Publications by authors named "Clive Bate"

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GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice.
Berta Puig, Hermann C Altmeppen, Luise Linsenmeier, Karima Chakroun, Florian Wegwitz, Clive Bate

PLoS Pathog· January 2019

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The phospholipase A pathway controls a synaptic cholesterol ester cycle and synapse damage.
Craig Osborne, Ewan West, Clive Bate

J Cell Sci· April 2018

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Cholesterol ester hydrolase inhibitors reduce the production of synaptotoxic amyloid-β oligomers.
Harriet McHale-Owen, Clive Bate

Biochim Biophys Acta Mol Basis Dis· March 2018

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Monomeric amyloid-β reduced amyloid-β oligomer-induced synapse damage in neuronal cultures.
Clive Bate, Alun Williams

Neurobiol Dis· March 2018

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Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-β oligomers released from 7PA2 cells.
Robin S B Williams, Clive Bate

Neuropharmacology· January 2018

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Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-β.
Clive Bate

J Exp Neurosci· December 2017

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The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-β.
Ewan West, Craig Osborne, Clive Bate

J Cell Sci· September 2017

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Can we switch production of toxic Aβ oligomers to neuroprotective Aβ monomers to allow synapse regeneration?
Clive Bate

Neural Regen Res· September 2017

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Sialylated glycosylphosphatidylinositols suppress the production of toxic amyloid-β oligomers.
William Nolan, Harriet McHale-Owen, Clive Bate

Biochem J· August 2017

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Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses.
Clive Bate, William Nolan, Harriet McHale-Owen, Alun Williams

J Biol Chem· August 2016

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Glycosylphosphatidylinositols: More than just an anchor?
Clive Bate, William Nolan, Alun Williams

Commun Integr Biol· May 2016

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Does the tail wag the dog? How the structure of a glycosylphosphatidylinositol anchor affects prion formation.
Clive Bate, William Nolan, Alun Williams

Prion· March 2016

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An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA2 dependent signalling.
Robin S B Williams, Clive Bate

Neuropharmacology· February 2016

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Glimepiride protects neurons against amyloid-β-induced synapse damage.
Craig Osborne, Ewan West, William Nolan, Harriet McHale-Owen, Alun Williams, Clive Bate

Neuropharmacology· February 2016

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Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation.
Clive Bate, William Nolan, Alun Williams

J Biol Chem· January 2016

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cAMP-Inhibits Cytoplasmic Phospholipase A₂ and Protects Neurons against Amyloid-β-Induced Synapse Damage.
Clive Bate, Alun Williams

Biology (Basel)· September 2015

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Monoacylated Cellular Prion Proteins Reduce Amyloid-β-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage.
Ewan West, Craig Osborne, William Nolan, Clive Bate

Biology (Basel)· June 2015

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Enhanced neuronal degradation of amyloid-β oligomers allows synapse regeneration.
Clive Bate

Neural Regen Res· May 2015

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α-Synuclein-induced synapse damage in cultured neurons is mediated by cholesterol-sensitive activation of cytoplasmic phospholipase A2.
Clive Bate, Alun Williams

Biomolecules· March 2015

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Platelet-activating factor antagonists enhance intracellular degradation of amyloid-β42 in neurons via regulation of cholesterol ester hydrolases.
Charlotte Simmons, Victoria Ingham, Alun Williams, Clive Bate

Alzheimers Res Ther· August 2014

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Glimepiride reduces CD14 expression and cytokine secretion from macrophages.
Victoria Ingham, Alun Williams, Clive Bate

J Neuroinflammation· June 2014

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Clustering of sialylated glycosylphosphatidylinositol anchors mediates PrP-induced activation of cytoplasmic phospholipase A 2 and synapse damage.
Clive Bate, Alun Williams

Prion· February 2013

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The N-methylated peptide SEN304 powerfully inhibits Aβ(1-42) toxicity by perturbing oligomer formation.
Hozefa Amijee, Clive Bate, Alun Williams, Jasmeet Virdee, Ross Jeggo

Biochemistry· October 2012

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Neurodegeneration induced by clustering of sialylated glycosylphosphatidylinositols of prion proteins.
Clive Bate, Alun Williams

J Biol Chem· March 2012

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Ethanol protects cultured neurons against amyloid-β and α-synuclein-induced synapse damage.
Clive Bate, Alun Williams

Neuropharmacology· December 2011

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