Publications by authors named "Christopher Matheny"

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Manufacturing-dependent change in biological activity of the TLR4 agonist GSK1795091 and implications for lipid A analog development.
Neeltje Steeghs, Aaron R Hansen, Glenn J Hanna, Elena Garralda, Haeseong Park, Christopher Matheny

Clin Transl Sci· November 2022

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A Phase I, First-in-Human Study of GSK2849330, an Anti-HER3 Monoclonal Antibody, in HER3-Expressing Solid Tumors.
Hui K Gan, Michael Millward, Mathilde Jalving, Ignacio Garrido-Laguna, Jason D Lickliter, Christopher Matheny

Oncologist· October 2021

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Safety, Pharmacokinetics, and Pharmacodynamics of the TLR4 Agonist GSK1795091 in Healthy Individuals: Results from a Randomized, Double-blind, Placebo-controlled, Ascending Dose Study.
Bruce A Hug, Christopher J Matheny, Olivia Burns, Herbert Struemper, Xiaowei Wang

Clin Ther· August 2020

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Response to ERBB3-Directed Targeted Therapy in -Rearranged Cancers.
Alexander Drilon, Romel Somwar, Biju P Mangatt, Henrik Edgren, Patrice Desmeules, Christopher Matheny

Cancer Discov· June 2018

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Non invasive imaging assessment of the biodistribution of GSK2849330, an ADCC and CDC optimized anti HER3 mAb, and its role in tumor macrophage recruitment in human tumor-bearing mice.
Hasan Alsaid, Tinamarie Skedzielewski, Mary V Rambo, Kristen Hunsinger, Bao Hoang, Christopher Matheny

PLoS One· September 2017

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Inhibition of Intestinal OATP2B1 by the Calcium Receptor Antagonist Ronacaleret Results in a Significant Drug-Drug Interaction by Causing a 2-Fold Decrease in Exposure of Rosuvastatin.
Marta Johnson, Dipal Patel, Christopher Matheny, May Ho, Liangfu Chen

Drug Metab Dispos· January 2017

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Optimizing the in vitro and clinical assessment of drug interaction risk by understanding co-medications in patient populations.
Jackie Bloomer, Geo Derimanov, Etienne Dumont, Harma Ellens, Christopher Matheny

Expert Opin Drug Metab Toxicol· June 2013

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An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation.
Sanjay Kumar, Christopher J Matheny, Sandra J Hoffman, Robert W Marquis, Maggie Schultz

Bone· February 2010

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Effect of prototypical inducing agents on P-glycoprotein and CYP3A expression in mouse tissues.
Christopher J Matheny, Rabia Y Ali, Xiaodong Yang, Gary M Pollack

Drug Metab Dispos· September 2004

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