmett A Dews, José E Teixeira, Christopher D Huston, Marvin J Meyers, Peter R Hyson

Antimicrob Agents Chemother· July 2025

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Organoid-based system and reporter for the study of sexual reproduction.
Bethany R Korwin-Mihavics, Emmett A Dews, Peter Miller, Alexandra Cameron, Bruno Martorelli di Genova, Christopher D Huston

bioRxiv· February 2025

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Discovery of an Orally Efficacious Pyrazolo[3,4-]pyrimidine Benzoxaborole as a Potent Inhibitor of .
Makafui Gasonoo, Soumitra Guin, José E Teixeira, Edmund Oboh, Anusha Gokanapalle, Christopher D Huston

J Med Chem· January 2025

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lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy.
Nicola Caldwell, Caroline Peet, Peter Miller, Beatrice L Colon, Malcolm G Taylor, Christopher D Huston

Sci Transl Med· October 2024

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Identification of potent and orally efficacious phosphodiesterase inhibitors in Cryptosporidium parvum-infected immunocompromised male mice.
Jubilee Ajiboye, José E Teixeira, Makafui Gasonoo, Ethan B Mattice, Bethany Korwin-Mihavics, Christopher D Huston

Nat Commun· September 2024

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Cryptosporidium life cycle small molecule probing implicates translational repression and an Apetala 2 transcription factor in macrogamont differentiation.
Muhammad M Hasan, Ethan B Mattice, José E Teixeira, Rajiv S Jumani, Erin E Stebbins, Christopher D Huston

PLoS Pathog· April 2024

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Whole-genome sequencing of carbapenem-resistant Enterobacterales isolates in southeast Louisiana reveals persistent genetic clusters spanning multiple locations.
Rebecca Rose, Amy Feehan, Benjamin N Lain, Deborah Ashcraft, David J Nolan, Christopher Huston

J Infect Public Health· December 2023

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Comparing antimicrobial resistant genes and phenotypes across multiple sequencing platforms and assays for Enterobacterales clinical isolates.
Rebecca Rose, David J Nolan, Deborah Ashcraft, Amy K Feehan, Leonor Velez-Climent, Christopher Huston

BMC Microbiol· August 2023

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Structure-Activity Relationship Studies of the Aryl Acetamide Triazolopyridazines against Reveals Remarkable Role of Fluorine.
Tanner J Schubert, Edmund Oboh, Hannah Peek, Emily Philo, José E Teixeira, Christopher D Huston

J Med Chem· June 2023

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Structure-Activity relationships of replacements for the triazolopyridazine of Anti-Cryptosporidium lead SLU-2633.
Edmund Oboh, José E Teixeira, Tanner J Schubert, Adriana S Maribona, Brylon N Denman, Christopher D Huston

Bioorg Med Chem· May 2023

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SARS-CoV-2 genomic surveillance as an evidence-based infection control approach in an offshore petroleum employee population.
Susanna L Lamers, David J Nolan, Tessa M LaFleur, Benjamin N Lain, Samual R Moot, Christopher R Huston

Am J Infect Control· September 2022

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Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin.
Edmund Oboh, Tanner J Schubert, Jose E Teixeira, Erin E Stebbins, Peter Miller, Christopher D Huston

J Med Chem· August 2021

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The Clofazimine for Treatment of Cryptosporidiosis in HIV-Infected Adults (CRYPTOFAZ) and Lessons Learned for Anticryptosporidial Drug Development.
Christopher D Huston

Clin Infect Dis· July 2021

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Spontaneous Selection of Drug Resistance in a Calf Model of Infection.
Muhammad M Hasan, Erin E Stebbins, Robert K M Choy, J Robert Gillespie, Eugenio L de Hostos, Christopher D Huston

Antimicrob Agents Chemother· May 2021

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Impact and costs of a hepatitis C virus screening programme for adults hospitalised at an academic medical centre.
Timothy J Whitman, Cindy D Noyes, Andrew J Hale, Devika Singh, Stephen G DeVoe, Christopher D Huston

BMJ Open Qual· February 2021

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Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction step.
Emily A Bruce, Meei-Li Huang, Garrett A Perchetti, Scott Tighe, Pheobe Laaguiby, Christopher D Huston

PLoS Biol· October 2020

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A Veterinarian From Vermont Presenting With a Painful Right Index Finger Following a Needlestick Injury That Occurred While Caring for a Dog.
Prateek Ghatage, Kristen K Pierce, Christina Wojewoda, Nicole Mendelson, Jonathan Wilcock, Christopher D Huston

Clin Infect Dis· September 2020

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Bicyclic azetidines kill the diarrheal pathogen in mice by inhibiting parasite phenylalanyl-tRNA synthetase.
Sumiti Vinayak, Rajiv S Jumani, Peter Miller, Muhammad M Hasan, Briana I McLeod, Christopher D Huston

Sci Transl Med· September 2020

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Coactosin Phosphorylation Controls Entamoeba histolytica Cell Membrane Protrusions and Cell Motility.
Muhammad M Hasan, José E Teixeira, Ying-Wai Lam, Christopher D Huston

mBio· August 2020

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Cryptosporidiosis should be designated as a tropical disease by the US Food and Drug Administration.
Robert K M Choy, Christopher D Huston

PLoS Negl Trop Dis· July 2020

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DIRECT RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWABS WITHOUT AN RNA EXTRACTION STEP.
Emily A Bruce, Meei-Li Huang, Garrett A Perchetti, Scott Tighe, Pheobe Laaguiby, Christopher D Huston

bioRxiv· April 2020

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Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity.
Gretchen Ehrenkaufer, Pengyang Li, Erin E Stebbins, Monica M Kangussu-Marcolino, Anjan Debnath, Christopher D Huston

PLoS Negl Trop Dis· March 2020

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Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis.
Christopher S Lunde, Erin E Stebbins, Rajiv S Jumani, Md Mahmudul Hasan, Peter Miller, Christopher D Huston

Nat Commun· June 2019

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A suite of phenotypic assays to ensure pipeline diversity when prioritizing drug-like Cryptosporidium growth inhibitors.
Rajiv S Jumani, Muhammad M Hasan, Erin E Stebbins, Liam Donnelly, Peter Miller, Christopher D Huston

Nat Commun· April 2019

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