Publications by authors named "Chunyong Ding"

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Discovery of 2-tetrahydroisoquinoline substituted quinazoline derivatives as lysine methyltransferase G9a inhibitors with in vivo antitumor efficacy.
Mengjie Shao, Lixin Gao, Jiahui Xu, Lingfeng Zhu, Yiting Lu, Chunyong Ding

Eur J Med Chem· December 2025

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Panobinostat suppresses cGAS-STING pathway activation and ameliorates DSS-induced colitis in mice.
Meizhen Qin, Zijiao Liu, Meng Wang, Wanqing Yang, Zihua Zhou, Chunyong Ding

Int Immunopharmacol· December 2025

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Design, synthesis, and biological evaluation of long-acting glucagon-like peptide-1 (GLP-1) conjugates modified with dual fatty acids and a proline-alanine-serine (PAS) polypeptide.
Chengcheng Wang, Jinhua Zhang, Yuanzhen Dong, Jun Xu, Jianguang Lu, Chunyong Ding

Bioorg Med Chem· October 2025

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A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers.
Juanjuan Feng, Xuanzheng Xiao, Xinting Xia, Jian Min, Weiying Tang, Chunyong Ding

Cancer Cell· October 2025

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Microglial STING activation promotes neuroinflammation and pathological changes in experimental mice with intracerebral haemorrhage.
Yu-Xiao Xue, Yi-Jun Chen, Mei-Zhen Qin, Fan-Fan Shang, Yi-Ting Lu, Chun-Yong Ding

Acta Pharmacol Sin· September 2025

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Next-Generation HER-2 Tumor-Targeted Delivery of the STING Agonist Immune-Stimulating Antibody Conjugate (ISAC) Improves Anticancer Efficacy and Induces Immunological Memory.
Gang Wu, Chuanfei Yu, Chunyong Ding, Shengtao Yao, Jialiang Du

MedComm (2020)· July 2025

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Design, Synthesis, and Biological Evaluation of a Novel Long-Acting Human Complement C3 Inhibitor Synthesized via the PASylation-Lipidation Modular (PLM) Platform.
Chengcheng Wang, Yapeng Wang, Yu Duan, Yuanzhen Dong, Haoju Hua, Chunyong Ding

Bioconjug Chem· June 2025

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Identification of a Novel Small Molecule STING Agonist Reshaping the Immunomicroenvironment of Pancreatic Ductal Adenocarcinoma.
Pengyi Liu, Minmin Shi, Yang Liu, Yihao Liu, Jiayu Lin, Chunyong Ding

Int J Biol Sci· June 2025

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Discovery of Hydrazineyl Amide Derivative of Pseudolaric Acid B for Reprogramming Tumor-Associated Macrophages Against Tumor Growth.
Xia Peng, Siqi Yu, Lin Xu, Qinghua Wang, Lin Yang, Chunyong Ding

Molecules· May 2025

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Rational Design of Site-Specific Fatty Acid Derivatives to Extend the Half-Life of Fibroblast Growth Factor 21.
Chengcheng Wang, Yapeng Wang, Yuanzhen Dong, Yu Duan, Ying Zhang, Chunyong Ding

Bioconjug Chem· April 2025

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A derivative of tanshinone IIA and salviadione, 15a, inhibits inflammation and alleviates DSS-induced colitis in mice by direct binding and inhibition of RIPK2.
Cheng-Hong Hu, Yue Chen, Tian-Yang Jin, Zhe Wang, Bo Jin, Chun-Yong Ding

Acta Pharmacol Sin· March 2025

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Synthesis and pharmacological evaluation of natural product diphyllin derivatives against head and neck squamous cell carcinoma.
Yuqi Tang, Xinhua Pan, Fan-Fan Shang, Yang Li, Chaojun Zhang, Chunyong Ding

Eur J Med Chem· March 2025

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Design, Synthesis, and Pharmacological Evaluation of Quinazoline and Quinoline Derivatives as Potent ENPP1 Inhibitors for Cancer Immunotherapy.
Jie He, Xiaoyu Ma, Jia Sun, Manman Chen, Lan Xu, Chunyong Ding

J Med Chem· March 2025

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Correction to "Structural Modification and Pharmacological Evaluation of (Thiadiazol-2-yl)pyrazines as Novel Piezo1 Agonists for the Intervention of Disuse Osteoporosis".
Hairong Tang, Ruihan Hao, Ding Ma, Yujia Yao, Chunyong Ding

J Med Chem· December 2024

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Structural Modification and Pharmacological Evaluation of (Thiadiazol-2-yl)pyrazines as Novel Piezo1 Agonists for the Intervention of Disuse Osteoporosis.
Hairong Tang, Ruihan Hao, Ding Ma, Yujia Yao, Chunyong Ding

J Med Chem· November 2024

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A Novel Piezo1 Agonist Promoting Mesenchymal Stem Cell Proliferation and Osteogenesis to Attenuate Disuse Osteoporosis.
Ruihan Hao, Hairong Tang, Chunyong Ding, Bhavana Rajbanshi, Yuhang Liu, Ding Ma

Small Sci· September 2024

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Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells.
Yang Li, Yuyuan Zhu, Fan-Fan Shang, Lin Xu, Defang Jiang, Chunyong Ding

J Med Chem· May 2024

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Design, Synthesis, and Pharmacological Evaluation of Spiro[carbazole-3,3'-pyrrolidine] Derivatives as cGAS Inhibitors for Treatment of Acute Lung Injury.
Mingjie Chen, Shuyue Lei, Zihua Zhou, Meng Wang, Chunlan Feng, Chunyong Ding

J Med Chem· April 2024

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Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD).
Ruoqing Zeng, Meimiao Fang, Ancheng Shen, Xiaolei Chai, Yumiao Zhao, Chunyong Ding

J Med Chem· March 2024

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Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors.
Chenghu Xie, Bo Liu, Zilan Song, Ye Yang, Mengdi Dai, Chunyong Ding

J Med Chem· December 2023

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Design, Synthesis, and Pharmacological Evaluation of Multisubstituted Pyrido[4,3-]pyrimidine Analogues Bearing Deuterated Methylene Linkers as Potent KRAS Inhibitors.
Xuanzheng Xiao, Juanjuan Feng, Jing Ma, Xinting Xia, Xiaogu Liu, Chunyong Ding

J Med Chem· November 2023

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Discovery of Triazolyl Derivatives of Cucurbitacin B Targeting IGF2BP1 against Non-Small Cell Lung Cancer.
Fan-Fan Shang, Qing Lu, Tailiang Lin, Miaoxia Pu, Ruoxuan Xiao, Chunyong Ding

J Med Chem· September 2023

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Photochemically controlled activation of STING by CAIX-targeting photocaged agonists to suppress tumor cell growth.
Chunyong Ding, Mengyan Du, Zhi Xiong, Xue Wang, Hongji Li

Chem Sci· June 2023

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Discovery of 2-Indazole-3-carboxamide Derivatives as Novel Potent Prostanoid EP4 Receptor Antagonists for Colorectal Cancer Immunotherapy.
Zhiyuan Cheng, Yijie Wang, Yao Zhang, Chan Zhang, Mengru Wang, Chunyong Ding

J Med Chem· May 2023

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CYD0281, a Bcl-2 BH4 domain antagonist, inhibits tumor angiogenesis and breast cancer tumor growth.
Yihua Lin, Yiling Zhao, Minggui Chen, Zishuo Li, Qiao Liu, Yi Ding, Chunyong Ding, Ye Ding

BMC Cancer· May 2023

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