Publications by authors named "Christopher J Ott"

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p300/CBP is an essential driver of pathogenic enhancer activity and gene expression in Ewing sarcoma.
Laura C Godfrey, Brandon Regalado, Sydney R Schweber, Charles Hatton, Daniela V Wenge, Christopher J Ott, Scott A Armstrong

EMBO Rep· October 2025

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ID2 suppresses multiple myeloma cell proliferation by repressing the activity of the transcription factor TCF3.
Mariateresa Fulciniti, Yao Yao, Tommaso Perini, Jessica Fong Ng, Anaïs Schavgoulidze, Christopher J Ott

Blood Cancer Discov· October 2025

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Targeting Monounsaturated Fatty Acid Metabolism for Radiosensitization of KRAS Mutant 3D Lung Cancer Models.
Shan Lu, Xiao Pan, Eva Volckova, Anjali Shinde, Schuyler R Fuller, Christopher J Ott

Mol Cancer Ther· June 2025

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Development of p300-targeting degraders with enhanced selectivity and onset of degradation.
Graham P Marsh, Mark S Cooper, Sean Goggins, Stephen J Reynolds, Dean F Wheeler, Christopher J Ott

RSC Med Chem· May 2025

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Oxidation of retromer complex controls mitochondrial translation.
Junbing Zhang, Md Yousuf Ali, Harrison Byron Chong, Pei-Chieh Tien, James Woods, Christopher J Ott

Nature· May 2025

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Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse.
Anthony K Edmonds, Dimitrios-Ilias Balourdas, Graham P Marsh, Robert Felix, Bradley Brasher, Christopher J Ott

J Med Chem· May 2025

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Targeted degradation of CDK9 potently disrupts the MYC-regulated network.
Mohammed A Toure, Keisuke Motoyama, Yichen Xiang, Julie Urgiles, Florian Kabinger, Christopher J Ott

Cell Chem Biol· April 2025

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Correction: DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming.
Ilaria Gritti, Jinkai Wan, Vajira Weeresekara, Joel M Vaz, Giuseppe Tarantino, Christopher J Ott

Cancer Discov· April 2025

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DNAJB1-PRKACA Fusion Drives Fibrolamellar Liver Cancer through Impaired SIK Signaling and CRTC2/p300-Mediated Transcriptional Reprogramming.
Ilaria Gritti, Jinkai Wan, Vajira Weeresekara, Joel M Vaz, Giuseppe Tarantino, Christopher J Ott

Cancer Discov· February 2025

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DrugMap: A quantitative pan-cancer analysis of cysteine ligandability.
Mariko Takahashi, Harrison B Chong, Siwen Zhang, Tzu-Yi Yang, Matthew J Lazarov, Christopher J Ott

Cell· May 2024

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Targeted Degradation of CDK9 Potently Disrupts the MYC Transcriptional Network.
Mohammed A Toure, Keisuke Motoyama, Yichen Xiang, Julie Urgiles, Florian Kabinger, Christopher J Ott

bioRxiv· May 2024

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Exploration of bromodomain ligand-linker conjugation sites for efficient CBP/p300 heterobifunctional degrader activity.
Praveen Kumar Tiwari, Sai Reddy Doda, Raghu Vannam, Manish Hudlikar, Drew A Harrison, Christopher J Ott

Bioorg Med Chem Lett· April 2024

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CIC-DUX4 Chromatin Profiling Reveals New Epigenetic Dependencies and Actionable Therapeutic Targets in CIC-Rearranged Sarcomas.
Arnaud Bakaric, Luisa Cironi, Viviane Praz, Rajendran Sanalkumar, Liliane C Broye, Christopher J Ott

Cancers (Basel)· January 2024

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Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition.
Timothy R Bishop, Chitra Subramanian, Eric M Bilotta, Leopold Garnar-Wortzel, Anissa R Ramos, Christopher J Ott

Nat Chem Biol· October 2023

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Therapy-induced APOBEC3A drives evolution of persistent cancer cells.
Hideko Isozaki, Ramin Sakhtemani, Ammal Abbasi, Naveed Nikpour, Marcello Stanzione, Christopher J Ott

Nature· August 2023

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Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities.
Yuxiang Zhang, David Remillard, Ugoma Onubogu, Barbara Karakyriakou, Joshua N Asiaban, Christopher J Ott

Nat Struct Mol Biol· August 2023

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Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias.
Ricardo de Matos Simoes, Ryosuke Shirasaki, Sondra L Downey-Kopyscinski, Geoffrey M Matthews, Benjamin G Barwick, Christopher J Ott

Nat Cancer· May 2023

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Screening and Validation of Molecular Targeted Radiosensitizers.
Henning Willers, Xiao Pan, Nathalie Borgeaud, Irina Korovina, Lydia Koi, Christopher J Ott

Int J Radiat Oncol Biol Phys· December 2021

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Selective targeting of MYC mRNA by stabilized antisense oligonucleotides.
Taylor Gill, Haichuan Wang, Raj Bandaru, Matthew Lawlor, Chenyue Lu, Christopher J Ott

Oncogene· November 2021

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BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia.
Weimin Kong, Alexander Dimitri, Wenliang Wang, In-Young Jung, Christopher J Ott

J Clin Invest· August 2021

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Targeted degradation of the enhancer lysine acetyltransferases CBP and p300.
Raghu Vannam, Jan Sayilgan, Samuel Ojeda, Barbara Karakyriakou, Eileen Hu, Christopher J Ott

Cell Chem Biol· April 2021

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A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation.
Gregory Lazarian, Shanye Yin, Elisa Ten Hacken, Tomasz Sewastianik, Mohamed Uduman, Christopher J Ott

Cancer Cell· March 2021

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Targeting oncoproteins with a positive selection assay for protein degraders.
Vidyasagar Koduri, Leslie Duplaquet, Benjamin L Lampson, Adam C Wang, Amin H Sabet, Christopher J Ott

Sci Adv· February 2021

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Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins.
Ryosuke Shirasaki, Geoffrey M Matthews, Sara Gandolfi, Ricardo de Matos Simoes, Dennis L Buckley, Christopher J Ott

Cell Rep· January 2021

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Circles with a Point: New Insights into Oncogenic Extrachromosomal DNA.
Christopher J Ott

Cancer Cell· February 2020

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