Publications by authors named "Christos Polymeropoulos"

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Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, placebo-controlled trial.
Naoise C Synnott, Christos M Polymeropoulos, Changfu Xiao, Gunther Birznieks, Mihael H Polymeropoulos

PLoS One· September 2025

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Efficacy and safety of an alpha 7-nicotinic acetylcholine receptor agonist, VQW-765, in subjects with performance anxiety: randomised, double-blind, placebo-controlled trial.
Yunsheng He, Christos M Polymeropoulos, Michael A Mohrman, Sunny O Truslow, Changfu Xiao, Mihael H Polymeropoulos

Br J Psychiatry· July 2025

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Potential ASO-based personalized treatment for Charcot-Marie-Tooth disease type 2S.
Sandra Smieszek, Bartlomiej Przychodzen, Christina Tyner, Caroline Johnson, Haimeng Bai, Christos M Polymeropoulos, Mihael H Polymeropoulos

Mol Ther Nucleic Acids· March 2025

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Motion Syros: tradipitant effective in the treatment of motion sickness; a multicenter, randomized, double-blind, placebo-controlled study.
Vasilios M Polymeropoulos, Leah Kiely, Margaret L Bushman, E Blake Sutherland, Abigail R Goldberg, Christos M Polymeropoulos, Mihael H Polymeropoulos

Front Neurol· March 2025

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The Efficacy of Tradipitant in Patients With Diabetic and Idiopathic Gastroparesis in a Phase 3 Randomized Placebo-Controlled Clinical Trial.
Jesse L Carlin, Christos Polymeropoulos, Michael Camilleri, Anthony Lembo, Michaela Fisher, Mihael H Polymeropoulos

Clin Gastroenterol Hepatol· December 2024

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Screening effects of HCN channel blockers on sleep/wake behavior in zebrafish.
Fusun Doldur-Balli, Sandra P Smieszek, Brendan T Keenan, Amber J Zimmerman, Olivia J Veatch, Christos M Polymeropoulos, Mihael H Polymeropoulos

Front Neurosci· March 2024

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Efficacy and Safety of Iloperidone in Bipolar Mania: A Double-Blind, Placebo-Controlled Study.
Rosarelis Torres, Emily L Czeisler, Sean R Chadwick, Stephen M Stahl, Sandra P Smieszek, Christos M Polymeropoulos, Mihael H Polymeropoulos

J Clin Psychiatry· January 2024

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Corrigendum: Case report: A patient with Delayed Sleep-Wake Phase Disorder and Optic Nerve Hypoplasia treated with tasimelteon: a case study.
Sandra P Smieszek, Alyssa R Kaden, Caroline E Johnson, Jennifer L Brzezynski, Changfu Xiao, Christos M Polymeropoulos, Mihael H Polymeropoulos

Front Neurosci· January 2024

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Case report: A patient with Delayed Sleep-Wake Phase Disorder and Optic Nerve Hypoplasia treated with tasimelteon: a case study.
Sandra P Smieszek, Alyssa R Kaden, Caroline E Johnson, Jennifer L Brzezynski, Changfu Xiao, Christos M Polymeropoulos, Mihael H Polymeropoulos

Front Neurosci· November 2023

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Enrichment of Patients With Ehlers Danlos Syndrome in Idiopathic Gastroparesis-A Gene Set Enrichment Analysis.
Sandra P Smieszek, Jesse L Carlin, Michaela A Fisher, Darby S Madonick, Caleigh Q Kupersmith, Christos M Polymeropoulos, Mihael H Polymeropoulos

Clin Transl Gastroenterol· March 2023

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Once-daily tasimelteon (VEC-162) for jet lag following transmeridian travel: A multicenter, randomized, double-blind, placebo-controlled trial.
Christos M Polymeropoulos, Vasilios M Polymeropoulos, Emily L Czeisler, Michaela A Fisher, Sandra P Smieszek, Mihael H Polymeropoulos

Front Neurol· September 2022

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Case report: A novel missense variant in melanopsin associates with delayed sleep phenotype: Whole genome sequencing study.
Sandra P Smieszek, Christos M Polymeropoulos, Gunther Birznieks, Mihael H Polymeropoulos

Front Genet· September 2022

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Elevated plasma levels of CXCL16 in severe COVID-19 patients.
Sandra P Smieszek, Vasilios M Polymeropoulos, Christos M Polymeropoulos, Bartlomiej P Przychodzen, Gunther Birznieks, Mihael H Polymeropoulos

Cytokine· April 2022

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Enrichment of Motilin Receptor Loss-of-Function Variants in Gastroparesis.
Sandra P Smieszek, Jesse L Carlin, Changfu Xiao, Gunther Birznieks, Christos M Polymeropoulos, Mihael H Polymeropoulos

Clin Transl Gastroenterol· April 2022

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Simulated driving performance in healthy adults after night-time administration of 20 mg tasimelteon.
Rosarelis Torres, Michaela Fisher, Gunther Birznieks, Christos Polymeropoulos, Gary G Kay, Mihael H Polymeropoulos

J Sleep Res· February 2022

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Corrigendum to "Assessing the potential correlation of polymorphisms in the IL6R with relative IL6 elevation in severely ill COVID-19 patients" [Cytokine 148 (2021) 155662].
Sandra P Smieszek, Bartlomiej P Przychodzen, Vasilios M Polymeropoulos, Bushra A Mina, Christos M Polymeropoulos, Mihael H Polymeropoulos

Cytokine· January 2022

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Genomic and phenotypic characterization of Investigator Global Assessment (IGA) scale-based endotypes in atopic dermatitis.
Sandra P Smieszek, Bartlomiej Przychodzen, Sarah E Welsh, Jennifer L Brzezynski, Alyssa R Kaden, Christos Polymeropoulos, Mihael H Polymeropoulos

J Am Acad Dermatol· December 2021

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Tasimelteon safely and effectively improves sleep in Smith-Magenis syndrome: a double-blind randomized trial followed by an open-label extension.
Christos M Polymeropoulos, Justin Brooks, Emily L Czeisler, Michaela A Fisher, Mary M Gibson, Mihael H Polymeropoulos

Genet Med· December 2021

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Assessing the potential correlation of polymorphisms in the IL6R with relative IL6 elevation in severely ill COVID-19 patients'.
Sandra P Smieszek, Bartlomiej P Przychodzen, Vasilios M Polymeropoulos, Christos M Polymeropoulos, Mihael H Polymeropoulos

Cytokine· December 2021

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An observational study investigating the CRY1Δ11 variant associated with delayed sleep-wake patterns and circadian metabolic output.
Sandra P Smieszek, Jennifer L Brzezynski, Alyssa R Kaden, Jordan A Shinn, Jingyuan Wang, Christos Polymeropoulos, Mihael H Polymeropoulos

Sci Rep· October 2021

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Loss-of-function mutations in IFNAR2 in COVID-19 severe infection susceptibility.
Sandra P Smieszek, Vasilios M Polymeropoulos, Changfu Xiao, Christos M Polymeropoulos, Mihael H Polymeropoulos

J Glob Antimicrob Resist· September 2021

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Tradipitant in the Treatment of Motion Sickness: A Randomized, Double-Blind, Placebo-Controlled Study.
Vasilios M Polymeropoulos, Mark É Czeisler, Mary M Gibson, Austin A Anderson, Jane Miglo, Christos M Polymeropoulos, Mihael H Polymeropoulos

Front Neurol· September 2020

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Efficacy of Tasimelteon (HETLIOZ®) in the Treatment of Jet Lag Disorder Evaluated in an 8-h Phase Advance Model; a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial.
Christos M Polymeropoulos, Michael A Mohrman, Madison S Keefe, Jennifer L Brzezynski, Jingyuan Wang, Vasilios M Polymeropoulos, Mihael H Polymeropoulos

Front Neurol· July 2020

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