Publications by authors named "Christopher Squire"

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Structural remodelling of the 2OG oxygenase Rv3406 enables sulfur-scavenging in .
Vicky Tzu-Jung Juan, Patrick Bajan, Chatchakorn Eurtivong, Tianyang Liu, Christopher J Squire

Chem Commun (Camb)· November 2025

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Interplay between malic enzyme 2, de novo serine synthesis, and the malate-aspartate shuttle drives metabolic adaptation in triple-negative breast cancer.
Jin Heon Jeon, Mark D Slayton, Ben Krinkel, Olamide Animasahun, Ajay Shankaran, Christopher Squire

Cancer Metab· October 2025

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Protease mimicry: Dissecting the ester bond crosslinking mechanics in bacterial adhesin proteins.
Yuliana Yosaatmadja, Vanessa Ung, Xinlu Liu, Yixuan Zhao, Julia K Wardega, Christopher J Squire

Protein Sci· August 2025

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Feedback regulation of iron-sulfur cluster biogenesis.
Stephanie M Stuteley, Jiahua Chen, Jin Wang, Stephanie Dawes, Edward N Baker, Christopher J Squire

bioRxiv· June 2025

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Adjuvant strategies to tackle -mediated polymyxin resistance.
Madison R Nuske, Junlang Zhong, Renjie Huang, Vijayalekshmi Sarojini, Jack L Y Chen, Christopher J Squire

RSC Med Chem· February 2025

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Discovery of a Novel Pseudo-Natural Product Aurora Kinase Inhibitor Chemotype through Morphological Profiling.
Lin Wang, Furkan Yilmaz, Okan Yildirim, Beate Schölermann, Sukdev Bag, Christopher Squire

Adv Sci (Weinh)· June 2024

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Poly-γ-glutamylation of biomolecules.
Ghader Bashiri, Esther M M Bulloch, William R Bramley, Madison Davidson, Stephanie M Stuteley, Christopher J Squire

Nat Commun· February 2024

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A Portable and Disposable Electrochemical Sensor Utilizing Laser-Scribed Graphene for Rapid SARS-CoV-2 Detection.
Runzhong Wang, Bicheng Zhu, Paul Young, Yu Luo, John Taylor, Christopher J Squire

Biosensors (Basel)· December 2023

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Domain structure and cross-linking in a giant adhesin from the Mobiluncus mulieris bacterium.
Paul G Young, Jacob M Paynter, Julia K Wardega, Martin J Middleditch, Leo S Payne, Christopher J Squire

Acta Crystallogr D Struct Biol· November 2023

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Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs.
Euphemia Leung, Jinal Patel, Jennifer A Hollywood, Ayesha Zafar, Petr Tomek, Christopher J Squire

Oncol Ther· December 2021

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Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis.
Jodi L Brewster, Petr Pachl, James L O McKellar, Maria Selmer, Christopher J Squire

J Biol Chem· August 2021

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Molecular Superglues: Discovery and Engineering Orthogonalization.
Paul G Young, Christopher J Squire

Methods Mol Biol· January 2021

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The active site of the branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster.
Ghader Bashiri, Tyler L Grove, Subray S Hegde, Thomas Lagautriere, Gary J Gerfen, Christopher J Squire

J Biol Chem· August 2019

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Rotational Freedom, Steric Hindrance, and Protein Dynamics Explain BLU554 Selectivity for the Hinge Cysteine of FGFR4.
Xiaojing Lin, Yuliana Yosaatmadja, Maria Kalyukina, Martin J Middleditch, Zhen Zhang, Christopher J Squire

ACS Med Chem Lett· August 2019

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Investigations of the key macrolactamisation step in the synthesis of cyclic tetrapeptide pseudoxylallemycin A.
Alan J Cameron, Christopher J Squire, Ashley Gérenton, Louise A Stubbing, Paul W R Harris

Org Biomol Chem· April 2019

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TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure.
Maria Kalyukina, Yuliana Yosaatmadja, Martin J Middleditch, Adam V Patterson, Jeff B Smaill, Christopher J Squire

ChemMedChem· February 2019

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Identification of MRP2 as a targetable factor limiting oxaliplatin accumulation and response in gastrointestinal cancer.
Khine Myint, Riya Biswas, Yan Li, Nancy Jong, Stephen Jamieson, Christopher Squire

Sci Rep· February 2019

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MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance.
Soo Jung Son, Renjie Huang, Christopher J Squire, Ivanhoe K H Leung

Drug Discov Today· January 2019

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Crystal and NMR Structures of a Peptidomimetic β-Turn That Provides Facile Synthesis of 13-Membered Cyclic Tetrapeptides.
Alan J Cameron, Christopher J Squire, Patrick J B Edwards, Elena Harjes, Vijayalekshmi Sarojini

Chem Asian J· December 2017

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2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors.
Xueqiang Li, Christopher P Guise, Rana Taghipouran, Yuliana Yosaatmadja, Amir Ashoorzadeh, Christopher J Squire

Eur J Med Chem· July 2017

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Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B.
Sandhya Badrinarayanan, Christopher J Squire, Jonathan Sperry, Margaret A Brimble

Org Lett· July 2017

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Engineering a Lys-Asn isopeptide bond into an immunoglobulin-like protein domain enhances its stability.
Hanna Kwon, Paul G Young, Christopher J Squire, Edward N Baker

Sci Rep· February 2017

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Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes.
Valerie W C Soo, Yuliana Yosaatmadja, Christopher J Squire, Wayne M Patrick

J Biol Chem· September 2016

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Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily.
Ho Yeung, Christopher J Squire, Yuliana Yosaatmadja, Santosh Panjikar, Gemma López

Angew Chem Int Ed Engl· July 2016

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Elongation of the Poly-γ-glutamate Tail of F420 Requires Both Domains of the F420:γ-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis.
Ghader Bashiri, Aisyah M Rehan, Sreevalsan Sreebhavan, Heather M Baker, Edward N Baker, Christopher J Squire

J Biol Chem· March 2016

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