Publications by authors named "Cindy Marando"

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Phase 1/2 Study of the Pan-PIM Kinase Inhibitor INCB053914 Alone or in Combination With Standard-of-Care Agents in Patients With Advanced Hematologic Malignancies.
Manish R Patel, William Donnellan, Michael Byrne, Adam S Asch, Amer M Zeidan, Cindy Marando

Clin Lymphoma Myeloma Leuk· September 2023

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Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11β-HSD1 using a scaffold-hopping approach.
Colin Zhang, Meizhong Xu, Chunhong He, Jincong Zhuo, David M Burns, Cindy Marando

Bioorg Med Chem Lett· August 2022

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Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor.
Holly K Koblish, Liangxing Wu, Liang-Chuan S Wang, Phillip C C Liu, Richard Wynn, Cindy Marando

Cancer Discov· June 2022

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Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies.
Holly Koblish, Yun-Long Li, Niu Shin, Leslie Hall, Qian Wang, Cindy Marando

PLoS One· December 2018

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A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3.
Xiangdong Liu, Qian Wang, Gengjie Yang, Cindy Marando, Holly K Koblish

Clin Cancer Res· November 2011

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Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition.
David M Burns, Yun-Long Li, Eric Shi, Chunhong He, Meizhong Xu, Cindy A Marando

Bioorg Med Chem Lett· July 2009

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Design and identification of selective HER-2 sheddase inhibitors via P1' manipulation and unconventional P2' perturbations to induce a molecular metamorphosis.
Wenqing Yao, Jincong Zhuo, David M Burns, Yun-Long Li, Ding-Quan Qian, Cindy A Marando

Bioorg Med Chem Lett· January 2008

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Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations.
David M Burns, Chunhong He, Yanlong Li, Peggy Scherle, Xiangdong Liu, Cindy A Marando

Bioorg Med Chem Lett· January 2008

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Analysis of Epstein-Barr virus reservoirs in paired blood and breast cancer primary biopsy specimens by real time PCR.
R Serene Perkins, Katherine Sahm, Cindy Marando, Diana Dickson-Witmer, Gregory R Pahnke

Breast Cancer Res· February 2007

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Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
Wenqing Yao, Jincong Zhuo, David M Burns, Meizhong Xu, Colin Zhang, Cindy A Marando

J Med Chem· February 2007

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Selective inhibition of ADAM metalloproteases blocks HER-2 extracellular domain (ECD) cleavage and potentiates the anti-tumor effects of trastuzumab.
Xiangdong Liu, Jordan S Fridman, Qian Wang, Eian Caulder, Gengjie Yang, Cindy Marando

Cancer Biol Ther· June 2006

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Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells.
Phillip C C Liu, Xiangdong Liu, Yanlong Li, Maryanne Covington, Richard Wynn, Cindy Marando

Cancer Biol Ther· June 2006

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Liver transplantation as definitive treatment for a factor V Leiden mutation.
Stephen P Dunn, Anthony Tsai, Gregory Griffin, Stephen Toth, Adela T Casas-Melley, Cindy A Marando

J Pediatr· March 2005

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