Publications by authors named "Christopher Towler"

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Six Minutes of Physical Activity Improves Mood in Older Adults: A Pilot Study.
Ali Boolani, Shantanu Sur, Da Yang, Abby Avolio, Aurora Goodwin, Christopher Towler

J Geriatr Phys Ther· July 2021

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Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.
Matthew J LaMarche, Michael Acker, Andreea Argintaru, Daniel Bauer, Julie Boisclair, Christopher Towler

J Med Chem· November 2020

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Level-wise differences in lateral bending moment are associated with microstructural alterations in bovine caudal intervertebral discs.
Sarah E Duclos, Samantha K Denning, Christopher Towler, Arthur J Michalek

J Exp Biol· October 2020

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Correction to Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors.
Jeffrey T Bagdanoff, Zhouliang Chen, Michael Acker, Ying-Nan Chen, Homan Chan, Christopher Towler

J Med Chem· April 2019

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Correction to 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.
Patrick Sarver, Michael Acker, Jeffrey T Bagdanoff, Zhouliang Chen, Ying-Nan Chen, Christopher Towler

J Med Chem· April 2019

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Health Differences in Didactic Versus Clinical Stage Graduate Allied Health Students.
Ali Boolani, David Schelly, Jeri Reid, Christopher Towler, Matthew L Smith

J Allied Health· March 2019

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6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.
Patrick Sarver, Michael Acker, Jeffrey T Bagdanoff, Zhouliang Chen, Ying-Nan Chen, Christopher Towler

J Med Chem· February 2019

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Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors.
Jeffrey T Bagdanoff, Zhouliang Chen, Michael Acker, Ying-Nan Chen, Homan Chan, Christopher Towler

J Med Chem· February 2019

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Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA).
Atwood K Cheung, Brian Hurley, Ryan Kerrigan, Lei Shu, Donovan N Chin, Christopher Towler

J Med Chem· December 2018

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Increased lumbar spinal column laxity due to low-angle, low-load cyclic flexion may predispose to acute injury.
Nicole C Gale, Stacey L Zeigler, Christopher Towler, Sumona Mondal, Kathleen A Issen

JOR Spine· December 2018

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A Novel Selective Soluble Guanylate Cyclase Activator, MGV354, Lowers Intraocular Pressure in Preclinical Models, Following Topical Ocular Dosing.
Ganesh Prasanna, Luciana Ferrara, Christopher Adams, Takeru Ehara, Byron Li, Christopher Towler

Invest Ophthalmol Vis Sci· April 2018

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The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma.
Takeru Ehara, Christopher M Adams, Doug Bevan, Nan Ji, Erik L Meredith, Christopher S Towler

J Med Chem· March 2018

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Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.
Jorge Garcia Fortanet, Christine Hiu-Tung Chen, Ying-Nan P Chen, Zhouliang Chen, Zhan Deng, Christopher Towler

J Med Chem· September 2016

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The influence of aqueous content in small scale salt screening--improving hit rate for weakly basic, low solubility drugs.
Peter B Tarsa, Christopher S Towler, Grahame Woollam, Jörg Berghausen

Eur J Pharm Sci· September 2010

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An investigation into the influence of counterion on the properties of some amorphous organic salts.
Christopher S Towler, Tonglei Li, Håkan Wikström, David M Remick, Manuel V Sanchez-Felix

Mol Pharm· June 2009

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Impact of molecular speciation on crystal nucleation in polymorphic systems: the conundrum of gamma glycine and molecular 'self poisoning'.
Christopher S Towler, Roger J Davey, Robert W Lancaster, Christopher J Price

J Am Chem Soc· October 2004

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