Publications by authors named "Clive McCarthy"

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ETD001: A novel inhaled ENaC blocker with an extended duration of action in vivo.
Henry Danahay, Clive McCarthy, Thomas Schofield, Roy Fox, Holly Charlton

J Cyst Fibros· January 2025

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Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.
Robin A Fairhurst, Pascal Furet, Patricia Imbach-Weese, Frédéric Stauffer, Heinrich Rueeger, Clive McCarthy

J Med Chem· June 2022

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TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis.
Henry L Danahay, Sarah Lilley, Roy Fox, Holly Charlton, Juan Sabater, Clive McCarthy

Am J Respir Crit Care Med· April 2020

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Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
Robin A Fairhurst, Thomas H Marsilje, Stefan Stutz, Andreas Boos, Michel Niklaus, Clive McCarthy

Bioorg Med Chem Lett· April 2016

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Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).
Neil J Press, Roger J Taylor, Joseph D Fullerton, Pamela Tranter, Clive McCarthy

J Med Chem· September 2015

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The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist.
Nicola Arnold, David Beattie, Michelle Bradley, Andrew Brearley, Lyndon Brown, Clive McCarthy

Bioorg Med Chem Lett· September 2014

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Tropomyosin receptor kinase inhibitors: a patent update 2009 - 2013.
Clive McCarthy, Edward Walker

Expert Opin Ther Pat· July 2014

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Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway.
Ian Bruce, Mohammed Akhlaq, Graham C Bloomfield, Emma Budd, Brian Cox, Clive McCarthy

Bioorg Med Chem Lett· September 2012

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Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.
Neil J Press, Roger J Taylor, Joseph D Fullerton, Pamela Tranter, Clive McCarthy

J Med Chem· September 2012

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Design and synthesis of a library of chemokine antagonists.
Gurdip Bhalay, Birgit Albrecht, Mohammed Akhlaq, Urs Baettig, David Beer, Clive McCarthy

Bioorg Med Chem Lett· November 2011

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A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients.
Ralph Tiedt, Elisa Degenkolbe, Pascal Furet, Brent A Appleton, Sabrina Wagner, Clive McCarthy

Cancer Res· August 2011

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Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors.
Heinrich Rueeger, Jean-Michel Rondeau, Clive McCarthy, Henrik Möbitz, Marina Tintelnot-Blomley

Bioorg Med Chem Lett· April 2011

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A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of beta2-adrenoceptor agonists as inhaled long-acting bronchodilators.
David Beattie, Michelle Bradley, Andrew Brearley, Steven J Charlton, Bernard M Cuenoud, Clive McCarthy

Bioorg Med Chem Lett· September 2010

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Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors.
Carole Pissot-Soldermann, Marc Gerspacher, Pascal Furet, Christoph Gaul, Philipp Holzer, Clive McCarthy

Bioorg Med Chem Lett· April 2010

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Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.
Andreas Lerchner, Rainer Machauer, Claudia Betschart, Siem Veenstra, Heinrich Rueeger, Clive McCarthy

Bioorg Med Chem Lett· January 2010

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An efficient synthesis of nitroalkenes by alkene cross metathesis: facile access to small ring systems.
Graham P Marsh, Philip J Parsons, Clive McCarthy, Xavier G Corniquet

Org Lett· July 2007

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A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential.
Neil J Press, Roger J Taylor, Joseph D Fullerton, Pamela Tranter, Clive McCarthy

Bioorg Med Chem Lett· June 2005

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Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase.
Julian Levell, Peter Astles, Paul Eastwood, Jennifer Cairns, Olivier Houille, Clive McCarthy

Bioorg Med Chem· April 2005

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Mapping the kinase domain of Janus Kinase 3.
Christopher Adams, David J Aldous, Shelley Amendola, Paul Bamborough, Colin Bright, Clive McCarthy

Bioorg Med Chem Lett· September 2003

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Potent small molecule inhibitors of spleen tyrosine kinase (Syk).
Justine Y Q Lai, Paul J Cox, Rajesh Patel, Shazia Sadiq, David J Aldous, Clive McCarthy

Bioorg Med Chem Lett· September 2003

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Adenosine receptor ligands as potential therapeutics in asthma.
John R Fozard, Clive McCarthy

Curr Opin Investig Drugs· January 2002

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