Publications by authors named "Clinton Willis"

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Insights derived from testing a library of per- and polyfluoroalkyl substances (PFAS) in a battery of new approach methods (NAMs).
Grace Patlewicz, Richard Judson, Katie Paul Friedman, Barbara A Wetmore, Michael J DeVito, Clinton M Willis

J Toxicol Environ Health B Crit Rev· December 2025

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Assessing the impact of in vitro xenobiotic metabolism on estrogenic chemical bioactivity in high-throughput profiling assays.
Amanda Jurgelewicz, Kristen Breaux, Clinton M Willis, Felix R Harris, Gabrielle Byrd

Toxicology· November 2025

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A combination of high-throughput in vitro and in silico new approach methods for ecotoxicology hazard assessment for fish.
Jo Nyffeler, Felix R Harris, Clinton Willis, Gabrielle Byrd, Brett Blackwell

Environ Toxicol Chem· September 2025

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Assessing the effects of silver nanoparticles on ARPE-19 cells via high-throughput phenotypic profiling with the Cell Painting assay.
Gabrielle Byrd, Alice Goldstein-Plesser, Jo Nyffeler, Clinton M Willis, Anna Fisher

Toxicol Appl Pharmacol· September 2025

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Incorporating Metabolic Competence into High-Throughput Profiling Assays.
Amanda Jurgelewicz, Kristen Breaux, Clinton M Willis, Felix R Harris, Gabrielle Byrd

Toxicol Sci· August 2025

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TempO-seq and RNA-seq gene expression levels are highly correlated for most genes: A comparison using 39 human cell lines.
Laura J Word, Clinton M Willis, Richard S Judson, Logan J Everett, Sarah E Davidson-Fritz

PLoS One· May 2025

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Signature analysis of high-throughput transcriptomics screening data for mechanistic inference and chemical grouping.
Joshua A Harrill, Logan J Everett, Derik E Haggard, Laura J Word, Joseph L Bundy, Clinton Willis

Toxicol Sci· November 2024

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High-Throughput Transcriptomics Screen of ToxCast Chemicals in U-2 OS Cells.
Joseph L Bundy, Logan J Everett, Jesse D Rogers, Jo Nyffeler, Gabrielle Byrd, Clinton Willis

Toxicol Appl Pharmacol· October 2024

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Exploring the effects of experimental parameters and data modeling approaches on in vitro transcriptomic point-of-departure estimates.
Joshua A Harrill, Logan J Everett, Derik E Haggard, Joseph L Bundy, Clinton M Willis

Toxicology· January 2024

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Application of Cell Painting for chemical hazard evaluation in support of screening-level chemical assessments.
Jo Nyffeler, Clinton Willis, Felix R Harris, M J Foster, Bryant Chambers

Toxicol Appl Pharmacol· June 2023

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Combining phenotypic profiling and targeted RNA-Seq reveals linkages between transcriptional perturbations and chemical effects on cell morphology: Retinoic acid as an example.
Johanna Nyffeler, Clinton Willis, Felix R Harris, Laura W Taylor, Richard Judson

Toxicol Appl Pharmacol· June 2022

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Optimization of Human Neural Progenitor Cells for an Imaging-Based High-Throughput Phenotypic Profiling Assay for Developmental Neurotoxicity Screening.
Megan Culbreth, Johanna Nyffeler, Clinton Willis, Joshua A Harrill

Front Toxicol· February 2022

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High-Throughput Transcriptomics Platform for Screening Environmental Chemicals.
Joshua A Harrill, Logan J Everett, Derik E Haggard, Thomas Sheffield, Joseph L Bundy, Clinton M Willis

Toxicol Sci· April 2021

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Comparison of Approaches for Determining Bioactivity Hits from High-Dimensional Profiling Data.
Johanna Nyffeler, Derik E Haggard, Clinton Willis, R Woodrow Setzer, Richard Judson

SLAS Discov· February 2021

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Phenotypic Profiling of Reference Chemicals across Biologically Diverse Cell Types Using the Cell Painting Assay.
Clinton Willis, Johanna Nyffeler, Joshua Harrill

SLAS Discov· August 2020

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Bioactivity screening of environmental chemicals using imaging-based high-throughput phenotypic profiling.
Johanna Nyffeler, Clinton Willis, Ryan Lougee, Ann Richard, Katie Paul-Friedman

Toxicol Appl Pharmacol· January 2020

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