Publications by authors named "Christopher Timperley"

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Editorial: Robotics software engineering.
Federico Ciccozzi, Ivano Malavolta, Christopher Timperley, Andreas Angerer, Alwin Hoffmann

Front Robot AI· October 2025

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Structure-activity studies of bispyridinium antinicotinics to select candidates to treat soman intoxication as part of a combined therapy.
Simon R Turner, Christopher M Timperley, Mike Bird, A Christopher Green, Matthew E Price

PLoS One· May 2025

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The synthesis and influence of the novel bispyridinium compound LB1 on the effectiveness of the standard antidotal treatment of organophosphorus nerve agent intoxicated mice and some structure-activity considerations.
Jiri Kassa, Rachael E Ambler, Lynda J Brown, Jaime Cummins, A Christopher Green, Christopher M Timperley

Chem Biol Interact· May 2025

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The use of bispyridinium non-oxime analogues for the restoration of nerve agent impaired neuromuscular transmission in rat hemidiaphragms - Structure optimization.
Niko Amend, Christopher M Timperley, Mike Bird, A Christopher Green, Franz Worek

Toxicol Lett· June 2024

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The risk associated with organophosphorus nerve agents: from their discovery to their unavoidable threat, current medical countermeasures and perspectives.
Camille Voros, José Dias, Christopher M Timperley, Florian Nachon, Richard C D Brown

Chem Biol Interact· May 2024

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Restoration of nerve agent impaired neuromuscular transmission in rat diaphragm by bispyridinium non-oximes - Structure-activity relationships.
Niko Amend, Christopher M Timperley, Mike Bird, A Christopher Green, Franz Worek

Toxicology· March 2024

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Biochemical and Structural Insights into FIH-Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains.
Benjamin G Saward, Thomas M Leissing, Ian J Clifton, Anthony Tumber, Christopher M Timperley

Chembiochem· February 2023

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Influence of Experimental End Point on the Therapeutic Efficacy of Essential and Additional Antidotes in Organophosphorus Nerve Agent-Intoxicated Mice.
Jiri Kassa, Christopher M Timperley, Mike Bird, A Christopher Green, John E H Tattersall

Toxics· April 2022

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Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 3. On medical care and treatment of injuries from sulfur mustard.
Christopher M Timperley, Jonathan E Forman, Mohammad Abdollahi, Abdullah Saeed Al-Amri, Augustin Baulig

Toxicology· November 2021

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Molecular determinants of binding of non-oxime bispyridinium nerve agent antidote compounds to the adult muscle nAChR.
Max Epstein, Karan Bali, Thomas J Piggot, A Christopher Green, Christopher M Timperley

Toxicol Lett· April 2021

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Influence of experimental end point on the therapeutic efficacy of the antinicotinic compounds MB408, MB442 and MB444 in treating nerve agent poisoned mice - a comparison with oxime-based treatment.
Jiri Kassa, Christopher M Timperley, Mike Bird, A Christopher Green, John E H Tattersall

Toxicol Mech Methods· November 2020

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3-Quinuclidinyl-α-methoxydiphenylacetate: A multi-targeted ligand with antimuscarinic and antinicotinic effects designed for the treatment of anticholinesterase poisoning.
Christopher M Timperley, Mike Bird, Samuel J Gore, Christopher D Lindsay, Helen Rice

Toxicol Lett· June 2020

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Assessment of false transmitters as treatments for nerve agent poisoning.
Charlotte Whitmore, Christopher D Lindsay, Mike Bird, Samuel J Gore, Helen Rice, Christopher M Timperley

Toxicol Lett· March 2020

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Synthesis and μ-Opioid Activity of the Primary Metabolites of Carfentanil.
Fu-Lian Hsu, Andrew J Walz, James M Myslinski, Li Kong, Michael G Feasel, Christopher M Timperley

ACS Med Chem Lett· November 2019

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Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 1. On medical care and treatment of injuries from nerve agents.
Christopher M Timperley, Jonathan E Forman, Mohammad Abdollahi, Abdullah Saeed Al-Amri, Augustin Baulig

Toxicology· March 2019

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Advice on assistance and protection from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 2. On preventing and treating health effects from acute, prolonged, and repeated nerve agent exposure, and the identification of medical countermeasures able to reduce or eliminate the longer term health effects of nerve agents.
Christopher M Timperley, Mohammad Abdollahi, Abdullah Saeed Al-Amri, Augustin Baulig, Djafer Benachour

Toxicology· February 2019

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Advice from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons on riot control agents in connection to the Chemical Weapons Convention.
Christopher M Timperley, Jonathan E Forman, Pal Åas, Mohammad Abdollahi, Djafer Benachour

RSC Adv· December 2018

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Open-Ended Evolution: Perspectives from the OEE Workshop in York.
Tim Taylor, Mark Bedau, Alastair Channon, David Ackley, Wolfgang Banzhaf, Christopher Timperley

Artif Life· October 2018

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Advice on chemical weapons sample stability and storage provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons to increase investigative capabilities worldwide.
Christopher M Timperley, Jonathan E Forman, Mohammad Abdollahi, Abdullah Saeed Al-Amri, Isel Pascual Alonso

Talanta· October 2018

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Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice.
Jiri Kassa, Christopher M Timperley, Mike Bird, Rebecca L Williams, A Christopher Green

Toxicology· September 2018

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Evaluation of the Influence of Three Newly Developed Bispyridinium Anti-nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice.
Jiri Kassa, Christopher M Timperley, Mike Bird, Rebecca L Williams, A Christopher Green

Basic Clin Pharmacol Toxicol· April 2018

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Evaluation of the benefit of the bispyridinium compound MB327 for the antidotal treatment of nerve agent-poisoned mice.
Jiri Kassa, Miroslav Pohanka, Christopher M Timperley, Mike Bird, A Christopher Green

Toxicol Mech Methods· June 2016

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Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines.
Avi Ring, Bjorn Oddvar Strom, Simon R Turner, Christopher M Timperley, Michael Bird

PLoS One· May 2016

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Pharmacokinetic profile and quantitation of protection against soman poisoning by the antinicotinic compound MB327 in the guinea-pig.
Matthew E Price, Cerys J Docx, Helen Rice, Sarah J Fairhall, Sarah J C Poole, Christopher M Timperley

Toxicol Lett· February 2016

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Potency of irritation by benzylidenemalononitriles in humans correlates with TRPA1 ion channel activation.
Christopher D Lindsay, Christopher Green, Mike Bird, James T A Jones, James R Riches, Christopher M Timperley

R Soc Open Sci· January 2015

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