Publications by authors named "Christopher am Ende"

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Second-Generation Catalyst System for Ag-Mediated Liebeskind-Srogl Coupling of Tetrazine Thioethers with Arylboronic Acids.
William D Lambert, Stephanie Tsang, Ashlyn S Hillman, Chuanqi Wang, Christopher W Am Ende

J Org Chem· October 2025

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Sulfur fluoride exchange with carbon pronucleophiles.
Joseph R Novicki, Matthew D Teeter, Neil J Baldwin, Christopher W Am Ende, Thomas R Puleo

Chem Sci· September 2025

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Mechanistic differences between linear spirocyclic dialkyldiazirine probes for photoaffinity labeling.
Jessica G K O'Brien, Louis P Conway, Paramesh K Ramaraj, Appaso M Jadhav, Jun Jin, Christopher W Am Ende

Chem Sci· August 2024

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Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.
Martin Pettersson, Douglas S Johnson, John M Humphrey, Christopher W Am Ende, Todd W Butler

J Med Chem· June 2024

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Discovery of a Potent Deubiquitinase (DUB) Small-Molecule Activity-Based Probe Enables Broad Spectrum DUB Activity Profiling in Living Cells.
Daniel Conole, Fangyuan Cao, Christopher W Am Ende, Liang Xue, Sheila Kantesaria

Angew Chem Int Ed Engl· November 2023

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Thiomethyltetrazines Are Reversible Covalent Cysteine Warheads Whose Dynamic Behavior can be "Switched Off" Bioorthogonal Chemistry Inside Live Cells.
Amanda M Tallon, Yingrong Xu, Graham M West, Christopher W Am Ende, Joseph M Fox

J Am Chem Soc· July 2023

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Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells.
Jordan M Mattheisen, Chris Limberakis, Roger B Ruggeri, Matthew S Dowling, Christopher W Am Ende

J Am Chem Soc· May 2023

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Sulfur(VI) fluorides as tools in biomolecular and medicinal chemistry.
Sabrina N Carneiro, Samuel R Khasnavis, Jisun Lee, Todd W Butler, Jaimeen D Majmudar, Christopher W Am Ende

Org Biomol Chem· February 2023

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Structural basis of the acyl-transfer mechanism of human GPAT1.
Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, Jeanne S Chang, Stephen Noell, Christopher W Am Ende

Nat Struct Mol Biol· January 2023

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[F]Difluorocarbene for positron emission tomography.
Jeroen B I Sap, Claudio F Meyer, Joseph Ford, Natan J W Straathof, Alexander B Dürr, Christopher W Am Ende

Nature· June 2022

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Catalytic Activation of Bioorthogonal Chemistry with Light (CABL) Enables Rapid, Spatiotemporally Controlled Labeling and No-Wash, Subcellular 3D-Patterning in Live Cells Using Long Wavelength Light.
Andrew Jemas, Yixin Xie, Jessica E Pigga, Jeffrey L Caplan, Christopher W Am Ende

J Am Chem Soc· February 2022

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A proteome-wide atlas of lysine-reactive chemistry.
Mikail E Abbasov, Madeline E Kavanagh, Taka-Aki Ichu, Michael R Lazear, Yongfeng Tao, Christopher W Am Ende

Nat Chem· November 2021

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Publisher Correction: A proteome-wide atlas of lysine-reactive chemistry.
Mikail E Abbasov, Madeline E Kavanagh, Taka-Aki Ichu, Michael R Lazear, Yongfeng Tao, Christopher W Am Ende

Nat Chem· November 2021

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Late-stage difluoromethylation: concepts, developments and perspective.
Jeroen B I Sap, Claudio F Meyer, Natan J W Straathof, Ndidi Iwumene, Christopher W Am Ende

Chem Soc Rev· July 2021

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Protocol for clickable photoaffinity labeling and quantitative chemical proteomics.
Wankyu Lee, Zhen Huang, Christopher W Am Ende, Uthpala Seneviratne

STAR Protoc· June 2021

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Fluorophosphonates on-Demand: A General and Simplified Approach toward Fluorophosphonate Synthesis.
Jason K Dutra, Timothy L Foley, Zhen Huang, Ethan L Fisher, Erik A Lachapelle, Christopher W Am Ende

Chembiochem· May 2021

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Bioorthogonal chemistry.
Samuel L Scinto, Didier A Bilodeau, Robert Hincapie, Wankyu Lee, Sean S Nguyen, Christopher W Am Ende

Nat Rev Methods Primers· April 2021

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Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE.
Uthpala Seneviratne, Zhen Huang, Christopher W Am Ende, Todd W Butler, Leah Cleary

Cell Chem Biol· February 2021

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Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum.
Ryan M Esquejo, Manuel Roqueta-Rivera, Wei Shao, Peter E Phelan, Uthpala Seneviratne, Christopher W Am Ende

Cell Chem Biol· February 2021

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Probing the Mechanism of Photoaffinity Labeling by Dialkyldiazirines through Bioorthogonal Capture of Diazoalkanes.
Jessica G K O'Brien, Andrew Jemas, Papa Nii Asare-Okai, Christopher W Am Ende, Joseph M Fox

Org Lett· December 2020

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Fluorophosphonate-Based Degrader Identifies Degradable Serine Hydrolases by Quantitative Proteomics.
S Denise Field, Wankyu Lee, Jason K Dutra, Finley Scott F Serneo, Jon Oyer, Christopher W Am Ende

Chembiochem· October 2020

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Divergent Synthesis of Monosubstituted and Unsymmetrical 3,6-Disubstituted Tetrazines from Carboxylic Ester Precursors.
Yixin Xie, Yinzhi Fang, Zhen Huang, Amanda M Tallon, Christopher W Am Ende

Angew Chem Int Ed Engl· September 2020

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SuFEx Activation with Ca(NTf): A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides.
Subham Mahapatra, Cristian P Woroch, Todd W Butler, Sabrina N Carneiro, Sabrina C Kwan, Christopher W Am Ende

Org Lett· June 2020

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Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery.
Jeroen B I Sap, Natan J W Straathof, Thomas Knauber, Claudio F Meyer, Maurice Médebielle, Christopher W Am Ende

J Am Chem Soc· May 2020

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Studies on the Stability and Stabilization of Cyclooctenes through Radical Inhibition and Silver (I) Metal Complexation.
Yinzhi Fang, Joshua C Judkins, Samantha J Boyd, Christopher W Am Ende, Katarina Rohlfing

Tetrahedron· August 2019

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