Publications by authors named "Chun-Yan Lim"

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Architecture of the human KICSTOR and GATOR1-KICSTOR complexes.
Fei Teng, Huan Zeng, Xinyi Mai, Shujun Chen, Lulu Wang, Chun-Yan Lim

Nat Struct Mol Biol· December 2025

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Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
Hijai R Shin, Y Rose Citron, Lei Wang, Laura Tribouillard, Claire S Goul, Chun-Yan Lim

Science· September 2022

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Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts.
Man Mohan Shrestha, Chun-Yan Lim, Xuezhi Bi, Robert C Robinson, Weiping Han

Front Endocrinol (Lausanne)· December 2021

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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Oliver B Davis, Hijai R Shin, Chun-Yan Lim, Emma Y Wu, Matthew Kukurugya

Dev Cell· February 2021

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Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
Rosalie E Lawrence, Simon A Fromm, Yangxue Fu, Adam L Yokom, Do Jin Kim, Chun-Yan Lim

Science· November 2019

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ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C.
Chun-Yan Lim, Oliver B Davis, Hijai R Shin, Justin Zhang, Charles A Berdan

Nat Cell Biol· October 2019

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A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.
Vito W Rebecca, Michael C Nicastri, Noel McLaughlin, Colin Fennelly, Quentin McAfee, Chun-Yan Lim

Cancer Discov· November 2017

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The lysosome as a command-and-control center for cellular metabolism.
Chun-Yan Lim, Roberto Zoncu

J Cell Biol· September 2016

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Tropomodulin3 as the link between insulin-activated AKT2 and cortical actin remodeling in preparation of GLUT4 exocytosis.
Chun-Yan Lim, Weiping Han

Bioarchitecture· February 2016

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Adiponectin is released via a unique regulated exocytosis pathway from a pre-formed vesicle pool on insulin stimulation.
Chun-Yan Lim, Wanjin Hong, Weiping Han

Biochem J· November 2015

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Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation.
Jong In Kim, Jin Young Huh, Jee Hyung Sohn, Sung Sik Choe, Yun Sok Lee, Chun Yan Lim

Mol Cell Biol· May 2015

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Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling.
Chun-Yan Lim, Xuezhi Bi, Donghai Wu, Jae Bum Kim, Peter W Gunning

Nat Commun· January 2015

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Arp2/3 complex regulates adipogenesis by controlling cortical actin remodelling.
Wulin Yang, Shermaine Thein, Chun-Yan Lim, Russell E Ericksen, Shigeki Sugii

Biochem J· December 2014

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Insulin-stimulated leptin secretion requires calcium and PI3K/Akt activation.
Yue Wang, Yusuf Ali, Chun-Yan Lim, Wanjin Hong, Zhiping P Pang

Biochem J· March 2014

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Neonatal overnutrition in mice exacerbates high-fat diet-induced metabolic perturbations.
Zhiguo Liu, Chun Yan Lim, Michelle Yu-Fah Su, Stephanie Li Ying Soh, Guanghou Shui

J Endocrinol· November 2013

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Glucose intolerance and impaired insulin secretion in pancreas-specific signal transducer and activator of transcription-3 knockout mice are associated with microvascular alterations in the pancreas.
Elena Kostromina, Natalia Gustavsson, Xiaorui Wang, Chun-Yan Lim, George K Radda

Endocrinology· May 2010

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FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1.
Guoqing Yang, Chun-Yan Lim, Chao Li, Xiaoqiu Xiao, George K Radda

J Biol Chem· February 2009

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