Publications by authors named "Christopher Moertel"

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Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumors.
Kyle B Williams, Alex T Larsson, Bryant J Keller, Katherine E Chaney, Rory L Williams, Christopher L Moertel

Mol Cancer Ther· October 2025

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Reply to: Challenges in Assessing Response in Clinical Trials for Neurofibromatosis Type 1 Plexiform Neurofibromas.
Christopher L Moertel, Angela C Hirbe, Laura J Klesse, P Leia Nghiemphu, Dusica Babovic-Vuksanovic

J Clin Oncol· May 2025

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ReNeu: A Pivotal, Phase IIb Trial of Mirdametinib in Adults and Children With Symptomatic Neurofibromatosis Type 1-Associated Plexiform Neurofibroma.
Christopher L Moertel, Angela C Hirbe, Hans H Shuhaiber, Kevin Bielamowicz, Alpa Sidhu

J Clin Oncol· February 2025

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Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions.
Audrey-Anne Lamoureux, Michael J Fisher, Lauriane Lemelle, Elke Pfaff, Pouneh Amir-Yazdani, Christopher L Moertel

Clin Cancer Res· February 2025

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Pharmacogenomic synthetic lethal screens reveal hidden vulnerabilities and new therapeutic approaches for treatment of NF1-associated tumors.
Kyle B Williams, Alex T Larsson, Bryant J Keller, Katherine E Chaney, Rory L Williams, Christopher L Moertel

bioRxiv· November 2024

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CD200 depletion in glioma enhances antitumor immunity and induces tumor rejection.
Itay Raphael, Anzar A Mujeeb, Elisabet Ampudia-Mesias, ReidAnn E Sever, Brandon McClellan, Christopher L Moertel

bioRxiv· September 2024

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The 8th International RASopathies Symposium: Expanding research and care practice through global collaboration and advocacy.
Elizabeth I Pierpont, Anton M Bennett, Lisa Schoyer, Beth Stronach, April Anschutz, Christopher Moertel

Am J Med Genet A· April 2024

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The Gene Induces Tumor Growth and Triggers Leptomeningeal Metastasis by Regulating the mTORC2 Signaling Pathway in Group 3 Medulloblastomas.
Elisabet Ampudia-Mesias, Charles S Cameron, Eunjae Yoo, Marcus Kelly, Sarah M Anderson, Christopher L Moertel

Int J Mol Sci· April 2024

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A core outcome domain set to assess cutaneous neurofibromas related to neurofibromatosis type 1 in clinical trials.
Laura Fertitta, Christina Bergqvist, Kavita Y Sarin, Scott R Plotkin, Christopher Moertel

Br J Dermatol· January 2024

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Perinatal folate levels do not influence tumor latency or multiplicity in a model of NF1 associated plexiform-like neurofibromas.
Kyle B Williams, Andrew R Marley, Justin Tibbitts, Christopher L Moertel, Kimberly J Johnson

BMC Res Notes· October 2023

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Combining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1.
Sara H Osum, Eunice I Oribamise, Stanislas M A S Corbière, Mandy Taisto, Tyler Jubenville, Christopher Moertel

Mol Ther Nucleic Acids· September 2023

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Sex differences in methylation profiles are apparent in medulloblastoma, particularly among SHH tumors.
Rachel M Moss, Natali Sorajja, Lauren J Mills, Christopher L Moertel, Thanh T Hoang

Front Oncol· March 2023

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represents a novel fusion event in pediatric low-grade glioma.
Robert T Galvin, Cynthia Zheng, Garrett Fitzpatrick, Colleen L Forster, Carolina Sandoval-Garcia, Christopher L Moertel

Neurooncol Adv· February 2023

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Efficacy and Safety of Trametinib Monotherapy or in Combination With Dabrafenib in Pediatric V600-Mutant Low-Grade Glioma.
Eric Bouffet, Birgit Geoerger, Christopher Moertel, James A Whitlock, Isabelle Aerts

J Clin Oncol· January 2023

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MEK inhibitors for neurofibromatosis type 1 manifestations: Clinical evidence and consensus.
Peter M K de Blank, Andrea M Gross, Srivandana Akshintala, Jaishri O Blakeley, Gideon Bollag, Christopher Moertel

Neuro Oncol· November 2022

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The Role of Socioeconomic Status and Race/Ethnicity in Malignant Peripheral Nerve Sheath Tumor Survival: A Surveillance, Epidemiology, and End Results-Based Analysis.
Allison M Domingues, Christopher L Moertel, Erin L Marcotte

Cancer Epidemiol Biomarkers Prev· September 2022

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CD200AR-L: mechanism of action and preclinical and clinical insights for treating high-grade brain tumors.
Christopher Moertel, Francisco Martinez-Puerta, Grace G Elizabeth Pluhar, Maria Graciela Castro, Michael Olin

Expert Opin Investig Drugs· September 2022

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Minority children experience a higher risk of death from many central nervous system tumor types even after accounting for treatment received: A National Cancer Database analysis.
Kristin J Moore, Christopher L Moertel, Lindsay A Williams

Cancer· April 2022

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Young adult males have worse survival than females that is largely independent of treatment received for many types of central nervous system tumors: A National Cancer Database analysis.
Kristin J Moore, Christopher L Moertel, Lindsay A Williams

Cancer· April 2022

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Randomized trial of neoadjuvant vaccination with tumor-cell lysate induces T cell response in low-grade gliomas.
Hirokazu Ogino, Jennie W Taylor, Takahide Nejo, David Gibson, Payal B Watchmaker, Christopher L Moertel

J Clin Invest· February 2022

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Maternal Contraceptive Use and Central Nervous System Tumors in Offspring.
Logan G Spector, Christopher L Moertel, H Irene Su

JAMA· January 2022

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Measuring the Effect of Cutaneous Neurofibromas on Quality of Life in Neurofibromatosis Type 1.
Sheilagh Maguiness, Yemima Berman, Nathan Rubin, Melissa Dodds, Scott R Plotkin, Christopher Moertel

Neurology· August 2021

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CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway.
Elisabet Ampudia-Mesias, Francisco Puerta-Martinez, Miurel Bridges, David Zellmer, Andrew Janeiro, Christopher L Moertel

Neurotherapeutics· July 2021

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Correction to: CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway.
Elisabet Ampudia-Mesias, Francisco Puerta-Martinez, Miurel Bridges, David Zellmer, Andrew Janeiro, Christopher L Moertel

Neurotherapeutics· July 2021

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Selumetinib normalizes Ras/MAPK signaling in clinically relevant neurofibromatosis type 1 minipig tissues in vivo.
Sara H Osum, Alexander W Coutts, Dylan J Duerre, Barbara R Tschida, Mark N Kirstein, Christopher L Moertel

Neurooncol Adv· February 2021

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