Publications by authors named "Chuan Shih"

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Advancing precision therapy for colorectal cancer: Developing clinical indications for multi-target kinase inhibitor BPR1J481 using patient-derived xenograft models.
Ya-Chu Tang, Jing-Jim Ou, Shu-Ching Hsu, Chih-Hsiang Huang, Li-Mei Lin, Chuan Shih

Pharmacol Res· January 2025

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Discovery of a mu-opioid receptor modulator that in combination with morphinan antagonists induces analgesia.
Yi-Han Huang, Shu-Yu Lin, Li-Chin Ou, Wei-Cheng Huang, Po-Kuan Chao, Chuan Shih

Cell Chem Biol· November 2024

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DBPR116, a Prodrug of BPRMU191, in Combination with Naltrexone as a Safer Opioid Analgesic Than Morphine via Peripheral Administration.
Shu-Yu Lin, Yung-Chiao Chang, Ya-Wen Tien, Yu-Hsien Kuo, Hsiao-Fu Chang, Chuan Shih

J Med Chem· November 2024

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Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation.
Ramajayam Kuppusamy, Ying-Ting Hsu, Yi-Yu Ke, Po-Wei Chang, Yung-Chiao Chang, Chuan Shih

Eur J Med Chem· December 2022

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Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone.
Shu-Yu Lin, Ya-Wen Tien, Yi-Yu Ke, Yung-Chiao Chang, Hsiao-Fu Chang, Chuan Shih

Bioorg Chem· November 2022

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Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design.
Teng-Kuang Yeh, Jen-Shin Song, Po-Wei Chang, Jin-Chen Yu, Chia-Hwa Chang, Chuan Shih

Eur J Med Chem· February 2022

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Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model.
Kun-Hung Lee, Wan-Ching Yen, Wen-Hsing Lin, Pei-Chen Wang, You-Liang Lai, Chuan Shih

J Med Chem· October 2021

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Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins.
Ya-Hui Chi, Teng-Kuang Yeh, Yi-Yu Ke, Wen-Hsing Lin, Chia-Hua Tsai, Chuan Shih

J Med Chem· June 2021

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Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery.
Lun K Tsou, Shiu-Hwa Yeh, Shau-Hua Ueng, Chun-Ping Chang, Jen-Shin Song, Chuan Shih

Sci Rep· October 2020

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Correction to Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors.
Yi-Hui Peng, Fang-Yu Liao, Chen-Tso Tseng, Ramajayam Kuppusamy, An-Siou Li, Chuan Shih

J Med Chem· July 2020

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BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine.
Po-Kuan Chao, Hsiao-Fu Chang, Wan-Ting Chang, Teng-Kuang Yeh, Li-Chin Ou, Chuan Shih

Neuropharmacology· April 2020

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Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors.
Yi-Hui Peng, Fang-Yu Liao, Chen-Tso Tseng, Ramajayam Kuppusamy, An-Siou Li, Chuan Shih

J Med Chem· February 2020

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Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.
Wen-Hsing Lin, Su-Ying Wu, Teng-Kuang Yeh, Chiung-Tong Chen, Jen-Shin Song, Chuan Shih

J Med Chem· December 2019

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Linker Optimization and Therapeutic Evaluation of Phosphatidylserine-Targeting Zinc Dipicolylamine-based Drug Conjugates.
Yu-Wei Liu, Yun-Yu Chen, Chia-Yu Hsu, Tai-Yu Chiu, Kuan-Liang Liu, Chuan Shih

J Med Chem· July 2019

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The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2',4'-dimethyl-4,5'-bi-1,3-thiazol-2-amines and naloxone.
Shu-Yu Lin, Yu-Hsien Kuo, Ya-Wen Tien, Yi-Yu Ke, Wan-Ting Chang, Chuan Shih

Eur J Med Chem· April 2019

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Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition.
Yi-Yu Ke, Chun-Ping Chang, Wen-Hsing Lin, Chia-Hua Tsai, I-Chen Chiu, Chuan Shih

Eur J Med Chem· May 2018

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4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy.
Shu-Yu Lin, Teng-Kuang Yeh, Jen-Shin Song, Ming-Shiu Hung, Ming-Fu Cheng, Chuan Shih

Bioorg Chem· April 2018

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Design, Synthesis, and Evaluation of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors.
Teng-Kuang Yeh, Ching-Chuan Kuo, Yue-Zhi Lee, Yi-Yu Ke, Kuang-Feng Chu, Chuan Shih

J Med Chem· July 2017

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Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity.
Cheng-Wei Yang, Yue-Zhi Lee, Hsing-Yu Hsu, Chuan Shih, Yu-Sheng Chao

Sci Rep· June 2017

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1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine.
Po-Kuan Chao, Shau-Hua Ueng, Li-Chin Ou, Teng-Kuang Yeh, Wan-Ting Chang, Chuan Shih

Anesthesiology· May 2017

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Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists.
Sheng-Ren Chen, Yi-Yu Ke, Teng-Kuang Yeh, Shu-Yu Lin, Li-Chin Ou, Chuan Shih

Eur J Med Chem· January 2017

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Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation.
Yung Chang Hsu, Mohane Selvaraj Coumar, Wen-Chieh Wang, Hui-Yi Shiao, Yi-Yu Ke, Chuan Shih

Oncotarget· December 2016

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Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK).
Chih-Hsiang Tu, Wen-Hsing Lin, Yi-Hui Peng, Tsu Hsu, Jian-Sung Wu, Chuan Shih

J Med Chem· April 2016

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Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.
Yi-Hui Peng, Shau-Hua Ueng, Chen-Tso Tseng, Ming-Shiu Hung, Jen-Shin Song, Chuan Shih

J Med Chem· January 2016

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Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy.
Shu-Yu Lin, Teng-Kuang Yeh, Ching-Chuan Kuo, Jen-Shin Song, Ming-Fu Cheng, Chuan Shih

J Med Chem· January 2016

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