Publications by authors named "Christopher Negron"

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IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFβ.
Yunhao Tan, Kenta Mosallanejad, Qingxiu Zhang, Stephen O'Brien, Meghan Clements, Christopher Negron

Front Immunol· March 2024

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TransMHCII: a novel MHC-II binding prediction model built using a protein language model and an image classifier.
Xin Yu, Christopher Negron, Lili Huang, Geertruida Veldman

Antib Ther· April 2023

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A novel method for in silico assessment of Methionine oxidation risk in monoclonal antibodies: Improvement over the 2-shell model.
Davide Tavella, David R Ouellette, Raffaella Garofalo, Kai Zhu, Jianwen Xu, Christopher Negron

PLoS One· January 2023

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Separating clinical antibodies from repertoire antibodies, a path to in silico developability assessment.
Christopher Negron, Joyce Fang, Michael J McPherson, W Blaine Stine, Andrew J McCluskey

MAbs· July 2022

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Surface salt bridges contribute to the extreme thermal stability of an FN3-like domain from a thermophilic bacterium.
Lauren Boucher, Sandeep Somani, Christopher Negron, Wenting Ma, Steven Jacobs

Proteins· January 2022

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Large-scale in vitro functional testing and novel variant scoring via protein modeling provide insights into alkaline phosphatase activity in hypophosphatasia.
Guillermo Del Angel, John Reynders, Christopher Negron, Thomas Steinbrecher, Etienne Mornet

Hum Mutat· July 2020

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Predicting mutations deleterious to function in beta-lactamase TEM1 using MM-GBSA.
Christopher Negron, David A Pearlman, Guillermo Del Angel

PLoS One· December 2019

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Relative Binding Affinity Prediction of Charge-Changing Sequence Mutations with FEP in Protein-Protein Interfaces.
Anthony J Clark, Christopher Negron, Kevin Hauser, Mengzhen Sun, Lingle Wang

J Mol Biol· March 2019

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Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations.
Kevin Hauser, Christopher Negron, Steven K Albanese, Soumya Ray, Thomas Steinbrecher

Commun Biol· June 2018

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Predicting the Effect of Amino Acid Single-Point Mutations on Protein Stability-Large-Scale Validation of MD-Based Relative Free Energy Calculations.
Thomas Steinbrecher, Chongkai Zhu, Lingle Wang, Robert Abel, Christopher Negron

J Mol Biol· April 2017

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A set of computationally designed orthogonal antiparallel homodimers that expands the synthetic coiled-coil toolkit.
Christopher Negron, Amy E Keating

J Am Chem Soc· November 2014

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Multistate protein design using CLEVER and CLASSY.
Christopher Negron, Amy E Keating

Methods Enzymol· August 2013

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Manipulating cofactor binding thermodynamics in an artificial oxygen transport protein.
Lei Zhang, J L Ross Anderson, Ismail Ahmed, Jessica A Norman, Christopher Negron

Biochemistry· November 2011

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Design principles for chlorophyll-binding sites in helical proteins.
Paula Braun, Eran Goldberg, Christopher Negron, Mathias von Jan, Fei Xu

Proteins· February 2011

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Geometric constraints for porphyrin binding in helical protein binding sites.
Christopher Negron, Christian Fufezan, Ronald L Koder

Proteins· February 2009

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